Inflammatory skin diseases such as psoriasis and atopic dermatitis can severely impact both the physical and social aspect of a patient’s life. Aberrant inflammatory responses are thought to be a major causative factor in these disorders, but an abundance of different factors contribute to the development…

Promotores: Prof.dr.G.R. de Snoo and Dr. R. Heijungs

The soil-dwelling, filamentous bacteria of the genus Streptomyces are renowned for their production of useful secondary metabolites including antibiotics. The work described in this thesis provides new insights on the role and regulation of antibiotic production and resistance in these bacteria.

Streptomyces are bacteria abundant in soil that participate in diverse and complex interactions. These bacteria are the main producers of the antibiotics we currently use in the clinic.

Plastics have become an integral part of modern society due to their versatility and durability.

Elk onderdeel van de kringloop op een melkveebedrijf heeft een specifieke bacterie- en schimmelsamenstelling. Dat ontdekten de Leidse postdoc onderzoeker Sofia Gomes en haar begeleiders Nadia Soudzilovskaia en Peter van Bodegom in samenwerking met het Louis Bolk instituut en Naturalis Biodiversity Centre.…

This thesis aimed to investigate the impact of exposure dynamics, relative contributions of ENPs(particle) and ENPs(ion), and dosing regimens on the toxicity of ENPs varying in different physico-chemical properties, on the composition and functioning of soil microbial communities.

Gisteren verscheen er een artikel in Biznews over het watertekort in California. David Zetland, universitair docent aan het Leiden University College The Hague, gaf zijn mening over dit probleem.

Heterogeneous catalyzed processes are highly significant to the chemical industry. Dissociative chemisorption (DC) of molecules on surfaces is always considered as a step with a high degree of rate control for heterogeneous catalysis.

Promotor: Prof.dr. G.P. van Wezel

Vooral neerslag en bodemzuurgraad bepalen welke microben in een bepaalde habitat overleven en welke niet. Deze kennis is van belang om de biodiversiteit in stand te houden. Leidse milieukundigen werkten mee aan het onderzoek. Publicatie in Nature op 1 augustus.

Hybrid zones occur where two species meet and produce offspring (hybrids). Typically, hybrids show a considerable reduction in fitness. In this thesis two hybrid zones are treated.

Studievoorlichting

Image segmentation is a fundamental task in computer vision, with applications ranging from medical diagnostics to archaeological research.

This thesis focuses on enhancing predictions of central nervous system drug exposure using the LeiCNS-PK3.0, a physiologically based pharmacokinetic model.

There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.

Promotie

The book ‘Bestrijdingsmiddelen en Milieu' gives a transparent overview of facts and figures concerning pesticide use in the Netherlands and the impact of pesticides on the environment.

Antibiotic-resistant bacteria pose a major health threat. Addressing this challenge requires among others the development of new antibacterial compounds. The research described in this thesis focuses on discovering novel antibiotics from soil bacteria, specifically Streptomyces and Paenibacillus.Despite…

A management strategy has been developed for field margins to reduce pesticide drift to non-target areas and to promote biodiversity on arable land. To this end, 3 and 6 m wide strips along the edges of winter wheat, sugar beet and potato crops have been left unsprayed with herbicides and insecticides…

Promotor: G.P. van Wezel, Co-Promotor: E. Vijgenboom

Mycoheterotrophy is a particular mode of life in which plants obtain carbohydrates from their associated fungal partners, instead of by using photosynthesis.

The increasing resistance of pathogenic bacteria to antibiotics necessitates the discovery of new medicines.

The overall objectives of my thesis are to investigate the dynamics of the sorghum root microbiome and to explore the beneficial effects of the root microbiome on sorghum growth and stress tolerance.

My PhD thesis investigates the ecological significance of resistance against drought-induced air bubble formation inside the water conduits of plants (embolism), and the plasticity and functional aspects of stem anatomical traits in woody and herbaceous species.

Plants are colonized by an astounding number of microorganisms that can provide different life-support functions, including nutrient acquisition and protection against (a)biotic stresses like drought or pathogen attack.

The filamentous bacteria Streptomyces are widespread inhabitants of terrestrial soils.

Promotor: G.P. van Wezel, Co-promotor: D. Claessen

Supervisor: P.J.J. Hooykaas

Supervisor: P.J.J. Hooykaas Co-Supervisor: R. Offringa

Promotores: H.A. Udo de Haes, H.H.T. Prins, Co-promotor: H.H. de Iongh

A Josephson junction is a device where a thin insulating barrier or a nanostructure is placed between two superconducting leads. Such a junction is essential to superconducting qubits that store quantum information due to its anharmonic spectrum.

M. Danhof, Co-promotores: J. Freijer, A. Yassen

This thesis focuses on developing wafer-scale two-dimensional (2D) materials by combining synthesis, transfer, characterization, and device integration of graphene, hexagonal boron nitride (h-BN), and BN-doped amorphous carbon.

Co-creatie en multidisciplinair leren over grenzen heen.

Catalysis is of extreme relevance in the production of everyday materials and plays a central role in many aspects of our life.

The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.