Stars like the sun are born in large molecular clouds existing from gas and dust. During the formation process, the chemical composition of the material can be altered drastically by the changing physical conditions.

The research aims to explore the evolutionary adaptability of enzymes and the impact of temperature on protein evolution pathways, using M. tuberculosis β-lactamase BlaC as the object of study. Enzymes inherently embody a delicate balance between activity and stability, and the acquisition of new enzymatic…

New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.

Hydrogen fuel cells are expected to be pivotal in the energetic transition towards renewable energy sources such as solar and wind power. However, their industrial scalability is severely hindered by the high cost and degradation rate of platinum catalysts, one of their key components. Addressing this…

This thesis presents pioneering work on the panchromatic emission of some of the most luminous galaxies in the early Universe: star forming galaxies and active galactic nuclei.

Promotor: Prof.dr. P.G.L. Klinkhamer, Co-Promotor: T.J. de Jong

Modeling and analysis of cyber-physical systems are still challenging. One reason is that cyber-physical systems involve many different parts (cyber or physical), of different nature (discrete or continuous), and in constant interaction via sensing and actuating.

Promotor: Prof.dr. C.W.J. Beenakker

Promotor: Ed F. Deprettere, Co-promotor: Todor P. Stefanov

Promotor: Prof.dr. R. Verpoorte, Co-Promotores: N.R. Mustafa, A.E. Schulte

This thesis describes the development of improved formulations and alternative delivery strategies for polio vaccination.

Including modelling as part of software development appears to have various benefits.

This thesis involves three topics: benchmarking discrete optimization algorithms, empirical analyses of evolutionary computation, and automatic algorithm configuration.

One of the key limitations of the direct imaging of exoplanets at small angular separations are quasi-static speckles that originate from evolving non-common path aberrations (NCPA) to which the primary adaptive optics system is inherently blind. The main focus of this thesis is the development and…

This thesis is devoted to an in-depth examination of the various effects of disorder in the cuprate high-temperature superconductors.

Promotor: Jelle S. Kaastra Co-promotor: Jelle de Plaa

Duits is met 100 miljoen moedertaalsprekers de meest gesproken taal in de Europese Unie. Kennis over het Duitse taal- en cultuurgebied is onmisbaar om het huidige Europa en zijn geschiedenis te begrijpen. Het minorprogramma Duitse taal, cultuur en geschiedenis biedt studenten de basisvaardigheden die…

In this thesis,

Glucocorticoids are potent anti-inflammatory drugs widely used clinically to treat various inflammatory and immune conditions. However, two main clinical problems limit their use. GCs trigger severe side effects and they induce acquired glucocorticoid resistance, especially during chronic systemic treatment…

Control of infectious diseases poses continuous challenges for human health.

Promotoren: R. Tijdeman, A.K. Lenstra, Co-promotor: H.J.J. te Riele

This Thesis focuses on the design and synthesis of ADP-ribosylated compounds that can be applied in biological studies.

Op 11 november 2021 verdedigde Mariana Gkliati het proefschrift 'Systemic Accountability of the European Border and Coast Guard'. Het promotieonderzoek is begeleid door promotoren prof.dr. P. Rodrigues en prof.dr. L. Besselink (UvA).

The growing demand of energy indicates that global energy resources in the form of fossil fuels will not be sufficient in the future. In order to solve potential future energy problems development of a sustainable hydrogen economy is highly desirable.

In condensed matter systems electron-electron interactions, negligible in everyday metals, can dramatically alter the electronic behavior of the system. Examples of such altered behavior include high-temperature superconductivity and modulation of the electron density.

Heterogeneous catalysis is one of the fundamental processes of modern life, being common in industrial refinery and hydrogen vehicles, all the way to the living cell. The dissociation of H2 on Cu(111) is an important benchmark system for studying heterogeneous catalysis, with a large and varied amount…

The energy system is at the heart of two of the greatest challenges of the 21st century: decreasing CO2 emissions to meet the ambitions of the Paris agreement while fulfilling the growing energy demand associated with the economic aspirations of a growing world population.

In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.

Food waste is a defining inefficiency of the modern food system, with profound implications for resource use, climate change, and circular economy transitions. This dissertation examines food waste through two complementary lenses: the prevention of avoidable food waste and the valorization of unavoidable…

Promotor: Prof.dr. E.F. Smets. Co-promotores: B. Gravendeel, F. Pupulin

Microbiome composition of the spermosphere and the rhizosphere of wild and modern bean accessions grown in an agricultural and a native soil from Colombia was characterized by metagenomics and cultivation-dependent approaches.

Announcement of the publication of Vamping the Stage: Female Voices of Asian Modernities, the first book-length study of women, modernity, and popular music in Asia (University of Hawai'i Press, 2017).

Filamentous Actinobacteria, such as Streptomyces, produce a plethora of chemically diverse bioactive metabolites that have found applications across medicine, agriculture and biotechnology.

The physical origin of the dozens of stellar-mass binaries, the mergers of which have been detected by the LIGO-Virgo-KAGRA collaboration via gravitational waves, is still unknown.

Ice, the solid state of water, plays an important role on our planet as well as the entire universe.Despite the fact that an individual water molecule has a very simple structure, its chemical bonding in the solid phase can be surprisingly complex.

Promotor: Prof.dr. F.S. de Boer, Co-promotor: D. Clarke

Op 7 december 2021 verdedigde Georgina Kuipers het proefschrift 'Beschadigd vertrouwen'. Het promotieonderzoek is begeleid door prof.mr. W. den Ouden en prof.dr. M.A. van der Steen (EUR).

“Temminck’s Order” is the scientific biography of Coenraad Jacob Temminck (1778–1850), a Dutch naturalist and the first director of ’s Rijks Museum van Natuurlijke Historie in Leiden.

Promotor: Prof.dr. M.L. van Hecke, Co-Promotor: V. Vitelli

Classical statistical methods, such as p-values, are difficult for researchers to apply correctly. They for example do not allow drawing conclusions from a study early, or for extending a study with extra research groups that want to make their data available later.

Single-layer graphene (SLG) has attracted considerable interest as a proton exchange membrane for direct methanol fuel cells (DMFCs), owing to its atomic thickness, mechanical robustness, and unique proton permeability.

This thesis investigates reactive interfaces in surface science across three domains: heterogeneous catalysis, environmental nanoplastics, and two-dimensional materials.

Het HOVO van de Universiteit Leiden biedt colleges op universitair niveau voor mensen met vijftig jaar levenservaring. Er zijn collegereeksen op het gebied van de geesteswetenschappen, de sociale wetenschappen en de natuurwetenschappen. Het programma van colleges kunt u vinden onder Collegeaanbod

En de bouw is gestart! Studenten van de studieverenigingen van de faculteit Wiskunde en Natuurwetenschappen sloegen dinsdagochtend samen de eerste palen in de grond. Zo startten ze de tweede fase van de bouw van het Gorlaeus Gebouw.

Op 1 september 2015 geeft assessor Sanne Grootveld het stokje door aan Aurelie van ’t Slot (22). Deze masterstudente zal dit academisch jaar als nieuwe assessor van Geesteswetenschappen de belangen van studenten in het faculteitsbestuur gaan behartigen. Wie is Aurelie van ‘t Slot? Even kennismaken met…

Universiteiten moeten niet verbaasd zijn dat studenten ChatGPT gebruiken, schrijven de Leidse universitair docenten Femke Klaver en Alexander de Wit in Trouw. Want studenten reageren op efficiëntie en doelmatigheid. Hun suggestie: Leid studenten op om kritisch na te denken.

Voor het vijfde jaar op rij gaven Leidse professoren op de dies natalis les op basisscholen bij “Meet the professor”.

Lang was de Nederlands-Indische literatuur niet meer dan een ‘exotisch stiefkind’ van de Nederlandse literatuurgeschiedenis. Dat veranderde met de publicatie ‘Oost-Indische spiegel’ (1972) van Rob Nieuwenhuys en leidde tot de oprichting van de Werkgroep Indisch-Nederlandse Letterkunde. Inmiddels bestaat…

Op 20 januari 2017 vond er een NSE Discussie Lunch plaats, georganiseerd door „Aesculapius” in samenwerking met de opleiding. Tijdens deze bijeenkomsten konden studenten en docenten discussiëren over de resultaten van de Nationale Studenten Enquête 2016.

Tijdens de opening van het academisch jaar wordt traditiegetrouw de LUS Onderwijsprijs uitgereikt aan de beste docent op de universiteit. Maak kennis met de genomineerden. Deze week: Thijs Porck.