The intracluster medium (ICM) is a hot, tenuous and X-ray emitting gas that pervades galaxy clusters.

Onderzoekers werken al eeuwen aan een atlas van het brein. Maar zelfs in 2017 zijn sommige hersenstructuren nog niet in kaart gebracht, met name in de hersenstam. In dit paper hebben we de test-hertest betrouwbaarheid gemeten van de enige MRI-scan die onderzoekers in staat stelt om de locus ceruleus,…

Light-Harvesting Complex II (LHCII) is responsible for light absorption and excitation energy transfer in plants and photosynthetic algae, while in high light it undergoes conformational changes by which it quenches excitations to prevent photodamage.

Op 23 juni 2020 verdedigde Santy Kouwagam haar proefschrift 'How lawyers win land conflicts for corporations: Legal Strategy and its influence on the Rule of Law in Indonesia'. Het promotieonderzoek is begeleid door promotoren prof.dr. A.W. Bedner en prof.dr. C.E. von Benda-Beckmann.

Promotor: Prof.dr. H.V.J. Linnartz, Co-Promotores: S. Ioppolo, H.M. Cuppen

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

Dit op casestudies gebaseerde Engelstalige boek over multivariate analyse voor gevorderde studenten in de geesteswetenschappen legt de nadruk op beschrijvende, exploratieve analyses van verschillende soorten datasets uit een breed scala van subdisciplines, waarbij het gebruik van multivariate analyse…

Carbohydrates are present on the surface of bacteria making them suitable antigen candidates for vaccine development. This thesis deals with the synthesis of two carbohydrate-based components; the capsular polisaccharide of S. aureus type 5 and teichoic acids from staphilococci and enterococci speci…

There is a need for alternative methods to replace, reduce and refine (3R) animal experimentation. Combining experimental data from high-throughput in vitro studies with in silico modeling is a promising approach to unravel the effect of chemicals on living cells and to gain a better understanding of…

In this thesis we investigated the ability of two-photon multifocal microscopy for single-molecule microscopy in live cells and organisms.

This dissertation focused on computational methods based on first principles calculations using the Density Functional Theory (DFT) framework. Emphasis was laid on affordable methods that can provide a tradeoff between computational expense and accuracy.

Promotor: H.J.A. Röttgering, Co-promotor: G.K. Miley

Today, knowledge is the most crucial element to stimulate organizational competitiveness and economic development.

Promotor: A.P.IJzerman, Co-Promotor: L.H. Heitman

Because thin systems can deform along the thickness with relative ease, the interplay between surface mechanics and geometry plays a fundamental role in sculpting their three-dimensional shape.

Automated Machine Learning (AutoML) is widely used to automatically build a suitable practical Machine Learning (ML) model for an arbitrary real-world problem, reducing the effort of practitioners in the ML development cycle for real-world applications. Optimization is a key part of a typical AutoML…

The Sun and all the stars in the night sky reside in the Milky Way galaxy. In the at-rest reference frame of the Galaxy, typical stars travel with velocities of about 100-200 kilometres per second.

In the traditional theory of linear elasticity, superposition dictates that the response of a material does not depend on the sequence of the applied mechanical actuations.

During the course of drug discovery translational steps are made.

Promotor: Erik F. Smets, Co-promotores: Barbara Gravendeel, Niels Raes

The focus of this thesis is on the technical methods which help promote the movement towards Trustworthy AI, specifically within the Inspectorate of the Netherlands.

This Thesis describes the design, synthesis and evaluation as glycoprocessing enzyme inhibitors of focused libraries of iminosugars.

Leiden University offers a unique range of summer courses where you can broaden or deepen your knowledge or share your expertise with fellow students. The choice of academic courses is very diverse, ranging from Law, Big Data, Languages and Linguistics to Maths and Natural Sciences, Biology, Biomedical…

This thesis describes the importance of being able to control the selectivity of potential drug candidates.

This thesis develops a method for direction dependent calibration of the ionosphere in radio interferometric data.

Promotor: Prof.dr. H.A.G. Wijshoff

This thesis explores squaramide-based supramolecular polymers and hydrogels, enhancing their mechanical strength for 3D cell culture.

The research presented in this thesis explores the chemotherapeutic potential of metal-based compounds as chemotherapy agents, with an initial focus on the synthesis and DNA interaction studies of platinum and palladium compounds utilizing the [Pt(bapbpy)]2+ scaffold. The study identifies intercalation…

The aim of this thesis is to explore the use of Bioorthogonal Antigens to study the cross-presentation pathway.

This dissertation is part of a broader research project that revolves around unraveling the evolution of balanced lethal systems.

Promotor: K.H. Kuijken

Promotor: Prof.dr. H.L.V. Linnartz

Promotor: Prof.dr. E.F. van Dishoeck, Co-Promotor: G.J. Herczeg

Promotores: Prof.dr. M. Franx, Prof.dr. M. Kriek (Univ. of California at Berkeley)

Quantum computers are a proposed fundamentally new type of computer. They aim to perform some computations much faster than previously possible by exploiting phenomena at the quantum scale, called superposition and entanglement.

Galaxies in the Universe are distributed along the intricate framework of the Cosmic Web. Groups and clusters of galaxies comprise the densest regions in this network, and therefore, are excellent cosmic laboratories to study different aspects of galaxy evolution in extreme environments.

Promotores: Prof.dr. M. Franx, Prof.dr. P.G. van Dokkum (Yale University)

In this thesis we have discussed several parameters that affect the electrochemical conversion of enviromentaly harmful molecules such as nitrates and carbon dioxide to more valuable and less deleterious compounds, in order to cast light onto the mechanism of the reaction to achieve an efficient and…

The use of increasingly large and diverse datasets to guide urban climate action has implications for how, and by whom, local governments are held accountable.

The thesis is about the study of shell evolution of the Hydrocenidae of the genus Georissa. This thesis started with a general overview on the evolutionary process of animals due to ecological changes.

Promotor: M.T.M. Koper, Co-Promotor: L.B.F. Juurlink

CT scanning of skeletal remains can tell us about how strong or weak a persons bones were and we can relate that back to diet, activity, and reproductive factors.

The database research community has made tremendous strides in developing powerful database engines that allow for efficient analytical query processing.

N-acylethanolamines (NAEs), including N-arachidonoylethanolamine (anandamide, AEA), N-palmitoylethanolamine (PEA) and N-oleoylethanolamine (OEA), are signaling lipids that play an important role in different physiological process.

The main theme of this thesis is the theoretical study of Gaussian processes as a tool in Bayesian nonparametric statistics.

In the era of big data, extracting insights from complex datasets is a key challenge. This thesis demonstrates the superiority of graph-based methods over traditional clustering (e.g., k-means, DBSCAN) and outlier detection for analyzing high-dimensional and noisy data.

This doctoral thesis is an effort to understand how lipid phase-separation induced by diacylglycerol analogues in lipid-based nanoparticles affects their in vivo behavior, leading to specific nanoparticle-protein communications and selective cell targeting.

The aim of this thesis was to develop novel treatment strategies for different types of eye melanoma utilizing zebrafish models. We first establish orthotopic and ectopic xenograft models for uveal and conjunctival melanoma by engraftment of the immortalized cells derived from these tumors into zebrafish…

Promotor: Prof.dr. M. Franx, Co-Promotor: Rychard Bouwens

This thesis concerns the relation bettween the good reduction of Shimura varieties and the associated loop groups.