Promotor: T. Hankemeier, Co-promotor: R.J. Vreeken

De BioMedical Metabolomics Facility Leiden (BMFL) biedt een zeer gestructureerde omgeving voor geavanceerd metobolomicsonderzoek. BMFL is gebaseerd op volledig gevalideerde, moderne platforms die gezamenlijk het gehele menselijke metabolisme beslaan.

Voor je profielwerkstuk (PWS) ga je een eigen onderzoek doen. Een mooie voorbereiding op je latere studie! Wil je meer weten over hoe je dat aanpakt, of zoek je nog naar een onderwerp? Het Loket Profielwerkstukken biedt hulp in de vorm van informatie en inspiratie. Je kunt ons ook vragen stellen.&nb…

In this book liposomes are explored as delivery system for allergen-specific immunotherapy. Both cationic and anionic formulations are prepared with Bet v 1, one of the allergens in birch pollen.

Sinds de oprichting is LUC een college voor onderwijsontwikkeling en experimentatie. In de missie van het college wordt LUC beschreven als "een plek van innovatie op het gebied van didactiek, curriculumontwerp en studentwelzijn." Deze visie wordt toegepast via een studentgerichte benadering in het onderwijs…

De Young Academy Leiden (YAL) is een selecte groep jonge academici aan de Universiteit Leiden. De YAL, opgericht in begin 2019, dient als platform om enthousiaste en ambitieuze jonge academici (post-PhD), die aan het begin van hun carrière staan, bij elkaar te brengen. YAL-leden vertegenwoordigen…

Hoe beïnvloedt de vernietiging van universiteiten in Gaza, ook wel 'scholasticide' genoemd, het wetenschappelijk leven en wat zijn de theoretische en juridische onderbouwingen van de term?

Je kiest voor de studie Bio-Farmaceutische Wetenschappen wanneer je sterk geïnteresseerd bent in de ontwikkeling van en het onderzoek naar de werking van geneesmiddelen.

The research presented in this thesis concerns one of the most important questions in software engineering of our time: how can we make sure that software is free from memory safety bugs?

Onderzoekers vanuit verschillende vakgebieden werken samen om oplossingen te bedenken voor maatschappelijke problemen.

With an emphasis on developing novel miktoarm star polymers termed PeptoMiktoStars, this thesis leverages asymmetric polymeric polypept(o)ide frameworks to advance their effectiveness in delivering hydrophobic drugs and nucleic acids.

Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.

In this research project, we aimed to obtain more insight in the role of mast cells in the immune driven disorders rheumatoid arthritis and atherosclerosis.

Accurate prediction of the unbound drug concentration-time profile at the CNS target site is crucial for the assessment of the right drug concentration-effect relationship. PBPK models have supported the PK prediction of the CNS target sites and the translation of PK data between species and between…

In this thesis, we developed new ways to use a technique called electroextraction (EE) to extract charged molecules from one liquid into another using an electric field.

Explaining treatment response variability between and within patients can support treatment and dosing optimization, to improve treatment of individual patients.

Despite being the second largest transmembrane protein family after GPCRs, the SLC superfamily has only gained significant attention in early drug development over the past decade.

In this thesis, we aim to shed light on the diverse and often opposing roles of integrin α3β1 in cancer.

This thesis explored the molecular pharmacological mechanisms of targeting CB2R via investigation of novel drug discovery concepts such as target binding kinetics, allosteric modulation and biased signaling.

This thesis describes the importance of being able to control the selectivity of potential drug candidates.

During the course of drug discovery translational steps are made.

Cardiovascular diseases are still a major concern for the global health.

Promotor: A.P.IJzerman Co-promotor: A. Bender

In previous studies at our laboratory it was demonstrated that drug exposure of HepG2 cells can lead to an altered TNFα-induced NF-κB oscillatory phenotype, concurrent with a synergistically increased sensitivity for TNFα-induced apoptosis.

Promotores:Th.J.C. van Berkel, M. van Eck

The ideas underlying this thesis are that lipidomics may improve the diagnosis of liver metabolic diseases, and can provide further insights into the underlying pathophysiology of these diseases.

There is an increasing amount of attention on EU and its Member States contributions to implementation of two landmark agreements: the Paris Climate Agreement and the UN Agenda 2030 with Sustainable Development Goals (SDGs). Absent from the current literature is an analysis of the political effect of…

Hier vindt u links naar diverse pagina's die scholieren ondersteunen en stimuleren bij het maken van hun profielwerkstuk.

Metabolomics is a powerful tool that can provide a comprehensive insight into the complexity of human biology and the pathophysiology of diseases. By analyzing the metabolome, which refers to the complete set of small (endogenous) molecules (with a mass <1500 Da) present within a given biological system,…

Promotor: B. van de Water, Co-promotor: E.H.J. Danen

Promotor: A.P.IJzerman, Co-Promotor: L.H. Heitman

Promotores: C.A.J. Knibbe, D. Tibboel, Co-Promotor: P. Bruins

Pericytes, the mural cells of blood microvessels, are important regulators of vascular morphogenesis and function that have been postulated to mechanically control microvascular diameter through as yet unknown mechanisms.

There is a need for alternative methods to replace, reduce and refine (3R) animal experimentation. Combining experimental data from high-throughput in vitro studies with in silico modeling is a promising approach to unravel the effect of chemicals on living cells and to gain a better understanding of…

In this thesis, we focus on novel proteins/mechanisms that regulate integrin-adhesion mediated mechano-transduction.

Lipid signaling is an essential biological event/process in a plethora of pathophysiological conditions. The underlying idea of this thesis is that many of the roles and the complex interplay of the individual signaling lipids in inflammatory processes and related conditions in health and disease is…

Welke relatie bestaat er tussen verschillende type PLGs en cognitieve differentiatie?

Metabolomics has the potential to play a pivotal role in understanding disease onset and progression, and ultimately personalized treatments. One of its major challenges is its large-scale implementation, which is necessary to deal with the high variability of the metabolome. In this work we have developed…

The challenge of achieving fast quantification in metabolomics is the presence of severe matrix effects during the MS analysis of complex samples.

Promotor: W. Jiskoot, Co-promotor: A. Kros

Data theory research on the analysis on the multidimensional data

This thesis focuses on data found in the field of computational drug discovery. New insight can be obtained by applying machine learning in various ways and in a variety of domains. Two studies delved into the application of proteochemometrics (PCM), a machine learning technique that can be used to…

Vakdidactiek bedrijfseconomie, ondernemerschap en financiële zelfredzaamheid

Het fundamentele recht op ‘vrijheid van de kunsten en het wetenschappelijk onderzoek’ in de EU: een verkenning van de grenzen van de commercialisering van de academie (AFITE).

De keten die patiënten voorziet van nieuwe medicijnen, bestaat uit diverse complexe schakels: van fundamentele wetenschap, tot klinische tests, tot productie. Deze hele keten is aanwezig in Leiden. De Universiteit Leiden, het Leids Universitair Medisch Centrum (LUMC) en de bedrijven op het Leiden Bio…