This project uses archaeological, literary and epigraphic evidence to investigate urban development in Roman-period North Africa, compiling this in a GIS-linked database in order to analyse the development of urban settlement spatially over time.

Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.

The work presented in this thesis is based on ALMA surveys of protoplanetary disks in three star-forming regions: Lupus, OMC-2, and NGC 2024.

The research described in this thesis centered on retaining exo-β-glucosidases implicated in health and disease, in particular the human inherited lysosomal storage disorder, Gaucher disease (GD).

International trade has played a major role in defining the modern global economy. Trade, however, entangles the environmental pressures of economic sectors, giving the illusion of environmental improvements, while the opposite may be occurring.

This ecological community has long been known to affect host biology, and their diverse roles have been further clarified in recent years following numerous studies of animal:microbiota interactions in diverse systems.

This thesis aims to enhance our understanding of galaxies by testing theoretical models of galaxy formation against observations, particularly in the cases of extreme systems which have been found to have an excess of baryonic mass in their central regions, in the form of either supermassive black holes…

A new publication on changes in the relationship between news and their public in Chile

Carbon dioxide capture and utilization technologies are necessary to create a truly circular economy. The electrochemical reduction of carbon dioxide to formate is an appealing carbon utilization method as it can be performed at room temperature and pressure, it only requires two electrons, and it has…

Promotor: T. Hankemeier, Co-Promotores: T. Reijmers, L. Coulier

Promotor: Prof.dr. E.F. Smets, Co-Promotor: L.W. Chatrou

The overall theme of this thesis is to complement the electrochemical data acquired in fuel cell research with in situ X-ray photoelectron spectroscopy (XPS) and soft X-ray absorption spectroscopy (XAS).

Promotor: Prof.dr. W.T.F. den Hollander

Promotor: J. Zaanen

Promotor: Prof.dr. E Gittenberger, Co-Promotores: C.H.J.M. Fransen, B.W. Hoeksema

Promotor: Prof.dr. T.H.W. Bäck

Continuous optimization is never easy: the exact solution is always a luxury demand and the theory of it is not always analytical and elegant.

Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.

Promotor: C.J. ten Cate

Pseudomonas Aeruginosa is a Gram-negative bacterium which can form biofilms, increasing its resistance against antibiotics and the host immune system. Polysaccharides are an integral part of this biofilm, one of these polysaccharides is called Psl. PslG is a glycosidase, able to cleave this polysaccharide,…

The Standard Model (SM) of particle physics fails to explain several observed phenomena and is incomplete. In order to resolve this problem, one may extend the SM by adding new particles.

Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.

Tracing the evolution of the molecular gas content in galaxies is critical for a complete understanding of galaxy formation and evolution, as it provides the direct fuel for star formation. Studies of high-redshift (z>1) molecular gas reservoirs, most commonly traced by carbon monoxide (CO), have seen…

Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.

Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.

There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.

This thesis applies data mining in commercial settings in the telecommunications industry.

Promotor: J.N. Kok, Co-promotor: C.M. Soares, A.J. Knobbe

This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.

Promotor: A. Kros

A remarkable population of short period transiting rocky exoplanets with equilibrium temperatures on the order of 2,000 K has recently been discovered.

Promotor: Prof.dr. J.G.E.M. Fraaije, Co-promotor: A. Kros

Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.

Plastics have become an integral part of modern society due to their versatility and durability.

The formation and evolution of galaxies is fundamentally driven by the formation of new stars out of cold gas.

In dit project wordt onderzocht hoe onderzoek in de leeromgeving (Research Based Learning of RBL) studenten kan stimuleren om zelf onderzoek te gaan doen. Ook wordt gekeken naar het effect van RBL op het vermogen van studenten om kritisch te denken en op hun academische vaardigheden.

uman skin equivalents (HSEs) are in vitro 3D-skin models that mimic many aspects of the native human skin (NHS) and can be a valuable tool.

Prikkelende vragen stellen om de verdieping op te zoeken, zo ziet Stella Trompet haar studenten groeien. Ze is docent bij de halve minor en master Health, Ageing and Society van het LUMC/Universiteit Leiden. Haar enthousiasme brengt ze over op haar studenten, want ouderen zitten niet achter de geraniums,…

Promotor: H.J.A. Rottgering, Co-Promotor: R.J. van Weeren

Discover the master program population Health Management at Leiden University and contribute to a more integrated health care system. Learn more!

In this course, we will focus on the fascinating history of the Arabic Medieval World. We will take you on a journey through the Middle Ages. All along, we will present you with historiographical debates and dilemmas and travel back and forth in time explaining to you how events of the past affected…

Promotie

The ultimate aim of this project (initiated by the European Law Institute) is to design a framework that will enable the further development of coherent and functional rules for business rescue in Europe.

Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia

Multicellular giant algae Chara species have been widely used in physiological studies for decades.

Promotor: Prof.dr. M. Ubbink

Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater