423 zoekresultaten voor “ben cancer” in de Publieke website
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Sexual rehabilitation after radiotherapy for gynaecological cancers
Promotie
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Immune and Metabolic Dysregulation in Liver Cancer
Promotie
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'Behandeling van kanker moet ‘slechts’ een levensgebeurtenis van zes weken worden'
Toen Christian Blank zijn allereerste ontdekking deed was de immuuntherapie, het onderzoeksgebied van deze internist, het sufferdje van het kankeronderzoek. Nu, ruim twintig jaar later, is Blank benoemd tot bijzonder hoogleraar Interne Geneeskunde voor zijn klinisch onderzoek naar immunotherapie. Oratie…
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Nieuwe hoogleraar gaat medicijnen ontwikkelen binnen academische wereld
Internist- klinisch farmacoloog Teun van Gelder is per 1 december 2019 benoemd tot Leidse hoogleraar Drug Discovery & Development. Hij zal zich bezighouden met het ontwikkelen van geneesmiddelen binnen de academische wereld, ook wel Academic Pharma genoemd.
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Click-to-release for immune cell activation
This work describes the use of click-to-release chemistry to get spatiotemporal control over immunocytokine activity. Until now, immunocytokines (cytokines coupled to a tumor-targeting-moiety) remained active throughout the body, being able to bind their respective receptors, causing mild to severe…
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The road to insurmountability: Novel avenues to better target CC Chemokine receptors
This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.
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From every angle: novel insights into CC chemokine receptor 2 pharmacology
The CC chemokine receptor 2 (CCR2), a member of the G protein-coupled receptor (GPCR) superfamily, is widely involved in autoimmune and inflammatory diseases. However, no drugs for this receptor have made it to the pharmaceutical market yet.
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Mitochondria in chemical-induced toxicity
Chemical-induced organ toxicity is a major concern in the development and use of chemicals, including drugs, pesticides, industrial chemicals and cosmetics. In the last decades, the onset and progression of chemical-induced organ toxicity has been linked amongst others to perturbation of mitochondri…
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Synthetic Methodology Towards ADP-Ribosylation Related Molecular Tools
Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.
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High throughput microscopy of mechanism-based reporters in druginduced liver injury
Promotor: B. van de Water
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Protein arginine methyltransferases as modulators of lipid metabolism and inflammation and the relevance for atherosclerosis
Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…
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Osteosarcoma: searching for new treatment options
Promotores: B. van de Water; P. Hogendoorn; J. Bovée Co-Promotor: E.H.J. Danen
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Synthesis of chemical tools to study the immune system
This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.
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Exploring chemical space in covalent and competitive glycosidase inhibitor design
Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency
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The Role of Linker DNA in Chromatin Fibers
The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.
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More is alive: emergent multi-scale order & collective flows in tissues
The overarching goal of this thesis is to set the foundations, but also make the first essential steps towards establishing a comprehensive, mesoscopic, hydrodynamic theory of epithelial tissues. The stage is set by an exhaustive study of topological defects in passive p-atic liquid crystals, singularities…
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Synthetic carbohydrate ligands for immune receptors
One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.
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Discovery of Reversible Monoacylglycerol Lipase Inhibitors
Monoacylglycerol lipase (MAGL) is the principal enzyme responsible for hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-AG). MAGL inhibition provides several potential therapeutic opportunities, including anti-nociceptive, anti-inflammatory and anti-cancer activity.
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Evaluation of the zebrafish embryo as an alternative model for hepatotoxicity testing
Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis
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Ben Lugtenbergb.j.j.lugtenberg@biology.leidenuniv.nl | 071 5275063
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Ben Cohlenb.j.cohlen@lumc.nl | 071 5269111
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Ben Nieuwenhuysb.e.nieuwenhuys@chem.leidenuniv.nl | 071 5274269
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Ben SmitICLON
smit@iclon.leidenuniv.nl | 071 5272727
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Ben ArpsFaculteit der Geesteswetenschappen
b.arps@hum.leidenuniv.nl | 071 5272222
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Ben Wangbwang@strw.leidenuniv.nl | 071 5272727
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Ben KuipersFaculteit Governance and Global Affairs
b.s.kuipers@fgga.leidenuniv.nl | 070 8009978
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Ben Desloover
Faculteit der Rechtsgeleerdheid
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Ben van Rossen
b.van.rossen@sea.leidenuniv.nl | 071 5272727
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Ben HaringFaculteit der Geesteswetenschappen
b.j.j.haring@hum.leidenuniv.nl | 071 5274170
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Ben van der Weijden
Universitair Facilitair Bedrijf
b.van.der.weijden@ufb.leidenuniv.nl | 070 8009500
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Ben van VelthovenFaculteit der Rechtsgeleerdheid
b.c.j.vanvelthoven@law.leidenuniv.nl | 071 5271571
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Ben CompanjenUniversitaire Bibliotheken Leiden
b.a.companjen@library.leidenuniv.nl | 071 5278858
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Ben SchoenmakerFaculteit der Geesteswetenschappen
b.schoenmaker@hum.leidenuniv.nl | 071 5271646
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Ben van Werkhovenb.van.werkhoven@liacs.leidenuniv.nl | 071 5272727
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Ben Wielstrab.m.wielstra@biology.leidenuniv.nl | 071 5275135
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Ben Ganschow
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Towards the Prevention of Cancer Treatment Related Hearing Loss
Promotie
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Understanding anthracycline action: molecular insights to improve cancer therapy
Promotie
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Optimizing cancer care through e-health: status, potential, and adoption
Promotie
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Risk assessment tools and adjuvant therapy for breast cancer
Promotie
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Identifying novel genetic causes of familial colorectal cancer
Promotie
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Insights into gastric cancer: towards tailored surveillance and treatment strategies
Promotie
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T-cell gene therapy for low mutational burden cancer
Promotie
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Risk assessment tools and adjuvant therapy for breast cancer
Promotie
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On preoperative systemic treatment of muscle-invasive bladder cancer
Promotie
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Improving CD3 bispecific antibody therapy for solid cancer
Promotie
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Blueprints of Disease: Precision Platforms for Modelling Breast Cancer
Promotie
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Understanding BRCA1(-complexes) in DNA repair and cancer
Promotie
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The Use of 3D Skin Equivalents Mimicking Skin Cancers
Promotie
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Predicting and evaluating side effects of radiotherapy in cervical cancer
Promotie