Promotors: Prof.dr. E. Bouwman, Prof.dr. E. Drent

Photocatalysis has emerged as a powerful tool for enabling challenging transformations in organic synthesis. This thesis explores the development of several photocatalytic reactions designed to form carbon-heteroatom bonds from less-functionalized precursors.

Indonesia is experiencing various environmental challenges related to its fast economic growth. Therefore, it is necessary to have measurable and applicable indicators to obtain accurate data and information regarding the costs of adverse environmental impacts arising from economic activities to support…

A neurocognitive investigation of the development of social performance monitoring in youth growing up in stressful versus non-stressful environments

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

Binnen de sectie Gezondheids-, Medische en Neuropsychologie wordt onderwijs verzorgd en onderzoek verricht op verwante deelgebieden van de psychologie: Gezondheids-, Medische en Neuropsychologie.

Promotor: C.A.J. Knibbe, Co-promotor: J.J. Boelens, R.G.M. Bredius

The deeper understanding of an organism's pathology is important for developing treatments. Over centuries of systematic research, clinical researchers have demonstrated that the more information they acquire about the cellular properties and their organisation in the tissue, the better they can understand…

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

This thesis investigated miniaturized mass spectrometry (MS)-based analytical methods to address challenges in analyzing biomass-restricted biological samples.

Promotores: J. Jonkers, K.E. de Visser

This dissertation focuses on developing new mathematical and statistical methods to properly represent time-varying covariates and model them within the context of time-to-event analysis.

Het doel van dit onderzoek is om de bijwerkingen tijdens de behandeling met methylfenidaat in kaart te brengen en te onderzoeken hoe kinderen het gebruik van het medicijn (zoals Ritalin, Concerta en Medikinet) ervaren.

Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.

In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

We found that, next to the effectiveness of the intervention, it’s also very likely that the intervention is cost-effective compared to attention only.

Transcutaneous vagus nerve stimulation (tVNS) was tested in chronic worriers. tVNS may reduce spontaneously occurring negative thought intrusions. After a worry induction, there was no longer an effect of tVNS. tVNS did not affect physiological responding to worrying.

Kunstmatige fotosynthese heeft als doel om via chemische processen zonne-energie om te zettn in brandstof. Semi-kunstmatige fotosynthese is een hybride aanpak waarbij chemische maar ook biotechnologische processen worden gebruikt. Wij hebben als doel om een hybride systeem te ontwikkelen met behulp…

Tot wel 50% van de mensen met de ziekte van Parkinson ontwikkelt na verloop van tijd cognitieve achteruitgang; deze studie onderzoekt het gebruik van ‘oefeneffecten’ op neuropsychologische tests als een vroege voorspeller van cognitieve achteruitgang.

Seksueel misbruik van kinderen is een veelvoorkomend probleem: wereldwijd wordt ongeveer één op de vijf meisjes en één op de dertien jongens vóór hun achttiende jaar slachtoffer van een vorm van seksueel misbruik. Ondanks de hoge prevalentie zwijgen veel slachtoffers over deze ervaringen en wachten…

Scattering of light in the presence of nano-structured materials, i.e. with features in the order of the wavelength of the light or smaller, reveals details of how light interacts with matter at the nanoscale.

The external tissues of plants and animals are colonized by microbial communities termed microbiota. When organisms are exposed to environmental pollutants, these substances will therefore encounter microbiota at the exposure interface.

Human civilization consumes a huge amount of fossil fuels, which has resulted in an atmospheric CO2 level which has not been higher in over 800 millennia.

Promotores: G.W. Canters, T.J. Aartsma

With the energy transition toward a renewable energy supply and a CO2-neutral economy, electrification of the energy system is rising in importance, which leads to the challenge of long-term storage of renewable electricity.

This thesis studied in depth the energy use and CO2 emissions of the industrial sector in China.

Hydrocarbonylation of alkenes with carboxylic acids in synthesis of carboxylic acid anhydrides is relatively less explored. We herein present a study and optimization of a palladium-catalyzed hydrocarbonylation reaction of alkenes using carboxylic acids as the nucleophile, by which acid anhydrides can…

Biopolymer sequencing with graphene edge-based tunnel junctions has the potential to overcome current limitations with the third generation of sequencing based on biological nanopores.

In this dissertation iron-based homogeneous catalysts were synthesized, characterized and investigated for water oxidation activity.

Cardiovascular diseases (CVDs) are the leading global cause of mortality. Endothelial dysfunction, an early reversible stage of CVD development, is marked by decreased nitric oxide production linked to Ca2+ influx in endothelial cells.

The goal of the research presented in this thesis was to explore the chemical space of ruthenium(II) photocages, investigate their ability to host potent chemotherapy drugs, and to red shift the activation wavelength of the most promising PACT candidates to conduct biological studies.

The electrochemical oxygen reduction reaction (ORR) is an essential half-reaction for the utilization of hydrogen as a sustainable fuel, via the conversion of hydrogen to electrons and protons facilitated by the ORR. In the most common fuel cells, the ORR is requires high loadings of non-abundant platinum…

Promotor: M.T.M. Koper, Co-promotor: J.B.F. Juurlink

Producing green energy has become the main goal in our society in the search of reducing or eliminating the carbon emission from fossil fuels.

This thesis presents insights from our study of various correlated electron systems with a scanning tunneling microscope (STM). In ordinary metals, electron-electron interactions exist, but get substantially screened due to the sheer number of electrons.

Promotor: Prof.dr. H.J.A. Rottgering

In condensed matter systems electron-electron interactions, negligible in everyday metals, can dramatically alter the electronic behavior of the system. Examples of such altered behavior include high-temperature superconductivity and modulation of the electron density.

This thesis addresses the challenge of sustainable urban development by analyzing the interplay between green and grey infrastructure to optimize resource use and ecosystem services.

Structural variants (SVs) are the hidden architecture of the human genome, and are critical for us to understand diseases, evolution, and so on.

Integratie van MOOC in campus

Artificial photosynthesis has recognised potential to produce green and sustainable fuels from earth-abundant resources such as water, carbon dioxide (CO2), and sunlight.

Promotor: E. Bouwman, Co-promotor: S. Bonnet

Promotor: Prof.dr. J.W.M. Frenken

Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet

Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet

In het onderzoek “Zwijgen over seksueel misbruik” kijken we naar hoe het gaat met mensen die seksueel misbruik hebben meegemaakt en daar nog nooit over gesproken hebben (m.u.v. eventueel een hulpverlener).

The aims of the project are to: further clarify 'inhibition by safety'; explore and describe all possible sagety factors, with a special focus on the primary human safety source: social connectedness; reviewing prolonged stress responses without stressors.

Optimalisatie, werkingsmechanismen en voorspellers van het resultaat van lichttherapie bij depressie: Een multicenter gerandomiseerde trial

Welke rol spelen ouder-kind interacties bij het ontstaan, in stand houden en de behandeling van depressieve klachten van jongeren?