We have studied shape with a particular focus on the zebrafish model system. The shape is an essential appearance of the phenotype of a biological specimen and it can be used to read out a current state or response or to study gene expression.

Vanaf de koloniale tijd tot heden hebben grote aantallen Javanen hun woonplaats verlaten om zich in andere delen van Indonesië of veel verder weg te vestigen. Vaak was deze spreiding gedwongen, vaak met traumatische gevolgen.

Over the past years it has been discovered that the population of extra-solar planets is large and diverse.

The investigations described in this thesis lay out strategies aimed at advancing antibiotic research and development. The examples presented revolve around two main approaches: understanding drug-target interactions and target identification.

Promotor: H.J.A. Röttgering, Co-promotor: M. Haverkorn

Prematurely born neonates require, amongst others, pharmaceutical therapy. Dosing guidelines for these therapies are often based on data from term born neonates or older infants, while these are not necessarily similar to prematurely born neonates.

This thesis addresses the chemical processes that determine the compositions of giant planet atmospheres.

This thesis presents insights from our study of various correlated electron systems with a scanning tunneling microscope (STM). In ordinary metals, electron-electron interactions exist, but get substantially screened due to the sheer number of electrons.

This Thesis describes the synthesis of D-alanylated ribitol-based wall teichoic acids from S. aureus to probe their interaction with immune-binding partners.

Promotor: Prof.dr. A.G.G.M. Tielens, Prof.dr. C. Dominik (UvA)

In this Yearbook you will find some fascinating examples of what was done in 2021, not only by ourselves, but also by our international colleagues.

Jelena Vićić en Richard Harknett bieden een analytische constructie om het functioneren van cyberbeïnvloedingsoperaties beter te begrijpen

In dit artikel bespreken Joachim Koops en Christian Patz de uitgebreide beoordeling van de Duitse gereedheid op het gebied van 'Protection of Civilians' (PoC).

Promotor: Prof.dr. M. Danhof, Co-promotor: O.E. Della Pasqua

Irene Khan, expert op het gebied van mensenrechten, werpt een aantal vragen op: Wat kan men verstaan onder een ‘Culture of Justice’? Wie bepaalt wat 'Justice' is? Hoe realistisch is de bevordering van ‘Rule of Law’ en ‘Justice’ in landen waar sprake is van ernstige conflictsituaties en armoede?

Why do sexual violence policies still fail to systematically address men and masculinities, when the need for cultural change among men has been central in public debates since #MeToo?

In september 2017 start de nieuwe Engelstalige bachelor Security Studies in Den Haag. Het onderwijsprogramma is uniek en is ontwikkeld door het Institute of Security and Global Affairs van de faculteit Governance and Global Affairs. Er is grote behoefte aan breed opgeleide academici in dit domein.

Dit artikel illustreert hoe de term 'dual use' geassocieerd is geraakt met een bredere dichotomie tussen 'legitieme' en 'illegale' doeleinden.

Op maandag 4 september is de nieuwe bacheloropleiding Security Studies officieel van start gegaan.

Promotores: R. Cramer, A.K. Lenstra, Co-Promotor: B.M.M. de Weger

With an emphasis on developing novel miktoarm star polymers termed PeptoMiktoStars, this thesis leverages asymmetric polymeric polypept(o)ide frameworks to advance their effectiveness in delivering hydrophobic drugs and nucleic acids.

To meet the rising demand for minerals driven by the global shift to clean energy technologies, ensuring responsible and resilient supply chains is critical. Minerals like cobalt, lithium, and nickel for batteries, neodymium and zinc for wind turbines, and indium for solar panels are essential.

Researchers from the Department of Economics - Kees Goudswaard, Koen Caminada, Marike Knoef, Pierre Koning and Olaf van Vliet - have been awarded a grant of one million euros by Instituut Gak to investigate self-sufficiency and social protection.

Humans can see the world through the eyes of other humans and imagine what they know, want, and intend. This competence is known as Theory of Mind.

Freshwater is an important resource, but at a great risk of species decline due to habitat loss, pollution and over-exploitation, and invasive alien species.

In deze publicatie worden problemen met betrekking tot de grensoverschrijdende afwikkeling van financiële instellingen onderzocht.

The increasing resistance of pathogenic bacteria to antibiotics necessitates the discovery of new medicines.

In this thesis, we aim to shed light on the diverse and often opposing roles of integrin α3β1 in cancer.

Op 2 juli promoveert Jiaqi Wang. Het Leiden University Centre for Linguistics feliciteert Jiaqi!

By growing in a soil plants change the biotic and abiotic properties of the soil in which they grow.

The thesis describes experimental steps towards reduction of friction on the macroscopic scale by scenarios of thermo- and superlubricity well-known on the nanoscale.

Innovation plays an essential role in firms' competitiveness and long-term success. It varies from different types, ranging from run-of-the-mill innovation that brings incremental changes to existing technologies to radical innovation that breaks from existing trajectories.

Nowadays, it is well known that hydrogen and helium (and small traces of lithium and beryllium) were created shortly after the Big Bang, while the heavier elements are created in the cores of stars at different evolutionary stages. When these stars explode as supernovae, they expel metals synthesised…

Om de klimaatcrisis het hoofd te bieden, kan een bepaalde nederigheid van de mens ten aanzien van de natuur van groot belang zijn. Tegelijkertijd kan nederigheid ook politieke overheersing in de hand werken. Hoe kunnen mensen zich op een bescheidener manier tot de natuur verhouden zonder hun vrijheid…

The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.

The origin and evolution of galaxies are closely linked to many different physical phenomena.

In this thesis, we present new laboratory data of interstellar dust analogues.

Jan van den Berg heeft zij proefschrift op 8 november 2018 verdedigd.

The aim of this thesis was to study phage infection in Streptomyces, focused on cell wall-deficient cells. Bacteriophages (or phages in short) attach to the cell wall of bacteria after which they replicate and lyse the host cell.

The studies described in this thesis deal with glycosidases, in particular alpha-galactosidases.

Dit artikel gaat in op de onderzoekskloof door te onderzoeken hoe deze instanties hun personeel zo kunnen inzetten dat ze maximale prestaties leveren met het personeel dat ze hebben.

Stars and planets form within cold, dense clouds of gas and dust drifting through interstellar space. Although dust makes up only a small fraction of this material, it plays a key role in shaping the chemical evolution of these environments.

This thesis focuses on amyloid proteins, a class of proteins that convert into amyloid fibrils.

Streptomyces are filamentous bacteria that produce more than two-thirds of known antibiotics.

Self-assembly offers a promising route to create complex structures and materials using simple building blocks. Through, colloidal self-assembly, we can understand the governing principles of the self-assembly process and unlock its potential in diverse applications in materials science, photonics and…

Promotor: Prof.dr. J.W.M. Frenken

This study seeks to analyse how job stress could be the result of performing administrative tasks