In previous studies at our laboratory it was demonstrated that drug exposure of HepG2 cells can lead to an altered TNFα-induced NF-κB oscillatory phenotype, concurrent with a synergistically increased sensitivity for TNFα-induced apoptosis.

Dissociative chemisorption is an important reaction step in many catalytic reactions.

De olympiades zijn jaarlijkse wedstrijden in (exacte) vakken waar alle scholieren in de bovenbouw van havo en vwo aan mee kunnen doen. De Universiteit Leiden werkt mee aan de volgende Olympiades:

Kan het gif van slangen, schorpioenen en andere dieren leiden tot nieuwe antibiotica?

Dumpy: 'Leuk dat je er bent! Ik ben Dumpy en dit is mijn pagina voor het project 'Leven in het heelal'. Op deze pagina vind je informatie over het project en links naar een encyclopedie over de planeten.

Pericytes, the mural cells of blood microvessels, are important regulators of vascular morphogenesis and function that have been postulated to mechanically control microvascular diameter through as yet unknown mechanisms.

Promotor: G.R. de Snoo, Co-promotores: M.G. Vijver, J.P.M. Vink

This thesis focuses on the synthesis, characterization and performance towards CO2 electroreduction of mono and bi-metallic particles based on p-block metals

Bekijk ons aanbod aan toetsen, van taalniveauverklaringen tot beroepskwalificaties en toelatingstoetsen.

The main focus of this thesis is the behaviour of two-dimensional materials, namely (anti)-ferromagnetic materials in the first two chapters, which show topological phases, and energetic square ice in the third and fourth chapter.

Galaxies in the Universe are distributed along the intricate framework of the Cosmic Web. Groups and clusters of galaxies comprise the densest regions in this network, and therefore, are excellent cosmic laboratories to study different aspects of galaxy evolution in extreme environments.

This thesis describes the implementation and on-sky demonstration of high-resolution integral-field spectroscopy for extreme adaptive optics systems that are used to find and characterize exoplanets.

Promotor: G. J. Kroes

One of the major limitations in culturing complex tissues or organs is the lack of vascularization in the cultured tissue. Development of a functional capillary bed could overcome this problem.

De keten die patiënten voorziet van nieuwe medicijnen, bestaat uit diverse complexe schakels: van fundamentele wetenschap, tot klinische tests, tot productie. Deze hele keten is aanwezig in Leiden. De Universiteit Leiden, het Leids Universitair Medisch Centrum (LUMC) en de bedrijven op het Leiden Bio…

Besluitvormers in de publieke sector opereren te midden van een overvloed aan informatie en onduidelijke politieke doelstellingen. Aandacht is de sine qua non van beleidsvorming: waar aandacht voor is kan geadresseerd worden in beleidsoplossingen; wat over het hoofd gezien wordt niet. Ondanks het belang…

Dit is de ervaring van drie 6-vwoklassen van het Stedelijk Gymnasium in Leiden. Zij gingen als een van de eerste klassen op zoek naar antibiotica-producerende actinomyceten uit zelf meegebrachte grondmonsters.

Faciliteiten waar LIBC leden gebruik van kunnen maken (in het Engels):

Waarin verschilt een tumorcel van een gezonde cel? Die vraag proberen onderzoekers zo precies mogelijk te beantwoorden. Sommige verschillen kunnen dienen als aangrijpingspunt voor nieuwe therapieën.

In 2011 en 2012 zijn verschillende projecten uitgevoerd gericht op de ondersteuning van de implementatie van de Kennisbasis bij de tweedegraads lerarenopleidingen Duits en Frans.

This dissertation revolves around the design and implementation of novel instrumentation and related measurement techniques, at the single molecule level, for use in biophysical research. Chapter 1 presents an introduction to the field of fluorescence-based single molecule measurements. In particular,…

Graphene nanoribbons (GNRs) are used as a current carrying substrate in investigation of current-induced forces in a low-temperature STM (chapter 2).

For optimization problems, it is often unclear how to choose the most appropriate optimization algorithm. As such, rigorous benchmarking practices are critical to ensure we can gain as much insight into the strengths and weaknesses of these types of algorithms.

The work presented in this thesis is based on ALMA surveys of protoplanetary disks in three star-forming regions: Lupus, OMC-2, and NGC 2024.

The theoretical explanation of cosmic acceleration is nowadays one of the biggest puzzles in cosmology.

In meta-analysis, heterogeneity often exists between studies. In such cases, it is essential to investigate the sources of heterogeneity and understand the relationship between effect size and study characteristics (i.e., moderators).

Taxonomy as a science has accumulated data and knowledge for more than 250 years.

Deze longitudinale studie is gericht op ontwikkelingsrisico’s bij jonge kinderen met XXY, XXX, XYY, in de leeftijd van 1 tot 6 jaar. Het doel van het onderzoek is zicht te krijgen op de factoren die bijdragen aan risico op gedragsproblemen en psychopathologie.

Promotor: Prof.dr. C.W.J. Beenakker

In this thesis, we present new laboratory data of interstellar dust analogues.

Understanding how galaxies form, interact, and evolve comes largely from comparing theory predictions with observational data. Numerical simulations of galaxies provide the most accurate approach to testing the theory, as they follow the non-linear evolution of gas and dark matter in great detail and…

We investigate the buildup of galaxies from various vantage points. The first two chapters focus on the stellar content of galaxies, especially the distribution of stellar masses at birth and potential variations therein in various galactic environments.

Promotor: V. Vitelli, Co-promotor: J. Paulose

Voordat je je inschrijft is het belangrijk dat je je huidige niveau toetst.

Promotor: W. Jaffe, Co-promotor: K. Meisenheimer

Onderzoek van de sectie Methodologie & Statistiek van het Instituut Psychologie aan de Universiteit Leiden

Promotor: Roeland M.H. Merks

Wetland plants are distinguished from plants of other terrestrial ecosystems by their adaptations to specific habitat stresses, including waterlogged and flooding and the subsequent abundance of phytotoxic compounds.

β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…

This thesis involves three topics: benchmarking discrete optimization algorithms, empirical analyses of evolutionary computation, and automatic algorithm configuration.

This thesis focuses on enhancing predictions of central nervous system drug exposure using the LeiCNS-PK3.0, a physiologically based pharmacokinetic model.

Promotor: Prof.dr. M.L. van Heck, Co-Promotor: B.P. Tighe

One of the key limitations of the direct imaging of exoplanets at small angular separations are quasi-static speckles that originate from evolving non-common path aberrations (NCPA) to which the primary adaptive optics system is inherently blind. The main focus of this thesis is the development and…

Ice, the solid state of water, plays an important role on our planet as well as the entire universe.Despite the fact that an individual water molecule has a very simple structure, its chemical bonding in the solid phase can be surprisingly complex.

This thesis focuses on developing wafer-scale two-dimensional (2D) materials by combining synthesis, transfer, characterization, and device integration of graphene, hexagonal boron nitride (h-BN), and BN-doped amorphous carbon.

De programmagroep Leer- en Gedragsproblemen in het Onderwijs doet onderzoek naar stagnaties die kunnen optreden in de cognitieve ontwikkeling.

Dit kwartet bevat in 80 vensters de essentie van de canon van de Criminologie.

Promotor: Prof.dr. K.H. Kuijken, Co-Promotor: H.Hoekstra