This Thesis describes the synthesis of D-alanylated ribitol-based wall teichoic acids from S. aureus to probe their interaction with immune-binding partners.

Discover the master program population Health Management at Leiden University and contribute to a more integrated health care system. Learn more!

Artin L-functions associated to continuous representations of the absolute Galois group G_K of a global field K capture a lot of information about G_K as well as arithmetic properties of K.

Artificial intelligence algorithms govern in subtle, yet fundamental ways, the way we live and are transforming our societies. The promise of efficient, low‐cost or ‘neutral’ solutions harnessing the potential of big data has led public bodies to adopt algorithmic systems in the provision of public…

Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar-Jagalska

The mission of our group is understanding how science communication works to improve the interaction between science and society. We believe better science communication can improve our society and engage many different groups with science, also improving science.

Promotor: M. Franx, Co-Promotor: I.F. Labbé

The main focus of the thesis is the discovery and development of novel inhibitors of bacterial metallo-β-lactamases (MBLs).

Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.

Mechanical metamaterials are man-made materials which derive their unusual properties from their structure rather than their composition.

Promotor: F.J. van Lunteren, E. Jorin

In the Schouwburgstraat, LUGO is currently redesigning the back-garden in order to increase biodiversity and make it a more beautiful space. Throughout October 2023 until March 2024, we will be making changes to the garden with our team of volunteers.

Neuraminidases are enzymes that cleave glycosidic linkages of sialic acid. These enzymes are involved in influenza infections as well as in many cellular processes in mammals and micro-organisms.

In this thesis, time-lapse fluorescent microscopy plays a pivotal role in investigating functional materials within living cells as well as the migratory behaviour of neural progenitor cells.

The studies described in this thesis deal with glycosidases, in particular alpha-galactosidases.

Binnen FSW is er een kernteam gevormd met contactpersonen binnen de instituten en op faculteitsniveau.

Evolution acts via mutations in amino acid sequences. Substitution of essential amino acids leads to a nonfunctional protein. l.

With the emergence of online social networks (OSNs), the way people create and share information has changed, which becomes faster and broader than traditional social media.

In this thesis, I study 1) metabolic alterations in tuberculosis related to wasting syndrome in human patients as well as in rodent and fish animal models. 2) effects of the mutation of the leptin gene on cachexia and diabetes in rodent and zebrafish animal models.

Binnen FSW is er een kernteam gevormd met contactpersonen binnen de instituten en op faculteitsniveau.

Discover the master program Health, Ageing and Scoiety at Leiden University and contribute to a future proof health care system. Read more.

Op 1 juni 2022 verdedigde Tom Herrenberg het proefschrift 'Prosecutorial Discretion in International Criminal Justice'. Het promotieonderzoek is begeleid door prof.dr. P.B. Cliteur en prof.dr. B.R. Rijpkema.

Zes medewerkers van de Universiteit Leiden ontvangen dit jaar de Erasmus+ International Credit Mobility-beurs voor uitwisselingsprojecten met niet-Europese partneruniversiteiten. Het totale bedrag van zo'n 357.000 euro wordt gebruikt voor de uitvoering van ongeveer 50 internationale mobiliteiten.

Van indringende documentaire tot hartverwarmende filmklassieker: vier Leidse alumni kozen hun favoriet en introduceren deze op het Leiden International Film Festival. Het zijn vrouwenrechtenverdediger Emine Kaya, correspondent Cindy Huijgen, dj Armin van Buuren en schrijver Jeroen Windmeijer.

Wat doet de Universiteit Leiden om haar gebouwen en campussen toekomstbestendig en onafhankelijk van fossiele energie te maken?

A neurocognitive investigation of the development of social performance monitoring in youth growing up in stressful versus non-stressful environments

This study has been carried out in the community of Sukamiskin, a kelurahan (‘village’) in Bandung, the Capital of West Java Province, located in the Sunda Region of Indonesia.

Op 18 september 2019 verdedigde Huw Llewellyn zijn proefschrift 'An Institutional Perspective on the United Nations Criminal Tribunals: Governance, Independence and Impartiality'. Het promotieonderzoek is begeleid door promotoren prof.dr. N.M. Blokker en prof.dr. L.J. van den Herik.

Promotores: F.H.J. Redig, W.T.F. den Hollander

The confinement of molecular catalysts in metal-organic frameworks has the potential to lead to significant improvements in selectivity, long term activity and catalyst stability.

Dankzij een nieuw medicijn hebben kankerbehandelingen in de toekomst mogelijk een stuk minder bijwerkingen. Door het medicijn te combineren met licht, doodt het alleen tumorcellen, zonder ook gezonde cellen aan te vallen. ‘We kunnen al zeggen dat het veelbelovend is’, zegt biochemicus Liyan Zhang bij…

This thesis consists of three papers that are centered around the common theme of Hausdorff uo-Lebesgue topologies and convergence structures on vector lattices and on vector lattices and vector lattice algebras of order bounded operators.

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

Promotor: G. J. Kroes

In this thesis, we aim to shed light on the diverse and often opposing roles of integrin α3β1 in cancer.

This thesis provides explicit expressions for the density functions of absolutely continuous invariant measures for general families of interval maps, that include random maps and infinite measure transformations, not necessarily number systems.

The focus of this thesis is on the technical methods which help promote the movement towards Trustworthy AI, specifically within the Inspectorate of the Netherlands.

Detecting nanoscopic objects plays an important role in nanoscience in particular, in the rapidly growing field of nanobiology. The forebear to modern super-resolution microscopy for single molecule investigation, is fluorescence microscopy.

Promotor: Prof.dr. J.N. Kok

Promotores:Th.J.C. van Berkel, M. van Eck

Dissochaeta Blume (Melastomataceae, tribe Dissochaeteae) is well-known as a scrambling plant genus found in Southeast Asia, where it is an inhabitant of the tropical rainforests or evergreen forests.

Promotor: M. Ubbink, Co-promotor: G. Siegal

Carbohydrates are present on the surface of bacteria making them suitable antigen candidates for vaccine development. This thesis deals with the synthesis of two carbohydrate-based components; the capsular polisaccharide of S. aureus type 5 and teichoic acids from staphilococci and enterococci speci…

Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.

Dissociative chemisorption is an important reaction step in many catalytic reactions.

Promotor: Prof.dr. H.V.J. Linnartz, Co-Promotores: S. Ioppolo, H.M. Cuppen

Despite being the second largest transmembrane protein family after GPCRs, the SLC superfamily has only gained significant attention in early drug development over the past decade.

Freshwater biodiversity has been threatened by eutrophication due to excessive nutrients in the environment. Releasing the freshwater species from such pressures requires efforts from industry and manufacturers to avoid emissions to vulnerable and high-risk regions.

Self-assembly offers a promising route to create complex structures and materials using simple building blocks. Through, colloidal self-assembly, we can understand the governing principles of the self-assembly process and unlock its potential in diverse applications in materials science, photonics and…

Promotor: M.T.M. Koper, Co-Promotor: L.B.F. Juurlink