Unconstrained day-to-day activities are difficult to quantify and how the corresponding movements shape the brain remain unclear. Read more

In dit artikel onderzoekt Amandine Lerusse hoe de volgorde van prestatie-informatie de prioriteringsbeslissingen van lokale politici beïnvloedt.

M. Danhof, Co-promotores: J. Freijer, A. Yassen

In this thesis unconventional tools based on fluidic interfaces were developed to study the surface and interfacial chemistry of graphene, to characterize the intrinsic properties of graphene, to disentangle the effects of substrate and of the environmental factors, and to improve handling protocols…

Glycosidases (GHs) are enzymes responsible for the degradation of carbohydrates and play many roles in human health and pathophysiology. Often, abnormal levels of glycosidase activity are markedly linked to human pathologies.

In this thesis we explore machine and deep learning approaches that address keychallenges in high dimensional problem areas and also in improving accuracy in wellknown problems. In high dimensional contexts, we have focused on computational fluid dynamics (CFD) simulations.

In today's volatile market environments, companies must be able to continuously innovate. In this context, innovation does not only refer to the development of new products or business models but often also affects the entire organization, which has to transform its structures, processes, and ways of…

Per 1 november 2018 zal professor Ewan McKendrick QC aantreden als de nieuwe hoogleraar Anglo-Amerikaans Privaatrecht en verbonden zijn aan het Instituut voor Privaatrecht van de rechtenfaculteit van de Universiteit Leiden.

Promotor: Prof.dr. A.W. van der Vaart

Carbon dioxide capture and utilization technologies are necessary to create a truly circular economy. The electrochemical reduction of carbon dioxide to formate is an appealing carbon utilization method as it can be performed at room temperature and pressure, it only requires two electrons, and it has…

Wetlands provide many ecosystem goods and services which include fish production. The sustainability of small-scale fisheries (SSF) has received considerable attention in recent years because fish is one of the major sources of animal protein to a considerable fraction of the global population which…

Modeling and analysis of cyber-physical systems are still challenging. One reason is that cyber-physical systems involve many different parts (cyber or physical), of different nature (discrete or continuous), and in constant interaction via sensing and actuating.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

In April 2022 a new monograph by Carine van Rhijn (Utrecht) will be published, entitled "Leading the Way to Heaven. Pastoral Care and Salvation in the Carolingian Period".

Promotores: A.P. IJzerman, H.W.T. van Vlijmen

Mechanical metamaterials are carefully engineered materials whose properties are controlled by their structure, not by their composition, which allows using metamaterials to study and control physical effects in detail⁠.

This thesis aims to demonstrate how the achromatic nature and design flexibility of liquid-crystal optics can be used to improve high-contrast imaging instruments to facilitate detailed exoplanet characterization.

The key characteristic of active matter is the motion of an emergent collection (such as a flock of birds), which is driven by the consumption of energy by its active components (i.e. individual birds).

Op 6 oktober 2021 heeft Simone van der Hof een lezing gegeven over age verification and age appropriate design.

Met dit onderzoek wil het directoraat-generaal politie, straffen en beschermen inzicht krijgen in de aard en zo mogelijk de omvang van de ontwikkelingen op het gebied van de pluralisering van de politiefunctie in Nederland als ondersteuning voor het toekomstige beleid ten behoeve van de politie.

You are invited to sign in for the Tabula Gratulatoria for a volume that has been composed for the occasion of Prof. Dr Marc Boone’s retirement.

Op 17 januari houdt Frits Scholten (Rijksmuseum Amsterdam) een lezing getiteld: "Private Devotion & Immersive Play - The Use of 'Spiritual Toys' in the Late Middle Ages". De lezing wordt gehouden in het kader van een Lorentz center workshop over 'Religious Imagination in the Late Medieval Low Countries…

Biological polymers, including proteins and the genome, undergo folding processes crucial for their proper functioning. Even slight changes in the folding structure of these biopolymers can have significant implications, leading to the development of various pathological conditions, such as neurodegenerative…

This thesis describes the synthesis and biochemical evaluation of a variety of cyclophellitol based activity-based probes and inhibitors targeting various endo- and exo-acting retaining glycosidases. In the last two decades a variety of probes and inhibitors for (hemi)cellulose degrading enzymes have…

Op 7 oktober 2021 was Simone van der Hof te gast bij een online talkshow in het kader van de Dutch Media Week met als thema het onderzoek waaraan zij werkt met Tony van Rooij van het Trimbos Instituut en Max Birk van de TU Eindhoven: Behavioral Design in Video Games.

Students Practicing Citizen Journalism

The invention of neural networks marks a critical milestone in the pursuit of true artificial intelligence. Despite their impressive performance on various tasks, these networks face limitations in learning efficiently as they are often trained from scratch.

Lezing

Metal-organic compounds hold great promise as photoactivated chemotherapy (PACT) agents, leveraging their unique geometric and electronic properties to achieve precise spatiotemporal control over drug activation.

Immersieve, multidisciplinaire en didactisch verantwoorde leeractiviteiten die zijn ontworpen om capaciteitsopbouw te bevorderen in verschillende spelgebaseerde formats.

Innovation plays an essential role in firms' competitiveness and long-term success. It varies from different types, ranging from run-of-the-mill innovation that brings incremental changes to existing technologies to radical innovation that breaks from existing trajectories.

This proposed research uses ego-documents from visual artists that were not intended for publication to reassess the scholarly debate on the demise of the Russian Avant-garde aesthetic in the twenties and early thirties of the 20th century.

Simone van der Hof, hoogleraar Recht en Digitale Technologie bij eLaw, is als expert toegetreden tot de EU Special Group on Code of Conduct for age-appropriate design.

This dissertation is an experimental study of laser-generated, atmospheric pressure, transient toroidal helium plasmas.

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea

Promotor: W. Jiskoot, Co-promotor: A. Hawe

Microscopic insight on lipid-based nanomedicine in vivo remains limited to the perception of the knowledge that could be obtained: if we interpret only what we see, then we only believe to know. Although believing to know encapsulates an undefined amount of uncertainty in the exploration of lipid-based…

Inverse problems are problems where we want to estimate the values of certain parameters of a system given observations of the system. Such problems occur in several areas of science and engineering. Inverse problems are often ill-posed, which means that the observations of the system do not uniquely…

This thesis describes the design and development of subunit‐selective inhibitors of particular catalytically active subunits of human constitutive proteasomes and immunoproteasomes.

This thesis considers multi-prover commitment schemes whose security is based on restrictions on the communication between the provers.

In a typical glycosylation reaction, a donor is activated to form a (variety of) electrophilic species which can react with a nucleophilic acceptor, following a reaction mechanism having both SN1 and SN2 character.

As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.

This thesis explores how electron paramagnetic resonance (EPR) spectroscopy can be used to investigate key biochemical processes.