Promotores: J. Jonkers, K.E. de Visser

In this thesis we investigate cosmology and the large scale structure of the Universe using cosmological simulations.

Promotor: P.D. Grünwald

Promotor: Prof.dr. P. Stevenhagen

The overall objectives of my thesis are to investigate the dynamics of the sorghum root microbiome and to explore the beneficial effects of the root microbiome on sorghum growth and stress tolerance.

Promotores: J.A.van Veen, P.L.G.Klinkhamer. Co-promotor: E.E.Kuramae

Pectin is a plant cell wall polysaccharide made of mainly D-galacturonic acid (GA) subunits. The potency of the filamentous fungus Aspergillus niger to naturally secrete high amounts of pectinases to degrade pectin has been utilized for the industrial production of pectinases.

This thesis applies data mining in commercial settings in the telecommunications industry.

Promotor: Johan Kuiper, Co-promotor: Saskia C.A. de Jager

Multiple stars, that is two or more stars composing a gravitationally bound system, are common in the universe.

Constraint multi-objective optimization with a limited budget for function evaluations is challenging. This thesis tackles this problem by proposing new optimization algorithms. These algorithms are applied on holistic ship design problems. This helps naval architects balance objectives like cost, efficiency,…

Cancer is considered the silent pandemic of the 21st century and the second leading cause of death worldwide.

Promotor: W. Jiskoot, Co-promotor: H.A. Every

G protein-coupled receptors (GPCRs), one of the largest families of membrane proteins, are responsive to a diverse set of physiological endogenous ligands including hormones and neurotransmitters.

Promotor: Prof.dr. J. Kuiper

Astronomical observations of cold regions in the universe show a rich inventory of ices. Part of these ices may end up on planets like our own, but in that journey they will be exposed to considerable amounts of radiation.

Promotor: Prof.dr. S.F. Portegies Zwart

This dissertation investigates the energy and material related impacts of the transition towards a low-carbon heating system in the Netherlands, in the context of its 2050 climate and circular economy policy goals.

The work done during this PhD research, aims to investigate the effect of tidal heatingin the observability of extra-solar satellites around exoplanets.

Low-mass main-sequence stars like our Sun are continuous sources of outflowing hot magnetised plasma. In the case of the Sun, this is known as the solar wind, whereas for other stars they are called stellar winds.

Complex Organic Molecules (COMs) have been detected in objects across different stages of stellar evolution.

Promotores: P. Stevenhagen, A. Enge Co-Promotor: T.C. Streng

In some condensed matter systems, such as the surface of a 3D topological insulator, the electrons are effectively massless and we must necessarily use the massless Dirac equation to describe them.

My PhD thesis investigates the ecological significance of resistance against drought-induced air bubble formation inside the water conduits of plants (embolism), and the plasticity and functional aspects of stem anatomical traits in woody and herbaceous species.

Why do black holes emit thermal radiation? And how does a closed quantum system thermalize?

Plants and soils from natural ecosystems harbor great diversity of soil microorganisms, which could potentially contribute to the sustainability of horticulture. The knowledge about using wild plant species and soil from natural ecosystem to improve the crop health will advance the application of ecological…

Promotor: R. Gill, Co-promotor: P. Massart

The demand for neodymium-iron-boron (NdFeB) magnets is rapidly growing, while the neodymium supply chain is under pressure. Recycling can alleviate these issues. This thesis investigates the potential for deploying novel magnet recycling technologies and their environmental consequences.

With the advent of multicore processors and data centers, computer hardware has become increasingly parallel, allowing one to run multiple pieces of software at the same time on different machines. Coordination of these pieces is best expressed in a coordination language as an explicit interaction protocol…

A common method to solve expensive function evaluation problem is using Bayesian Global Optimization, instead of Evolutionary Algorithms.

The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.

Promotor: Prof.dr. B.R. Katzy, Prof.dr. J. de Vries

One of the main challenges in the development of an effective anti-cancer vaccine is the generation of an adequate and directed cellular immune response.

Streptomyces are bacteria abundant in soil that participate in diverse and complex interactions. These bacteria are the main producers of the antibiotics we currently use in the clinic.

Promotor: E. F. van Dishoeck, Co-promotor: C. Walsh

The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.

My work focuses on a class of astronomical objects called protoplanetary disks.

This dissertation consists of two parts, each of which considers a different research area related to random interval maps. In the first part we are interested in random interval maps that are critically intermittent.

Statistical considerations guide the design and implementation of the experiments that scientists perform. For instance, in a clinical trial about a the efficacy of a treatment, its effect in a certain minimum amount of patients has to be observed in order to make confident assertions about the efficacy…

Op 11 november 2021 verdedigde Mariana Gkliati het proefschrift 'Systemic Accountability of the European Border and Coast Guard'. Het promotieonderzoek is begeleid door promotoren prof.dr. P. Rodrigues en prof.dr. L. Besselink (UvA).

Promotor: S.J. Edixhoven, Co-promotor: R.S. de Jong

Een elastische doek over een kom die de ruimte voorstelt, een knikker die op het oppervlak een kuiltje veroorzaakt en zo de ruimte vervormt. Eenvoudige klasexperimenten zoals deze zijn te zien in nieuwe educatieve video's van AstroEDU. In de video's leggen de Leidse astronomen Maria Cristina Fortuna…

Promotores: Prof.dr. G.A. Persoon & Prof. dr. H.H. de Iongh

Op 19 februari 2020 verdedigde Richard Jiang zijn proefschrift '‘Greening’ the WTO Ban on China’s Export Duties'. Het promotieonderzoek is begeleid door promotor prof.dr. M.C.E.J. Bronckers.

Promotor: Prof.dr. H.J.M de Groot, Co-Promotor: A. Alia

Plant architecture has distinct forms in different plant species, but also within a species the finalarchitecture of a plant is determined by its gradual development and changes therein induced by environmental conditions during the plant’s life cycle.

Het begrijpen van de wereld om ons heen hangt af van het vermogen om de wereld te ontleden in verschillende objecten en deze in hun geheugen op te slaan. Dit proces wordt gedefinieerd als object individuatie. Onderzoek wijst uit dat dit voor baby’s niet altijd gemakkelijk is.

Als mensen hebben we de neiging om bepaalde handelingen als goed of fout te beoordelen. Waar komt ons morele besef vandaan? We hebben bewijs gevonden dat baby's van slechts één jaar oud de voorkeur geven aan degenen die troosten in plaats van negeren wanneer iemand verdrietig is.

Met AI kunnen nieuwsredacties razendsnel beelden genereren — maar tegen welke prijs? Dit onderzoeksrapport opgesteld door prof. dr. Jaap de Jong, dr. Astrid Vandendaele, Maartje van der Woude en Stef Arends (Universiteit Leiden), baseert zich op 59 interviews met beeldmakers, redacteurs en experts uit…

Bevordering van duurzame fysieke activiteit door middel van het betrekken van de sociale omgeving in beweeginterventies voor diverse patiëntgroepen met cardiovasculaire aandoeningen.