Promotor: Prof.dr. G.R. de Snoo, Co-promotor: R. Heijungs

We present an extensive study of methods for exactly solving stochastic constraint (optimisation) problems (SCPs) in network analysis. These problems are prevalent in science, governance and industry.

Novel entities may pose risks to humans and the environment. The small particle size and relatively large surface area of micro- and nanoparticles (MNPs) make them capable of adsorbing other novel entities, leading to the formation of aggregated contamination.

Despite the history of studies on methanol formation from CO2, the dominant elementary reaction steps that constitute the chemical mechanism for this catalyzed process are not determined.

At the largest scales, two ingredients dictate the distribution of matter in the Universe. The first is dark matter, acting as an invisible scaffolding held together by gravitational forces.

In this thesis I highlight the applications of Oxford Nanopore Technologies (ONT) sequencing. This technique is a relatively new approach in the sequencing field, where nanopores are embedded in a membrane, DNA molecules are pulled through nanopores and an electrical current serving as the sequencing…

Promotor: Prof.dr. I.A.G. Snellen, C.U. Keller

Stochastic resetting is simple enough to be approached analytically, yet modifies stochastic processes in a non-trivial way.

Promotores: Prof.dr. G.W. Canters, Prof.dr. T.J. Aartsma

For centuries astronomers studied the Universe by collecting light. Nowadays, we are living in times of great technological advancements, which allow us to explore our Universe in a new way - though gravitational wave radiation.

Why do black holes emit thermal radiation? And how does a closed quantum system thermalize?

Promotores: Prof.dr. B.R. Katzy, Prof.dr. K. Sailer (Munich University)

Heterogeneous catalysis is one of the fundamental processes of modern life, being common in industrial refinery and hydrogen vehicles, all the way to the living cell. The dissociation of H2 on Cu(111) is an important benchmark system for studying heterogeneous catalysis, with a large and varied amount…

Natural resources often stretch across borders that separate modern nation states. This can create conflict and limit opportunities for regulated consumption of their goods and services, but also provide opportunities for joint multinational efforts that exceed single country capabilities.

The ultimate goal of cosmologists is to find a cosmological model able to explain the current observational data.

Promotor: R. Cramer

Promotor: Thomas Hankemeier, Co-promotores: Heiko van der Linden, Paul Vulto

My work focuses on a class of astronomical objects called protoplanetary disks.

Dit onderzoek gaat over het gebruik en de interpretatie van hoeveelheidsuitdrukking in verschillende talen, met name in relatie tot telbaarheid.

Dit project gaat over (1) hoe de strategieën die gebruikt worden om epistemiciteit uit te drukken verschillen in hun interpretatie en gebruik; (2) welke strategieën kunnen gecombineerd worden en tot welke effecten dit leidt; (3) wat de uitdrukking van (verschillende aspecten van) epistemiciteit ons…

Dit onderzoek gaat over hoe automatische gebarentaalherkenningstechnologie verder ontwikkeld kan worden om statische beelden en tekstuele beschrijvingen van gebaren te analyseren.

The way organisms develop from the initial single-cellular state to a complex final assembly like the human body, and how the final body is maintained throughout life, is one of the greatest mysteries and it’s understanding one of the biggest scientific challenges.

This thesis explores Breaking of Ensemble Equivalence (BEE) in random graph models by examining the spectral properties of adjacency matrices. The goal is to identify spectral characteristics that differentiate random graph ensembles, enhancing the understanding of complex network structures and beh…

Over the last three decades, the discovery of exoplanets has revealed the boundless variety of worlds beyond our own Solar System⁠. Majority of planetary systems contain short-period planets that are larger than Earth but smaller than Neptune⁠.

This thesis investigates Open-world Continual Learning (OWCL), a learning paradigm designed for intelligent systems operating in non-stationary environments with persistent exposure to unknown data.

Kijk regelmatig op deze pagina voor meer informatie over het vergroten van de biodiversiteit aan de Universiteit Leiden.

Wetenschappers hebben een neutrino ontdekt met de hoogste energie ooit gemeten. Leidse natuurkundigen Maarten de Jong en Dorothea Samtleben werkten mee aan dit project, waarover afgelopen week te lezen was in alle kranten en op alle online media.

At the moment, over 350.000 chemicals are registered worldwide for production and use. Their application, however, may harm human health and the environment.

Promotor: P.D. Grünwald

This thesis is about the study of hydrocarbons via infrared spectroscopy.

Promotor: S.M. Verduyn Lunel

Promotor: G.P. van Wezel

Curved single crystals provide variable, but well-defined surface structures.

Promotor: Carel J. ten Cate, Co-Promotor: Hans W. Slabbekoorn

Ferritin is a spherical metalloprotein, capable of storing and releasing iron in a controllable way. It is composed of a protein shell of about 12 nm and within its cavity, iron is stored in a mineral form.

Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.

Promotores: Wim Jiskoot; Ferry Ossendorp

Promotor: Prof.dr. K.J. Batenburg

Promotor: Prof.dr. M.K. Richardson

Promotor: C.A.J. Knibbe, Co-promotor: J.J. Boelens, R.G.M. Bredius

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

Promotor: J.N. Kok, Co-promotor: M.S. Lew

The first steps are made in personalised cancer vaccination strategies, which aim to induce a more specific immune response with fewer side effects. The activation of cytotoxic T cells is crucial for an effective immune response.

In this work, I explore the creation of new methods that optimize simulations of the gravitational N-body problem. Specifically, I take advantage of the recent popularity of Machine Learning methods to find tools that can suit this problem.

Promotor: Ed F. Deprettere, Co-promotor: Todor P. Stefanov

There are many interpretations of quantum mechanics, and ultimately experiments are needed to verify or falsify these interpretations.

The research aims to explore the evolutionary adaptability of enzymes and the impact of temperature on protein evolution pathways, using M. tuberculosis β-lactamase BlaC as the object of study. Enzymes inherently embody a delicate balance between activity and stability, and the acquisition of new enzymatic…

The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.

Principles of Environmental Sciences provides a comprehensive picture of the principles, concepts and methods that are applicable to problems originating from the interaction between the living and non-living environment and mankind. Both the analysis of such problems and the way solutions to environmental…