Promotor: Prof.dr. J.N. Kok, Co-promotor: F.J. Verbeek

Cardiovascular diseases are still a major concern for the global health.

Automated Machine Learning (AutoML) is widely used to automatically build a suitable practical Machine Learning (ML) model for an arbitrary real-world problem, reducing the effort of practitioners in the ML development cycle for real-world applications. Optimization is a key part of a typical AutoML…

Promotor: B. van de Water, Co-promotor: E.H.J. Danen

This thesis introduces the concept of

Metabolomics has the potential to play a pivotal role in understanding disease onset and progression, and ultimately personalized treatments. One of its major challenges is its large-scale implementation, which is necessary to deal with the high variability of the metabolome. In this work we have developed…

Internationale wetenschappelijke consortia zijn steeds belangrijker binnen de wetenschap. Ze staan tegenwoordig vaak centraal bij de aanpak van mondiale vraagstukken op het gebied van gezondheid, milieu en schone energie. Ze kennen echter ook unieke uitdagingen. Om die in kaart te brengen, ontving hoogleraar…

Machine Learning is becoming a more and more substantial technology for industry.

Healthcare Information Systems (HIS) are essential for modern healthcare delivery, yet their development faces significant challenges including heterogeneous data formats, regulatory compliance, and the growing demand for AI-driven decision support.

Je kiest voor de studie Bio-Farmaceutische Wetenschappen wanneer je sterk geïnteresseerd bent in de ontwikkeling van en het onderzoek naar de werking van geneesmiddelen.

De Universiteit Leiden wil haar studenten toerusten voor de wereld van morgen. In ons onderwijs stimuleren we internationale kennis, mondiaal bewustzijn en interculturele vaardigheden.

This thesis focuses on addressing four research problems in designing embedded streaming systems.

Kinderen zijn van nature kleine wetenschappers. De beste manier om ze kennis te laten maken met wetenschap is door ze aan het werk te zetten en ze daadwerkelijk wetenschappelijk onderzoek te laten doen.

Hermen Overkleeft en zijn collega’s Gideon Davies (Universiteit van York) en Carme Rovira (Universiteit van Barcelona) ontvangen een ERC Synergy Grant ter waarde van 9,1 miljoen euro. Samen zullen zij het Carbocentre Synergy-team vormen voor onderzoek naar enzymen die werken op glycans: complexe koolhydraten.…

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: R.G. Boot

Als mensen met elkaar praten wisselen sprekers elkaar soepel af, met gemiddeld zeer korte tussenliggende pauzes. Gesprekspartners moeten daarom steeds vooruit plannen wat ze willen zeggen en wanneer ze de beurt kunnen overnemen. Spraakmelodie speelt hier hoogstwaarschijnlijk een rol bij, maar onduidelijk…

Software and AI in Business (S&B) verbindt de domeinen wetenschap, bedrijfsleven en beleid. Wetenschappelijk onderzoek waar we ons in Leiden op richten, bijvoorbeeld op het gebied van kunstmatige intelligentie, belooft onze samenlevingen ten goede te komen. Het vertalen van wetenschap naar positieve…

Parkinson's disease is the second most common neurodegenerative disease in the world. One of its symptoms is the loss of dopaminergic neurons in the substantia nigra pars compacta.

In this Yearbook you will find some fascinating examples of what was done in 2021, not only by ourselves, but also by our international colleagues.

In this dissertation iron-based homogeneous catalysts were synthesized, characterized and investigated for water oxidation activity.

Antimicrobial drugs constitute a fundamental part of modern medicine. The global rise in antimicrobial resistance poses a major threat to global health.

In this thesis unconventional tools based on fluidic interfaces were developed to study the surface and interfacial chemistry of graphene, to characterize the intrinsic properties of graphene, to disentangle the effects of substrate and of the environmental factors, and to improve handling protocols…

Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…

The availability of indicators based on social media has opened the possibility to track the online interactions between social media users and scholarly entities.

Growth hormone profiles are pulsatile and highly variable between individuals, limiting the implementation of mathemathical models to quantify an individual's secretion.

Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.

In this work, we attempt to answer the question:

A New Technology-Based Firm (NTBF) is a significant enabler of job creation and a driver of the economy through stimulating innovation.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

In this dissertation, the synthesis and characterization of a series of iron complexes based on different ligand platforms are described.

Promotor: Prof.dr. T. Hankemeier

This dissertation investigates the energy and material related impacts of the transition towards a low-carbon heating system in the Netherlands, in the context of its 2050 climate and circular economy policy goals.

The redox-conversion reaction of metal-disulfide and metal-thiolate complexes are important, as they may shed light on electron-transfer reactions that often occur in Nature.

We explored how to morphologically classify well-resolved jetted radio-loud active galactic nuclei (RLAGN) in the LOw Frequency Array (LOFAR) Two-metre Sky Survey (LoTSS) using machine learning.

Promotor: Prof.dr. B.R. Katzy, Prof.dr. J. de Vries

Stars like the sun are born in large molecular clouds existing from gas and dust. During the formation process, the chemical composition of the material can be altered drastically by the changing physical conditions.

Due to their central physiological roles in living organisms, retaining beta-glycosidases have been the subject of tremendous research efforts to examine their structure/function relation using numerous biophysical and biochemical approaches.

The aim of this thesis is to expedite and ensure the systematic accuracy of clearance scaling from adults to paediatric patients, with a special focus on drugs undergoing hepatic metabolism.

Promotores: G.R. de Snoo, W.T. de Groot, Co-promotor: C.J.M. Musters

Modeling and analysis of cyber-physical systems are still challenging. One reason is that cyber-physical systems involve many different parts (cyber or physical), of different nature (discrete or continuous), and in constant interaction via sensing and actuating.

The research in this thesis is focused on tomographic reconstruction based on two imaging modalities in electron microscopy.

Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik

Afgestudeerden van de masterspecialisatie Onderwijs en Opvoeding in een Digitale Wereld aan de Universiteit Leiden zijn goed voorbereid op uiteenlopende functies. Zij kunnen bijvoorbeeld kindertherapeuten adviseren over e-healthtoepassingen, scholen begeleiden bij het gebruik van digitale middelen en…

Promotor: Prof.dr. P.C. van Welzen

Vijfhonderd jaar Charles de l'Écluse

Vijfhonderd jaar Charles de l'Écluse