The work in this thesis has been focused on two subjects. The first is the assembly of alginate oligosaccharides and the generation of building blocks for the enzymatic synthesis of alginate, and the second is the total synthesis of large fragments of the zwitterionic SP1 polysaccharide.

Promotor: Prof.dr. A.G.G.M. Tielens, Prof.dr. C. Dominik (UvA)

The parabolic Anderson model (PAM), which is the Cauchy problem for the heat equation with random potential. The PAM is a mathematical model that describes how mass (i.e. matter or energy) flows in a medium in the presence of a field of sources and sinks.

Molecular complexes can be used as electrocatalysts for oxygen reduction, water oxidation, and/or hydrogen peroxide production.

This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion.

With an emphasis on developing novel miktoarm star polymers termed PeptoMiktoStars, this thesis leverages asymmetric polymeric polypept(o)ide frameworks to advance their effectiveness in delivering hydrophobic drugs and nucleic acids.

Despite being the second largest transmembrane protein family after GPCRs, the SLC superfamily has only gained significant attention in early drug development over the past decade.

Software development is a complex process. It is important that software products become stable and maintainable assets.

Pericytes, the mural cells of blood microvessels, are important regulators of vascular morphogenesis and function that have been postulated to mechanically control microvascular diameter through as yet unknown mechanisms.

In this Thesis, novel charge induction mechanisms of ionic liquids are treated, tested and experimented on complex oxides, in particular cuprates.

A structural investigation of coiled coil peptides used as membrane fusogens, mimicing naturally occuring coiled-coil fusion proteins. Synthetic modifications have been made to alter lipid attachment, secondary structure and to insert photoactive azobenzene moieties for active control over coiled coil…

Soil biodiversity is of great importance for the maintenance of multifunctionality in terrestrial ecosystems.

The focus of this thesis is on the technical methods which help promote the movement towards Trustworthy AI, specifically within the Inspectorate of the Netherlands.

The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.

This thesis describes the implementation and on-sky demonstration of high-resolution integral-field spectroscopy for extreme adaptive optics systems that are used to find and characterize exoplanets.

When a star is born in our Galaxy, it is quite likely that it has formed within a massive cluster, which hosts numerous high-mass stars bathing their lower mass neighbours in UV radiation.

Zelfredzaamheid en sociale bescherming over de levenscyclus

Exoplanets close in to their host star receive high levels of extreme ultraviolet (EUV) irradiation, capable of heating and ultimately driving the hydrodynamic escape of their atmospheres.

In this thesis, we have used numerical approaches to study the effects of translational symmetry breaking on strange metallic systems as realised by the holographic duality⁠.

In dit interdisciplinaire onderzoeksprogramma werken onderzoekers uit vijf verschillende disciplines met elkaar samen. Zij stellen zich hieronder (in het Engels) aan u voor.

Onderzoekers van de afdelingen Economie en Sociaal Recht van de Faculteit der Rechtsgeleerdheid ontvangen een Netspar Topicality Grant voor hun gezamenlijke onderzoeksvoorstel 'De pensioen gendergap in Nederland'.

Studying the impact of urbanisation on the respiratory health of past Dutch populations (1200-1850 CE).

Van onderwijs tot een verrijkende ervaring

Dit waren de hoofdsprekers en sessieleiders op De Kennisboomgaard 2025:

De onderzoekers van het departement ‘World Archaeology’ van de Faculteit Archeologie richten zich in hun onderzoek op verschillende periodes en regio’s: van de oorsprong van de mens tot aan de Middeleeuwen en de moderne tijd, en van Azië tot Zuid-Amerika.

Welkom bij het project Fair Educational Assessment in the Age of AI (FAIR-ASSESS)!

Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. M. Danhof, Prof.dr. K. Allegaert (Leuven)

The research described in this thesis shows that hypercholesterolemia, a well-established risk factor for atherosclerosis, can impact skin lipid pool and barrier function already at young age. In the field of atherosclerosis, we showed that the small peptide Lyp-1 can be used as a targeting molecule…

M. Danhof, Co-promotores: J. Freijer, A. Yassen

Growth and development affect the metabolism of drugs administered to neonates, infants, and children.

Promotor: I. A. G. Snellen, Co-promotor: M. A. Kenworthy

Prematurely born neonates require, amongst others, pharmaceutical therapy. Dosing guidelines for these therapies are often based on data from term born neonates or older infants, while these are not necessarily similar to prematurely born neonates.

Promotor: R. Verpoorte, Co-promotores: Y.H.Choi, N.R. Mustafa

Promotores: C.A.J. Knibbe; J.N. van den Anker, Co-promotores: H.P.A. van Dongen; B. van Ramshorst

Het kwantificeren van lichamelijke activiteit (met behulp van versnellingsmeters) en het combineren van de frequentie en intensiteit van activiteiten met gezondheidsgegevens (hersen-MRI, traditionele klinische parameters en metabolomics) is van het grootste belang om mobiliteit en gezondheid bij oudere…

Promotores: P.G.L. Klinkhamer, P.M. Brakefield, Co-Promotor: M. Bruinsma

Lezing

This thesis aims to develop model-based approaches to optimize drug dosing in patients with overweight and (morbid) obesity.

Students Practicing Citizen Journalism

Computational thinking, programming, and algorithms form the basic of many of the things that are shaping our world, the way we work, interact, organize ourselves, and even spend our free time with social networks, streaming media, and games. And this transformation is far from being complete, it is…

Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.

In this thesis,

Promotor: G.A. van der Marel, Co-promotor: D.C. Codée