The endocannabinoid receptors CB1R and CB2R are involved in a plethora of processes, and consequently are involved in many pathological conditions. Their wide distribution makes the CBRs both an interesting therapeutic target and hard to study.

Op 1 april 2020 verdedigde Marc Broekema zijn proefschrift 'Cognitive Bias in the Judgment of Business Valuations and Valuators'. Het promotieonderzoek is begeleid door promotor prof. dr. J.I. van der Rest.

In this thesis we investigate cosmology and the large scale structure of the Universe using cosmological simulations.

In a typical glycosylation reaction, a donor is activated to form a (variety of) electrophilic species which can react with a nucleophilic acceptor, following a reaction mechanism having both SN1 and SN2 character.

Of all the mass in our Universe, 80% is thought to consist of a hypothetical and invisible substance called dark matter (DM).

Balsaminaceae is a diverse plant family characterized by a huge floral morphological diversity.

This thesis describes the use of a combined approach of computational and experimental techniques to gain novel insights to understand the glycosylation reaction and its reactive intermediates.

Promotor: J.N. Kok, Co-promotor: C.M. Soares, A.J. Knobbe

This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.

A century ago, it was unclear whether the stars in the sky were clustered in groups, or widely spread in the universe.

Obesity may alter how a person absorbs, distributes, metabolizes or excretes medication. This thesis describes how obesity affects drug levels in the blood for antimicrobial agents, such as ciprofloxacin and fluconazole.

We explored the Universe using weak gravitational lensing, a phenomenon that occurs when light from distant galaxies is bent by the gravitational fields of closer cosmic objects, much like how a lens distorts light.

Taking as a point of departure the Italian American community in Boston and its process of collective remembrance surrounding Saint Anthony’s Feast, we addressing the limits and potential of montage.

De Faculty of Governance and Global Affairs

Promotor: J.N. Kok, P.E. Slagboom Co-promotor: J.F.J. Laros

Glycosidases (GHs) are enzymes responsible for the degradation of carbohydrates and play many roles in human health and pathophysiology. Often, abnormal levels of glycosidase activity are markedly linked to human pathologies.

Promotor: Prof.dr. A. Achucarro

We explored how to morphologically classify well-resolved jetted radio-loud active galactic nuclei (RLAGN) in the LOw Frequency Array (LOFAR) Two-metre Sky Survey (LoTSS) using machine learning.

Metals surfaces form a group of effective catalysts for the reaction of small molecules such as hydrogen (H2).

The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.

A key step in the synthesis of oligosaccharides and glycoconjugates is the formation of the glycosidic bond.

Anthropogenic noise negatively affects wildlife in a wide range of taxonomic groups.

Promotor: Prof.dr. H.J.A. Rottgering

Statistical considerations guide the design and implementation of the experiments that scientists perform. For instance, in a clinical trial about a the efficacy of a treatment, its effect in a certain minimum amount of patients has to be observed in order to make confident assertions about the efficacy…

This dissertation advances automated negotiation by developing agents that can learn and adapt across diverse negotiation settings through three increasingly sophisticated approaches: automated algorithm configuration, portfolio-based strategy selection, and end-to-end reinforcement learning with graph…

Promotor: S.J. Edixhoven, Co-promotor: R.S. de Jong

Environmental challenges such as plastic pollution and biodiversity loss require extensive monitoring. Citizen science, in which members of the public participate in scientific research, has therefore become an important approach in environmental science.

Atherosclerosis is a progressive disease resulting in the formation of an arterial plaque. Despite lipid lowering, recurrent cardiovascular events remain a risk. While atherosclerosis is primarily lipid-driven, the immune system plays a critical role in the pathophysiology.

Het onderzoeken van medische experimenten op mensen in de koloniale periode in Zuidoost-Azië.

Breast cancer (BC) is a clinically and biologically heterogeneous disease.

Effective policy-making requires understanding what truly causes a problem. Only then can policymakers develop targeted interventions that achieve desired outcomes.

Den Haag is, naast Leiden, de tweede moederstad van de Universiteit Leiden.

Hoe communiceert de Chinese overheid naar haar burgers? Yuxi Nie promoveerde op haar proefschrift over de communicatiestrategieën van het Chinese staatspersbureau Xinhua. Ze ontdekte dat Xinhua op verschillende manieren communiceerde op social media die afhankelijk was van de doelgroep.