Supervisor: S.F. Portegies Zwart Co-Supervisor: A.G.A. Brown

IoT technology poses serval opportunities to supply chains. This thesis employs grey correlation and forecasting models, system dynamics, agent-based modeling, and ex-ante LCA to investigate and quantify the opportunities and risks of IoT-enabled sustainable supply chain operations from both industrial…

Op 3 en 4 november 2022 organiseerde Melanie Fink een workshop voor de auteurs van de samengestelde uitgave ‘Access to Justice and the EU’s Remedies System’. Het boek zal naar verwachting begin 2024 verschijnen bij Cambridge University Press.

This thesis focuses on the application of lipid-based nanomedicine in drug delivery, including small molecular antitumor drugs and biomacromolecules including mRNA, and evaluates their biological performance.

Promotor: W.Th.F. den Hollander

Promotie

Glycoconjugate vaccines are composed of microbial poly- or oligosaccharides covalently linked to a carrier protein.

Toll-like receptors (TLRs) are central components of the innate immune system, functioning as pattern recognition receptors that detect microbial- and damage-associated molecular patterns and initiate antimicrobial and inflammatory responses.

Promotor: Prof.dr. G.A. van der Marel, Co-Promotor: J.D.C. Codée

Promotors: Prof.dr. J. Zaanen, Prof.dr.ir. H. Hilgenkamp

Promotor: S.J. Edixhoven, Co-promotor: K.J. Batenburg

Promotor: Prof.dr. J.N. Kok, Co-promotor: F.J. Verbeek

Promotor: Prof.dr. G.R. de Snoo, Prof.dr. G.A. Persoon, Co-promotor: H.H. de Iongh

Promotor: S.M. Verduyn Lunel, Co-promotor: O. van Gaans

Promotor: M. Danhof, Co-promotor: E.C.M. de Lange

Promotie

Het recht van de Europese Unie beïnvloedt direct en indirect de reikwijdte van strafrechtelijke aansprakelijkheid in Nederland. Die beïnvloeding heeft betekenis voor het materieelrechtelijk legaliteitsbeginsel.

This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.

The main research question of this thesis was: Can nitrogen cycling on dairy farms on peat soil in the Dutch Green Heart area be improved by adapting management to the nitrogen supply from soil and by using other grassland species and crops without affecting milk production?

The power of personalized nutrition lies in being able to conduct clinical research on healthy people while capturing metabolic markers sensitive to the impact of environmental and metabolic stressors (e.g. diet, changing sex hormones and the menstrual cycle).

Materials with strongly correlated electrons show some of the most mysterious and exotic phases of quantum matter, such as unconventional superconductivity, quantum criticality and strange metal phase.

This thesis describes the Multi-site All-Sky CAmeRA (MASCARA), which consists of two small robotic telescope designed to detect exoplanets around the brightest stars in the sky.

Promotor: S.M. Verduyn Lunel, Co-Promotores: S.C.Hille, O.W. van Gaans

The research described in this Thesis was aimed at designing and synthesizing nature-inspired compounds as part of TB vaccine discovery.

Carbohydrates are present on the surface of bacteria making them suitable antigen candidates for vaccine development. This thesis deals with the synthesis of two carbohydrate-based components; the capsular polisaccharide of S. aureus type 5 and teichoic acids from staphilococci and enterococci speci…

The inverse electron demand Diels-Alder (IEDDA) pyridazine elimination emerged in 2013 as a new bioorthogonal reaction and constitutes a prime example of what is now known as dissociative bioorthogonal chemistry. The research described in this Thesis aims to develop synthetic strategies which enable…

Promotie

Promotie

Promotor: Prof.dr. H.S. Overkleeft

De astronomie begon met het bestuderen van het licht van de sterren. Deze sterren worden geboren in uitgestrekte wolken van gas en stof.

De onderzoeksgroep Digital Archaeology beheert twee computerlaboratoria voor verschillende doeleinden: een onderwijslab en een onderzoekslab.

In this work, I explore the creation of new methods that optimize simulations of the gravitational N-body problem. Specifically, I take advantage of the recent popularity of Machine Learning methods to find tools that can suit this problem.

One of the effects of climate change is the phenomenon of desertification, a process that occurs in semi-arid and arid areas and causes land degradation as well as vegetation loss. Due to the lack of resources, vegetation self-organizes to sustain itself by forming large-scale spatial patterns.

Promotor: Prof.dr.ir. E. Deprettere

The type-IV secretion system (T4SS) is a machinery able to transfer DNA and proteins between bacteria and in certain cases also to eukaryotic cells.

In this dissertation, matching, entropy, holes and expansions come together. The first chapter is an introduction to ergodic theory and dynamical systems.

Het belangrijkste doel is het onderzoeken van de mogelijkheid om het lichaam te leren een soortgelijke fysiologische (autonome, neuro-endocriene of immuunsysteem) en fysieke (b.v. desensibilisatie van hardnekkige lichamelijke symptomen) reactie te laten vertonen op placebomedicatie als op actieve medicatie…

We consider the propagation of electrical signals through nerve fibres.

De incubatietijd (van infectie tot de eerste symptomen) en latente periode (van infectie tot de start van besmettelijkheid) zijn cruciaal voor het informeren van controle maatregelen aan het begin van een infectieziektenuitbraak. Een voorbeeld is de duur van quarantaine voor potentieel geïnfecteerden,…

In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.

Promotores: Wim Jiskoot; Ferry Ossendorp

Glucocorticoids are potent anti-inflammatory drugs widely used clinically to treat various inflammatory and immune conditions. However, two main clinical problems limit their use. GCs trigger severe side effects and they induce acquired glucocorticoid resistance, especially during chronic systemic treatment…

This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.

Healthy aging is one of the prime goals in today's society and atherosclerosis is among the greatest causes of morbidity in elderly. Cardiovascular disease patients receiving treatment are often of advanced aged and have an aged immune system, which limits translating experimental findings to the pa…

This dissertation explores new chemical strategies for the synthesis of self-adjuvanting peptide conjugates and immunomodulatory ligands aimed at targeted activation of the immune system.