This study attempts to understand how indigenous community institutions pose an important role in sustainable community-based development, including the integration between local culture and development.

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

The role of material production as a driver of environmental impacts is increasing, which calls for a better understanding of global material flows. This thesis explores the role of in-use stocks of products, buildings and infrastructure as a key driver of global material demand and discusses the implications…

The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.

Promotor: Prof.dr. J. den Hertog

Promotores: Prof.dr. J. Kuiper, Prof.dr. P.H.A. Quax, Co-promotor: I. Bot

Promotores: Prof.dr. H. van Veen & Prof.dr. W. de Boer (Wageningen University)

Promotor: J. Zaanen, Co-Promotor: V. Juricic

Promotor: Prof.dr. T. Schmidt

The aromatic infrared bands (AIBs) seen throughout the interstellar medium (ISM) are generally thought to be carried by polycyclic aromatic hydrocarbons (PAHs) and their nitrogen analogues (PANHs).

Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…

Fungal food spoilage often starts with a contamination with spores. Experimental data strongly indicate the existence of subpopulations of spores with different levels of resistance to preservation methods.

G protein-coupled receptors (GPCRs), one of the largest families of membrane proteins, are responsive to a diverse set of physiological endogenous ligands including hormones and neurotransmitters.

Promotor: J.A. Bouwstra Co-promotor: A. El Ghalbzouri

Marine sponges are important members of reef ecosystems, as they play ecological roles that are essential for the health of the reef.

This thesis describes the genetic and prokaryotic diversity of giant barrel sponges.

Promotor: B.van de Water, Co-promotor: L.S.Price

The soil-dwelling, filamentous bacteria of the genus Streptomyces are renowned for their production of useful secondary metabolites including antibiotics. The work described in this thesis provides new insights on the role and regulation of antibiotic production and resistance in these bacteria.

Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

Plants produce an astonishing variety of secondary metabolites (SMs) which are thought to play vital roles in the fitness of plants through ecological interactions.

Pancreatic ductal adenocarcinoma (PDAC) is among the cancers with the highest mortality rate, despite a relatively low incidence.

This joint Master with the Autonomous University of Barcelona will the equip you with the necessary competences to play a key role in the emerging field of transfusion medicine. The programme includes both transfusion of blood components and hematopoietic transplants, cellular and tissue therapy, and…

A convolutional neural network (CNN) is a biologically inspired algorithm, highly capable at processing images and videos.

This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion.

Promotor: Prof.dr. J.P. Abrahams

Promotor: J.M. Memelink

Promotie

The research group Science Communication and Society aims to understand how science communication works to improve the interaction between science and society. Central themes are ‘Bridging the gap between experts and the general public’ and ‘Evaluating Science Communication’.

Voordrachten in het kader van het onderzoeksproject Zelfredzaamheid en sociale bescherming over de levenscyclus (aug. 2017 – dec. 2023).

This course explores international arbitration as one of the most common methods of international dispute settlement. You will gain an in-depth understanding of international arbitration through the analysis of its role as a mechanism of dispute settlement, its institutions, the fields of law it is…

This course explains the functions of each international court and tribunal in The Hague. On the basis of cases and interviews with judges and lawyers, this course explores the role of these courts and tribunals and their potential to contribute to global justice.

Multicellular giant algae Chara species have been widely used in physiological studies for decades.

In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.

Hoewel er onder de elite en het publiek algemene consensus bestaat over de noodzaak van klimaatactie, is de bereidheid van het publiek om voor dergelijke inspanningen te betalen veel lager.

Promotor: A.P. IJzerman

Promotores: H.S. Overkleeft; G.A. van der Marel Co-Promotor: B.I. Florea

Promotor: A.P. IJzerman

As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.

The soil ecosystem consists of the largest reservoir of biodiversity on Earth.

Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.

Mechanical metamaterials are man-made materials which derive their unusual properties from their structure rather than their composition.

In this research I assess the impact of the recently discovered gas reserves south off Cyprus on the escalation of the Cyprus conflict.

The rapid expansion of research on human gut microbiome in recent decades has highlighted its role in human metabolism, immune regulation, and behavior.

Op 16 mei presenteren drie onderzoekers van de Universiteit Leiden hun bevindingen over de democratische gevolgen van decentralisatie tijdens een workshop in Leiden. Hun onderzoeksproject, Downsize My Democracy?, laat zien dat decentralisatie niet automatisch leidt tot een sterkere democratie. Integendeel,…

Artikel: “The paradox of being on the glass cliff: why do women accept risky leadership positions?”

Onze promovenda Maral Darouei heeft in samenwerking met haar dagelijkse begeleider Helen Pluut een artikel gepubliceerd in het tijdschrift Career Development International (5-year IF = 2.704). Het paper is getiteld “The paradox of being on the glass cliff: Why do women accept risky leadership positions”.…

Promotores: Prof.dr. J. Schaye & Prof.dr. C. Steidel (California Institute of Technology)

M.T.M. Koper, Co-promotor: D.G.H. Hetterscheid

In this thesis, time-lapse fluorescent microscopy plays a pivotal role in investigating functional materials within living cells as well as the migratory behaviour of neural progenitor cells.