The haplolepideous mosses (Dicranidae) comprise about 4000 species distributed over a wide range of habitats, with great gametophytic and sporophytic morphological variation. Their monophyly is well supported by the results of several molecular phylogenetic studies, which shed light on their relationships…

Kinase inhibitors are key therapeutic agents, particularly in oncology, yet their clinical efficacy is often hampered by off-target effects and limited understanding of their cellular target profiles.

Klinische psychologie richt zich vooral op de toepassing van wetenschappelijke psychologische kennis op assessment, preventie en behandeling van psychopathologie.

According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).

Promotor: G.P. van Wezel, Co-Promotor: E. Vijgenboom

Streptomyces bacteria are a valuable source of natural products, many of which are used in the clinic or in biotechnology.

Waarom zijn transnationale en interculturele agenten zoals Henrich Carloff en Willem Leyel belangrijk voor de studie van de vroegmoderne expansie?

Epithelial-mesenchymal plasticity (EMP) and tumor cell migration play an important role in cancer progression, and an improved understanding of the mechanisms underlying these concepts is essential for developing new targeted approaches.

Promotor: J.N. Kok, Co-Promotor: A.J. Knobbe

Het VVI heeft als doel bij te dragen aan de sociaal-wetenschappelijke kennisvorming over de interactie tussen recht, bestuur en samenleving. Het VVI-onderzoek richt zich in het bijzonder op het ontstaan en functioneren van juridische instituties. Daarbij kijken de onderzoekers zowel naar de perspectieven…

Promotores: F.H. van Lunteren, F.P. Israel

This thesis addresses the chemical processes that determine the compositions of giant planet atmospheres.

At the largest scales, two ingredients dictate the distribution of matter in the Universe. The first is dark matter, acting as an invisible scaffolding held together by gravitational forces.

Promotor: Prof.dr. E. Deprettere

There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.

Promotor: Prof.dr. T. Schmidt

Despite being the object of intense study, embryonic development has been difficult to model due to a number of reasons. First, complex tissues can be comprised of many cell types, of which we probably only know a subset.

Promotor: W.Th.F. den Hollander Co-Promotor: F.M. Spieksma

Inspired by natural photosynthesis, perovskite-based photoelectrochemical (PEC) systems are being developed for artificial photosynthesis, aiming to enhance solar-to-hydrogen conversion for green energy.

Parkinson's disease is the second most common neurodegenerative disease in the world. One of its symptoms is the loss of dopaminergic neurons in the substantia nigra pars compacta.

Enzymes are innately sensitive to changes in the amino acid sequence, which largely constrains their evolutionary potential, i.e., evolvability. This evolutionary burden can be alleviated in the presence of stabilizing mutations, which increase the buffering capacity of enzymes to tolerate mutations…

Bij uitgeverij Hart uit Oxford verscheen het eerste deel van een (Engelstalige) reeks boeken onder de titel ‘Restatement of Labour Law in Europe’. Dit deel heeft betrekking op de vraag welke werknemer door het arbeidsrecht wordt beschermd (‘The concept of employee’).

Promotor: A. Kros

Onderzoek aan LUC past binnen het algemene kader van de wereldwijde uitdagingen die centraal staan in ons onderwijsprogramma. Het richt zich op belangrijke maatschappelijke vraagstukken, waaronder Vrede & Recht, Diversiteit, Welvaart en Duurzaamheid.

Breast cancer is the most common cancer in women worldwide. Metastasis, the process by which cancer cells spread to other parts of the body, makes treatments less effective. It is important to unravel the mechanism of metastasis.

We explored how to morphologically classify well-resolved jetted radio-loud active galactic nuclei (RLAGN) in the LOw Frequency Array (LOFAR) Two-metre Sky Survey (LoTSS) using machine learning.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

In multi/many-core System-on-Chips (SoCs), the performance is almost linearly scaling with the number of processing elements.

Promotor: E. F. van Dishoeck, Co-promotor: C. Walsh

The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.

This thesis tackles the difficulty of predicting the liver’s clinical response to novel therapies, a challenge arising from interspecies differences and limitations of existing in vitro models.

Lezing

This thesis explores Breaking of Ensemble Equivalence (BEE) in random graph models by examining the spectral properties of adjacency matrices. The goal is to identify spectral characteristics that differentiate random graph ensembles, enhancing the understanding of complex network structures and beh…

The global transition toward low-carbon energy systems and the rapid expansion of digital technologies, including artificial intelligence, are reshaping how modern societies produce, move, and process energy and information.

Studium Generale organiseert academische activiteiten, zoals lezingen, symposia, theatervoorstellingen, filmvertoningen en debatten voor een breed publiek. Het programma van Studium Generale wil vragen stellen en verdieping bieden. Iedereen is welkom, zowel studenten, medewerkers als mensen van buiten…

The way organisms develop from the initial single-cellular state to a complex final assembly like the human body, and how the final body is maintained throughout life, is one of the greatest mysteries and it’s understanding one of the biggest scientific challenges.

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Decarbonizing the building stock is critical for realizing the climate-neutral target for the Netherlands.

Samenwerking vormt de kern van ons werk binnen het thema 'Health and well-being in a healthy society'.

Ontdek de carrièremogelijkheden na de MSc Nederlandse Politiek aan Universiteit Leiden: functies binnen politiek, beleid, onderzoek, advies en internationale organisaties.