2,421 zoekresultaten voor “war on drug” in de Publieke website
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Tangent fermions: massless fermions on a lattice
In some condensed matter systems, such as the surface of a 3D topological insulator, the electrons are effectively massless and we must necessarily use the massless Dirac equation to describe them.
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55th Colloquium on African Languages and Linguistics
Congres/symposium
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Dusty perspectives on the cradles of planets
De astronomie begon met het bestuderen van het licht van de sterren. Deze sterren worden geboren in uitgestrekte wolken van gas en stof.
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The impact of sustainable forest management on plant and bird diversity in East Kalimantan, Indonesia
Promotor: G.R. de Snoo, Co-promotor: H.H. de Iongh, C.J.M. Musters
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Discovery of antibiotics and their targets in multidrug-resistant bacteria
Global healthcare is on the verge of an antibiotic availability crisis as bacteria have evolved resistance to nearly all known antibacterials. Identifying new antibiotics that operate via novel modes-of-action is therefore of high priority.
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Optimisation of first clinical studies in special populations: towards semi-physiological pharmacokinetic models
M. Danhof, Co-promotores: J. Freijer, A. Yassen
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Searching by Learning: Exploring Artificial General Intelligence on Small Board Games by Deep Reinforcement Learning
In deep reinforcement learning, searching and learning techniques are two important components. They can be used independently and in combination to deal with different problems in AI, and have achieved impressive results in game playing and robotics. These results have inspired research into artificial…
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Approach to Markov Operators on Spaces of Measures by means of equicontinuity
The subject of this thesis, ‘Approach to Markov Operators on Spaces of Measures by Means of Equicontinuity’, combines an analytical and probabilistic approach to Markov operators.
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Neonicotinoids in nature: The effects on aquatic invertebrates and their role in ecosystems
This thesis describes the role of pollution, specifically neonicotinoid insecticides, as an actor of the ongoing biodiversity decline.
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Applications for activity-based probes in biomedical research on glycosidases
Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.
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Impact of low-carbon electricity development on carbon emissions in China
Low-carbon (LE) technologies have a significant potential to reduce the total carbon emissions in China.
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Sound Investigation: Effects of noise on marine animals across trophic levels
Anthropogenic noise has been shown to affect marine animals in various ways, this may have fitness consequences at individual and population level. This thesis aims to increase insight into the quantification of sound-induced behavioural responses that are relevant to fitness, and into factors that…
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Intent on the Paleolithic: Papers in honour of Prof.dr. Wil Roebroeks
This collection of papers was compiled in celebration of the remarkable academic career of Professor Wil Roebroeks, who has established himself as one of Europe’s leading figures in Palaeolithic archaeology over the past three decades and founded the Human origins research group at Leiden University…
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SPOT ON: studenten met perspectief in opleiding en toekomst. Ontwerpprincipes en netwerken
Hoe kunnen studenten in mbo- en hoger onderwijsinstellingen het beste worden ondersteund in hun studiekeuze en studieloopbaan met het oog op soepele in- en doorstroom in opleiding en werk?
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The impact of defense hormones on the interaction between plants and the soil microbial community
The soil ecosystem consists of the largest reservoir of biodiversity on Earth.
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Publiekssymposium over psychologische effecten van geneesmiddelen en recreatieve drugs
Heeft het gebruik van medicijnen en drugs invloed op mijn persoonlijkheid? Wat zijn de (langere-termijn) gevolgen van de leerpil 'Ritalin'? Kunnen (party)drugs en medicijnen met rijden in het verkeer samengaan? Wat doen verslavende stoffen met mijn brein?
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On the random-matrix theory of Majorana fermions in topological superconductors
The thesis mainly contributes to the characterization of Majorana fermions as they appear in the Condensed Matter context.
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Erik Danen benoemd tot hoogleraar Cancer drug target discovery
Met ingang van 1 april 2018 is Erik Danen benoemd tot hoogleraar Cancer drug target discovery bij het Leiden Academic Centre for Drug Research (LACDR). Zijn vakgebied is celbiologie van kanker, waarin hij zich richt op de achterliggende mechanismen bij uitzaaiingen en resistentie voor behandelingen.
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The noise of the hunt: effects of noise on predator-prey relationships in a marine ecosystem
The effects of anthropogenic noise on interactions between predators and their prey are still little understood.
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An Institutional Perspective on the United Nations Criminal Tribunals: Governance, Independence and Impartiality
Op 18 september 2019 verdedigde Huw Llewellyn zijn proefschrift 'An Institutional Perspective on the United Nations Criminal Tribunals: Governance, Independence and Impartiality'. Het promotieonderzoek is begeleid door promotoren prof.dr. N.M. Blokker en prof.dr. L.J. van den Herik.
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Impact of nitrogen fertilization on the soil microbiome and greenhouse gas emission
The use of N fertilizers has increased worldwide in the past century. While this increased input of N has increased food productivity, it has also contributed to decreases in biodiversity, soil quality and environmental health, including increases in greenhouse gas emissions.
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Computational, biochemical, and NMR-driven structural studies on histone variant H2A.B
Nature uses a special class of histone proteins, histone variants, to modulate the properties of chromatin at defined genomic locations.
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Putting a spin on it: amyloid aggregation from oligomers to fibrils
This thesis focuses on amyloid proteins, a class of proteins that convert into amyloid fibrils.
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The power of biotic ligand models : site-specific impact of metals on aquatic communities
Promotor: G.R. de Snoo, Co-promotores: M.G. Vijver, J.P.M. Vink
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Investigations on the role of impaired lysosomes of macrophages in disease
The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.
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Disrupting the transcriptional machinery to combat triple-negative breast cancer
Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.
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‘Lab on a chip’ gaat gezondheidszorg ingrijpend veranderen
Snelle en goedkope chips die extreem kleine hoeveelheden vloeistof (microfluïden) analyseren vormen de kern van gepersonaliseerde gezondheidszorg. Maar het ‘laboratorium op een chip’ is nog niet effectief genoeg. Dr. Paul Vulto en zijn onderzoeksteam ontwikkelden een techniek die het gebruik van microfluïdische…
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Improved Strategies for Distance Based Clustering of Objects on Subsets of Attributes in High-Dimensional Data
This monograph focuses on clustering of objects in high-dimensional data, given the restriction that the objects do not cluster on all the attributes, not even on a single subset of attributes, but often on different subsets of attributes in the data.
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Call for Papers: Perceptions of Just War in the Middle Ages (IMC 2025)
The Research Training Group “Byzantium and the Euro-Mediterranean Cultures of War” invites scholars to submit paper proposals for a series of sessions on “Perceptions of Just War in the Middle Ages” at the IMC 2025. These sessions aim to explore the diverse theological, philosophical, legal, and cultural…
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Microphysiological liver systems for in vitro modeling and industry implementation
This thesis tackles the difficulty of predicting the liver’s clinical response to novel therapies, a challenge arising from interspecies differences and limitations of existing in vitro models.
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Low-Energy Electron Microscopy on Two-Dimensional Systems: Growth, Potentiometry and Band Structure Mapping
Promotor: Prof.dr. J.M. van Ruitenbeek, Prof.dr. R.M. Tromp
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Studying the Benefits of Using UML on Software Maintenance: an Evidence-Based Approach.
Including modelling as part of software development appears to have various benefits.
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Effects of the early social environment on song and preference learning in zebra finches
Songbirds as vocal learners learn their songs and song preference from social tutors. Tutor choice for both song and preference learning are important to characterize for understanding individual learning performance and cultural transmission of song.
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evolution and plasticity of life histories upon variation in nutrition: on aging focused integrative approach
Promotores: Prof.dr. P.M. Brakefield, Prof.dr. B.J. Zwaan (Wageningen Universiteit)
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Visual Relation extraction Based on Deep Cross-media Transfer Network
Building a Deep Cross-media Transfer Network to extract visual relations that relieve the problem of insufficient training data for visual tasks.
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Low-temperature spectroscopic studies of single molecules in 3-D and on 2-D hosts
Spectroscopic studies on fluorescent single molecules in organic condensed matter does not only provide information about the molecule itself, but also its near environment. By suppression of phonon-induced broadening of spectral lines through cooling to low temperatures, small changes in the spectral…
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Towards responsible and resilient mineral supply chains, with case studies on cobalt, antimony, and zinc
To meet the rising demand for minerals driven by the global shift to clean energy technologies, ensuring responsible and resilient supply chains is critical. Minerals like cobalt, lithium, and nickel for batteries, neodymium and zinc for wind turbines, and indium for solar panels are essential.
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When galaxy clusters collide: the impact of merger shocks on cluster gas and galaxy evolution
Promotor: Prof.dr. H.J.A. Rottgering
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Impact of land use changes on the human-elephant conflict
Promotor: G.R. de Snoo, W. Kustiawan, Co-promotor: H.H. de Iongh
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High throughput microscopy of mechanism-based reporters in druginduced liver injury
Promotor: B. van de Water
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NMR structural studies of protein-small molecule interactions
Promotor: Prof.dr. M. Ubbink, Co-promotor: G. Siegal
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Sensing Transport
Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.
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Uncovering vulnerabilities in triple-negative breast cancer
Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.
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War and Peace Studies: Nieuwe CSM-track richt zich op moderne oorlog, oorlogsvoering en vredesopbouw
Oorlog en vrede bestuderen. Met de oorlog in Oekraïne is het onderwerp actueler dan ooit. In september start een nieuwe track van de MSc Crisis and Security Management (CSM): War and Peace Studies. Programmadirecteur van CSM, Ernst Dijxhoorn, vertelt over deze nieuwe opleiding, de totstandkoming en…
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Frans Osinga in de Volkskrant over toenemend interesse in War Studies
Frans Osinga, bijzonder hoogleraar War Studies verbonden aan ISGA, vertelt in de Volkskrant over de groeiende aandacht voor oorlog in de collegezalen.
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Chemical tools to study the cannabinoid receptor type 2
The cannabinoid receptor type 2 (CB2R) is associated with several inflammatory diseases with an unmet medical need (e.g. Alzheimers, multiple sclerosis, reumatoid arthritis). Development of new chemical biology strategies to study this protein is essential to aid future development of drugs for these…
- Collegereeks: Practitioners in War
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Clavis Aurea? Structure-enabled approaches of identifying and optimizing GPCR ligands
Promotores: A.P. IJzerman, H.W.T. van Vlijmen
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touch for the instrumental control of musical sound with an excursion on the computed retinal afterimage
Promotor: Prof.dr. S. Haring
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historical biogeography of Orchidaceae in Central America with emphasis on Costa Rica and Panama
In this thesis, I targeted the orchid genus Lepanthes, one of the six genera of angiosperms that surpasses 1,000 species in the Neotropics, as a study model to investigate the evolutionary processes that promoted species diversifications.