2,342 zoekresultaten voor “burger cell” in de Publieke website
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Accelerating the Photocatalytic Water Splitting in Catalyst−Dye Complexes
As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.
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Samen aan de slag met het plasticprobleem: hoe houd je burgers betrokken?
Wat motiveert burgers om mee te doen aan een citizen science-project over plasticvervuiling? En verandert die motivatie met de tijd? Op deze en andere vragen probeerde Liselotte Rambonnet antwoord te krijgen met haar onderzoek naar het Schone Rivieren-project. Rambonnet is promovendus bij het Instituut…
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Functional fluorescent materials and migration dynamics of neural progenitor cells
In this thesis, time-lapse fluorescent microscopy plays a pivotal role in investigating functional materials within living cells as well as the migratory behaviour of neural progenitor cells.
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Chemokine signaling mechanisms underlying inflammation and infection control: insights from the zebrafish model
This thesis focuses on the role of chemokine receptors CXCR3 and CCR2 in the inflammatory process and infection control using the zebrafish model.
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Morphogenesis and protein production in Aspergillus niger
Promotores: C.A.M.J.J. van den Hondel, V. Meyer, Co-promotor: A.F.J. Ram
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Towards artificial photosynthesis: resolving supramolecular packing of artificial antennae chromophores through a hybrid approach
Promotor: H.J.M. de Groot
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Ellis AizenbergFaculteit Governance and Global Affairs
e.aizenberg@fgga.leidenuniv.nl | 070 8009500
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Development of novel anti-cancer strategies utilizing the zebrafish xenograft model
In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…
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Design and Synthesis of Inhibitors and Probes for Sulfoquinovosidases and Xylanases
This thesis focuses on the design and synthesis of activity-based probes and inhibitors targeting enzymes involved in the degradation of specific plant glycans.
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Towards the development of synthetic vaccines against tuberculosis
The research described in this Thesis was aimed at designing and synthesizing nature-inspired compounds as part of TB vaccine discovery.
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The role of autophagy during carbon starvation in Aspergillus niger
Autopaghy is an intracellular degradation system which targets cytosolic components to lytic compartments for degradation and recycling of the building blocks of the cell.
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Adjuvanted nanoparticulate seasonal influenza vaccines
Promotor: W. Jiskoot, Co-promotor: A. Kros
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Applications for DNA-encapsulated silver clusters in physics, biology and medicine
We use DNA strands to stabilize few-atom silver clusters, which show unique optical and chemical properties. This thesis involves the study of these constructs for various applications.
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Bioorthogonal Antigens
The aim of this thesis is to explore the use of Bioorthogonal Antigens to study the cross-presentation pathway.
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Spin-label EPR Approaches to Protein Interactions
Promotor: Prof.dr. E.J.J. Groenen, Co-Promotor: M. Huber
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Transforming data into knowledge for intelligent decision-making in early drug discovery
Promotor: A.P.IJzerman Co-promotor: A. Bender
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Investigations on the role of impaired lysosomes of macrophages in disease
The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.
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The diverse roles of integrin α3β1 in cancer: Lessons learned from skin and breast carcinogenesis
In this thesis, we aim to shed light on the diverse and often opposing roles of integrin α3β1 in cancer.
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Development of an in vitro vascular network using zebrafish embryonic cells
One of the major limitations in culturing complex tissues or organs is the lack of vascularization in the cultured tissue. Development of a functional capillary bed could overcome this problem.
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Copper complexes for bioinspired electrocatalysis relevant to the reduction of oxygen
This thesis advance our understanding and the application of molecular catalysts relevant to the reduction of oxygen as well as reduction of nitrite.
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Squaramide-based interpenetrated networks for load-bearing applications
This thesis explores squaramide-based supramolecular polymers and hydrogels, enhancing their mechanical strength for 3D cell culture.
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Immune cell networks in Inflammatory Bowel Disease
Promotie
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The aging B cell landscape in atherosclerosis
Promotie
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Exploring and exploiting CD8+ T cell proliferation
Promotie
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Sylvia Le DévédecFaculteit der Wiskunde en Natuurwetenschappen
s.e.ledevedec@lacdr.leidenuniv.nl | 071 5274285
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Onvrede over Europa
Leidse wetenschappers onderzoeken Europese regelgeving en op welke manieren die regels op meer steun kunnen rekenen van de burgers van lidstaten.
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Integration and disentanglement of single-cell and spatial transcriptomics with applications in Autosomal Polycistic Kidney Disease
Promotie
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Herverdeling in de EU
De Unie dichter bij de burger: sociaal-psychologische inzichten in herverdeling op EU-niveau en waargenomen legitimiteit.
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Vertrouwen ten tijde van polarisatie
Meer vertrouwen van burgers in overheid, rechtsstaat en democratie.
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Hoe uitzaaiende tumoren hun omgeving naar hun hand zetten
Tumoren gedragen zich als mini-orgaantjes, manipuleren hun omgeving en gebruiken lichaamseigen processen om te overleven en uit te zaaien. Door onderzoek van Erik Danen en zijn collega’s komen we steeds meer te weten over de complexe aard van tumorcellen. In het NRC vertellen de wetenschappers over…
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Kostas TassisFaculteit der Wiskunde en Natuurwetenschappen
k.tassis@lacdr.leidenuniv.nl | 071 5276302
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Moet de overheid sociale media gebruiken om burgers te waarschuwen voor gewapende conflicten?
In een nieuw essay voor Ethics & International Affairs behandelt Dr. Henning Lahmann, universitair docent internationaal recht en technologie bij eLaw, de vraag of overheden hun toevlucht moeten nemen tot sociale media om burgerbevolking te waarschuwen voorafgaand aan militaire operaties.
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Is het gewenst als burgers verplicht worden om bewakingscamera’s te melden bij de overheid?
Wanneer er een overval of inbraak is geweest, kan de politie door de databank snel zien of er camera’s aanwezig zijn die mogelijke beelden van het incident hebben opgenomen. Deze camerabeelden kunnen van cruciaal belang zijn om misdrijven op te lossen. Moeten we het aanmelden van camera’s daarom niet…
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Hoe houd je burgers aangehaakt bij de democratie? Een interview met Carola Schoor
Als je makkelijke antwoorden wil op bestuurlijke vragen, kun je de democratie beter afschaffen, vindt dr. Carola Schoor. Want een democratie hoort te wringen en vragen op te roepen. Voor een evenwichtige en rechtvaardige rechtsstaat is ‘een rechtsstatelijk kompas’ nodig.
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Ahmed Mahfouz: 'Het mysterie van hersenziekten, cel voor cel uitgezocht'
Welke hersencel doet wát als bijvoorbeeld de ziekte van Parkinson ontstaat? Het duurt niet lang meer voordat die puzzel stukje voor stukje gelegd kan worden. Computationeel bioloog Ahmed Mahfouz combineert Leidse bio-kennis met Delftse algoritmen en komt steeds dichterbij de sleutel.
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Modulation of leukocyte homeostasis in atherosclerosis
Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel
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The interplay between lipids and the immune system in atherosclerosis
Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.
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Investigating lipid formulations for efficient RNA delivery using zebrafish models
Lipid formulations have demonstrated strong potential for nucleic acid delivery,particularly with the success of COVID-19 vaccines. Despite these advances, manyaspects of lipid formulations remain unclear.
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Enumeration and Simulation of Lattice Polymers as Models for Compact Biological Macromolecules
Promotores: H. Schiessel, G.T. Barkema
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Image analysis for gene expression based phenotype characterization in yeast cells
Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek
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Mesoporous silica nanoparticle-based protein delivery systems for biomedical applications
Promotor: A. Kros
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Bioorthogonal Labeling Tools to Study Pathogenic Intracellular Bacteria
In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.
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Chemical Tools to Illuminate N-acylphosphatidylethanolamine Biosynthesis
This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.
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Activity-based protein profiling of glucosidases, fucosidases and glucuronidases
Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea
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Caging ruthenium complexes with non-toxic ligands for photoactivated chemotherapy
The main goal of the research described in this thesis was the development of new photoactivated chemotherapy (PACT) ruthenium(II) complexes bearing a non-toxic photolabile ligand.
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Quantitative Super-Resolution Microscopy
Promotor: T. Schmidt
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Resistance to PARP inhibition by DNA damage response alterations in BRCA1/2-deficient tumors
Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.
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The ecological relevance of chemical diversity in plants
Promotor: P.G.L. Klinkhamer, Co-Promotores: K. Vrieling, P.P.J. Mulder
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Advances in GPCR Modeling Evaluated by the GPCR Dock 2013 Assessment: Meeting New Challenges
Source: Structure , Volume 22, Issue 8, pp. 1120-1139 (2014)
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Development of a Kidney-on-a-Chip Model for Compound Screening and Transport Studies
Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…