Over the last three decades, the discovery of exoplanets has revealed the boundless variety of worlds beyond our own Solar System⁠. Majority of planetary systems contain short-period planets that are larger than Earth but smaller than Neptune⁠.

We have studied shape with a particular focus on the zebrafish model system. The shape is an essential appearance of the phenotype of a biological specimen and it can be used to read out a current state or response or to study gene expression.

Promotores: A.P. IJzerman, H.W.T. van Vlijmen

The progressive loss and degeneration of dopaminergic neurons is a major pathological hallmark of Parkinson's disease (PD). The onset and progression of PD can be triggered by multiple risk factors, for instance, genetic mutation, environmental exposure, and aging.

In the search for sustainable energy solutions, the idea of artificial photosynthesis has been proposed as an approach with which to use water and sunlight to produce hydrogen.

The external tissues of plants and animals are colonized by microbial communities termed microbiota. When organisms are exposed to environmental pollutants, these substances will therefore encounter microbiota at the exposure interface.

The glycosylation reaction is a pivotal reaction in creating new and complex oligosaccharides.

Promotor: Prof.dr. R.M.H. Merks

As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.

Promotor: K.J. Batenburg

To improve cancer treatments, personalized medicine approaches have aimed to identify exactly which mutations are driving tumor development in a given patient and specifically target these mutations using precision therapies.

A modern ship design process is subject to a wide variety of constraints such as safety constraints, regulations, and physical constraints.

Promotor: W.Th.F. den Hollander Co-Promotor: F.M. Spieksma

This thesis considers multi-prover commitment schemes whose security is based on restrictions on the communication between the provers.

The overarching goal of this thesis is to set the foundations, but also make the first essential steps towards establishing a comprehensive, mesoscopic, hydrodynamic theory of epithelial tissues. The stage is set by an exhaustive study of topological defects in passive p-atic liquid crystals, singularities…

Projecten van de afdeling Environmental Biology

DNAmarkerpoint heeft als doel ecologie, evolutie en biodiversiteit beter te begrijpen door het bestuderen van modern en ancient DNA.

De nieuwste Europese quantumcomputer komt in Nederland. De ict-coöperatie van Nederlandse onderwijs- en onderzoeksinstellingen SURF krijgt hiervoor financiering van het Europese EuroHPC-programma. Leidse onderzoekers hebben een belangrijke rol: zij ontwerpen de algoritmes en de machine learning routes,…

De traditionele scheiding van leeuwen in een Afrikaanse en een Aziatische ondersoort is onterecht, zegt bioloog Laura Bertola. In Afrika leven twee ondersoorten. Promotie 18 maart.

Wiskunde en Natuurwetenschappen, Leids Instituut voor Chemisch Onderzoek (LIC)

Negen studenten doken deze zomer in een uitdagend iGEM-project. Met hun idee willen ze antilichamen efficiënter maken – en leren ze ondertussen minstens zoveel over samenwerking, creativiteit en hun eigen toekomst.

Wiskunde en Natuurwetenschappen, Leids Instituut voor Chemisch Onderzoek (LIC)

What is the optimal design of sandy solutions for sustainable climate change adaption, from an ecological, biophysical and societal point of view?

Tientallen jaren hebben taalwetenschappers zich het hoofd gebroken over de vraag hoe de zinsbouw van talen precies verschilt. Promovendus Martin Kroon ontwikkelde een computersysteem dat een antwoord dichterbij brengt. Promotie op 10 november.

Promotor: G. A. van der Marel, Co-promotor: D. V. Filippov

Leiden University offers a unique range of summer courses where you can broaden or deepen your knowledge or share your expertise with fellow students. The choice of academic courses is very diverse, ranging from Law, Big Data, Languages and Linguistics to Maths and Natural Sciences, Biology, Biomedical…

This thesis has described novel synthetic methods to produce a variety of (glyco)peptides and their application in the study of various immunological processes.

If mankind wants to survive into the 22nd century, we will need to change the way we live drastically. The human impact on our planet is everywhere, we are changing the atmosphere, the oceans and the land, leading to global warming, climate change, loss of biodiversity and pervasive pollution. There…

This multidisciplinary minor provides students with knowledge on how and why humans became the way they are. The minor focuses on the evolution of the species Homo sapiens from other hominin lineages and animal ancestors, and on the various factors shaping this process. Not only is human evolution of…

The primary goal of this research is to deepen our understanding of substrate-enzyme interactions in Glycoside hydrolases. For this purpose, Bacillus circulans xylanase (BcX) has been selected as a well-established model to examine the Michaelis complex and glycosyl-enzyme adduct.

hotocatalysis has emerged as a powerful tool for enabling challenging transformations in organic synthesis. This thesis explores the development of several photocatalytic reactions designed to form carbon-heteroatom bonds from less-functionalized precursors.

Endocannabinoids are lipid messengers that modulate various physiological functions by activating the cannabinoid CB1 and CB2 receptors. While the metabolism of endocannabinoids and their action at the CB receptors is fairly well studied, the molecular mechanisms governing their release and transport…

This thesis explores squaramide-based supramolecular polymers and hydrogels, enhancing their mechanical strength for 3D cell culture.

In 2015 the Pascalchair of the Faculty of Science, Universiteit Leiden and in particular of Leiden Institute of Advanced Computer Science, is held by Prof. Dr. Natasa Jonoska, University of South Florida, Tampa, USA.

Het merendeel van de wetenschappers, van archeologen tot zoölogen, verzamelt enorme hoeveelheden gegevens. Hun databanken bevatten grote hoeveelheden informatie die voor de mens moeilijk te filteren zijn. Met een stevige basis in de statistiek en de computerwetenschappen kunnen we algoritmes ontwikkelen…

Promotie

De Nobelprijs voor Scheikunde 2017 is uitgereikt aan Jacques Dubochet, Richard Henderson en Joachim Frank, voor hun ontwikkeling van de cryo-elektronenmicroscopie. Met deze techniek kunnen biomoleculen in 3D in beeld gebracht worden, legt hoogleraar Ultrastructuurbiologie Ariane Briegel uit.

Aan de Universiteit Leiden werken wetenschappers uit alle disciplines samen om antwoorden te vinden en om te innoveren op het gebied van kunstmatige intelligentie.

Antibiotic-resistant bacteria pose a major health threat. Addressing this challenge requires among others the development of new antibacterial compounds. The research described in this thesis focuses on discovering novel antibiotics from soil bacteria, specifically Streptomyces and Paenibacillus.Despite…

This thesis focuses on addressing four research problems in designing embedded streaming systems.

Dit project ontwikkelt methoden om de anonimiteit van individuen in sociale netwerkgegevens te waarborgen.

Computational thinking, programming, and algorithms form the basic of many of the things that are shaping our world, the way we work, interact, organize ourselves, and even spend our free time with social networks, streaming media, and games. And this transformation is far from being complete, it is…

‘We moeten op zoek naar producten die gewone wegwerpplastics kunnen vervangen, bijvoorbeeld van plantmateriaal. Binnen een jaar of 20 is het gemiddelde plasticgebruik van een huishouden met grote slagen verminderd.’ Volgens Thijs Bosker, Universitair Hoofddocent aan het Leiden University College, in…