2,673 zoekresultaten voor “dutch east in a” in de Publieke website
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A chemical biology approach to explore lipid metabolism in neurological disorders
Neurodegenerative diseases pose a large medical and societal challenge. The etiology of these diseases is still poorly understood, which makes drug discovery for these diseases difficult.
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Modelling the dynamics of the innovation process: a data-driven agent-based approach
Promotor: Prof.dr. B.R. Katzy
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Reverse engineering of drug induced QT(c) interval prolongation: Towards a systems pharmacology approach
Promotor: M. Danhof Co-promotor: O.E. Della Pasqua
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The architects of crenarchaeal chromatin: A biophysical characterization of chromatin proteins from Sulfolobus solfataricus
Promotor: Jaap Brouwer, Co-promotor: Remus Th. Dame
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Giant barrel sponges in diverse habitats: a story about the metabolome
Marine sponges are important members of reef ecosystems, as they play ecological roles that are essential for the health of the reef.
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A Model Membrane Approach to Elucidate the Molecular Organization in the Skin Barrier
Promotor: J. A. Bouwstra
- Symposium: A Dutch Perspective on Mycobacterial Infections
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Monitoring drought and salinity stress in agriculture by remote sensing for a sustainable future
Food security is challenged by a growing global population and by climate change. Drought and soil salinity are considered the most important ones that inhibit crop yield and distribution. Worryingly, climate change is predicted to increase not only their frequency and severity, but also their co-occurrence,…
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Putting a spin on it: amyloid aggregation from oligomers to fibrils
This thesis focuses on amyloid proteins, a class of proteins that convert into amyloid fibrils.
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Differentiated instruction in practice: a teacher perspective
Veel docenten in het voortgezet onderwijs houden rekening met verschillen tussen leerlingen. Uit het promotieonderzoek van Saskia Stollman (ICLON) blijkt dat zij hierbij ruimte om te experimenteren en ondersteuning van de school(leiding) nodig hebben.
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Playing a role – but which one?
Individuen die werken in de publieke sector zien zichzelf geconfronteerd worden met tegenstrijdige waarden, tegenstrijdige eisen en de noodzaak van het dienen van het soms moeilijk definieerbare publieke belang.
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The relation between dynamics and activity of phospholipase A/acyltransferase homologs
Phospholipase A/acyltransferase 3 (PLAAT3) and PLAAT4 are enzymes involved in the synthesis of bioactive lipids. Despite sequential and structural similarities, the two enzymes differ in activity and specificity.
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dosing of serotherapy in allogeneic hematopoietic cell transplantation - a delicate balance
Promotor: C.A.J. Knibbe, Co-promotor: J.J. Boelens, R.G.M. Bredius
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Coiled-coils on lipid membranes: a new perspective on membrane fusion
Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros
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changes for long term impact: optimization of structure kinetic properties: a case of CCR2 antagonists
Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman
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Molecular inheritance from cloud to disk: a story of complex organics and accretion shocks
Stars like the sun are born in large molecular clouds existing from gas and dust. During the formation process, the chemical composition of the material can be altered drastically by the changing physical conditions.
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Towards a Circular Food System: Global Resource Losses, Waste Typologies, and Valorization Pathways
Food waste is a defining inefficiency of the modern food system, with profound implications for resource use, climate change, and circular economy transitions. This dissertation examines food waste through two complementary lenses: the prevention of avoidable food waste and the valorization of unavoidable…
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The writing culture of ancient Dadan; a description and quantitative analysis of linguistics variation
Fokelien Kootstra verdedigde haar proefschrift op 23 april 2019
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Online Course Anatomy of the Abdomen and the Pelvis: a journey from basic to clinic
In this course, you will explore the organs involved in our food digestion and discover the common causes of abdominal and pelvic pain. The latest graphics and animations will give you new insights and understandings of this part of the body.
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Facets of radio-loud AGN evolution: a LOFAR surveys perspective
Promotor: H.J.A. Rottgering, Co-Promotor: R.J. van Weeren
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Azië
Azië en Europa hebben in toenemende mate met elkaar te maken. Om een duurzame samenwerking te bevorderen is het belangrijk elkaar op economisch, sociaal-cultureel, historisch, en juridisch gebied beter te begrijpen. Leidse wetenschappers leveren al decennia een belangrijke bijdrage aan de verwerving…
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De overlegeconomie internationaal vergeleken
De overlegeconomie is nog springlevend, concludeert Jeroen Touwen in een lijvige studie van 385 pp. naar de geschiedenis van zestig jaar overleg en onderhandelen in de Nederlandse economie. Dankzij formele regelgeving, bereidheid tot aanpassen, het afbakenen van marktwerking binnen nauwgedefinieerde…
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A molecular journey : tales of sublimating ices from hot cores to comets
The thesis explores how interstellar chemistry evolves as a function of time and changing physical architectures during the formation of stars.
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Aanbieding vijfde druk Introduction to Dutch Law aan mr. G. Corstens
Op vrijdag 22 april werd tijdens de jaarvergadering van de Vereniging voor Rechtsvergelijking in Utrecht de vijfde druk van het door Jeroen Chorus, Ewoud Hondius en Wim Voermans geredigeerde boek ‘Introduction to Dutch Law’ aangeboden aan mr. Geert Corstens, oud-president van de Hoge Raad.
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VICI voor Mirjam de Bruijn
Het Instituut voor Geschiedenis feliciteert Mirjam de Bruijn met het verkrijgen van een VICI-subsidie voor het onderzoek 'Connecting in Times of Duress: Understanding Communication and Conflict in Middle Africa’s Mobile Margins.'
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Drug-target residence time: a case for the adenosine A1 and A2A receptors
Promotor: A.P.IJzerman, Co-Promotor: L.H. Heitman
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A well-established harmony in chaos: from isolated galaxies to galaxy clusters
The origin and evolution of galaxies are closely linked to many different physical phenomena.
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Unveiling the third dimension: vertical structure as a probe of planet formation conditions
Protoplanetary disks are the gas and dust environments where planetary systems form around young stars. Using observations from the Atacama Large Millimeter/submillimeter Array (ALMA) this thesis analyses the gaseous molecular reservoir, using multiple tracers to resolve the 3D structure of protoplanetary…
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Functionalizing monolayer graphene as a proton-selective membrane for direct methanol fuel cells
This thesis focused on the exploration of monolayer graphene as a membrane in direct methanol fuel cell (DMFC) applications, with improvements achieved through plasma exposure or damage- free chemical functionalization.
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Van Vonno, Achieving Party Unity: A Sequential Approach to Why MPs Act in Concert (dissertatie)
Cynthia van Vonno, politicoloog aan de Universiteit Leiden, verklaart in haar proefschrift waarom individuele parlementariers meestemmen met hun fractie.
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From stress to success; How actinobacteria exploit live without a cell wall
The aim of this thesis was to study phage infection in Streptomyces, focused on cell wall-deficient cells. Bacteriophages (or phages in short) attach to the cell wall of bacteria after which they replicate and lyse the host cell.
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Unraveling the surface formation of regular and deuterated water in space: a combined laboratory and computational study
Promotor: Prof.dr. H.V.J. Linnartz
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Towards a system-based pharmacology approach to predict developmental changes in renal drug clearance in children
Promotores: Prof.dr. C.A.J. Knibbe, Prof.dr. M. Danhof, Prof.dr. K. Allegaert (Leuven)
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Designing 'context-specific' regional innovation policy: a study on the role of regional government in six European regions
Whilst government’s ability to design ‘context-specific’ regional innovation policy is generally assumed to depend on the region’s decision-making power, the aim of this study is to investigate how regional government matters. In order to open up the black box of policy design, the study develops a…
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Digging for data: the rise and fall of a Miocene mammal biodiversity hotspot in the Vallès-Penedès (Catalonia, Spain)
The Vallesian, 11.1-9 Ma, was a special time in the Vallès-Penedes basin near Barcelona, where a biodiversity hotspot existed. Europe had a subtropical climate, with rhinos, forest giraffes, lions, hyenas, flying squirrels and primates.
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A search for transient reductions in the speed of sound of the inflaton in cosmological data, and other topics
Promotor: Prof.dr. A. Achucarro
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Formulation of influenza T cell peptides: In search of a universal influenza vaccine
Promotores: Prof.dr. G.F.A. Kersten, W. Jiskoot, Co-promotor: J-P. Amorij
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A pharmacognostic study of Vernonia guineensis Benth. (Asteraceae): bioactivity, safety, and phytochemical analysis
Promotor: Prof.dr. R. Verpoorte, Co-Promotor: Dr. Young Hae Choi
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From a Biased Perspective: Quasars, Mergers, and Planet-Forming Discs
This thesis is a (biased) journey through very different topics in astrophysics: quasars and new populations of active galactic nuclei, gravitational waves from merging black holes, and protoplanetary discs around young stars.
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Evolutionary adaptability of β-lactamase: a study of inhibitor susceptibility in various model systems
β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…
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The electrode-electrolyte interface in CO2 reduction and H2 evolution: a multiscale approach
Electrocatalysis allows for storing electricity or converting it into chemical bonds, producing chemical building blocks and fuels using renewable resources.
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Photoinduced processes in dye-sensitized photoanodes under the spotlight: a multiscale in silico investigation
With increasing carbon dioxide levels in the atmosphere and their detrimental effect on the global climate, modern society needs to push for more renewable energy sources. Storing widely accessible and abundant solar energy in chemical bonds in the form of molecular fuel via artificial photosynthesis…
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A New Model of Global Governance in International Tax Law Making (GLOBTAXGOV)
Dr. Irma Mosquera Valderrama onderzoekt in haar ERC-project de rol van de OESO (Organisatie voor Economische Samenwerking en Ontwikkeling) en de EU bij de totstandkoming van internationale fiscale wetgeving en streeft ernaar voorwaarden te scheppen waaronder zowel ontwikkelde landen als ontwikkelingslanden…
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Shielding software systems: A comparison of security by design and privacy by design based on a systematic literature review
De auteurs zoeken en beoordelen systematisch relevante definities van Security by Design (SbD) in vergelijking met Privacy by Design (PbD).
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Blijvende anti-Russische politiek in Westen onverstandig
Het Westen, de VS en de EU voorop, probeert voor Rusland de prijs van de oorlog op te voeren, door Oekraïne met geld en wapens te steunen en door Rusland uit te sluiten van financiële markten. Maar een voortdurende anti-Russische politiek, betoogt politicoloog Hans Oversloot (Universiteit Leiden), is…
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'Een Disneyversie van Nimrud brengt de geschiedenis niet terug'
De Iraakse archeologische site Nimrud werd kort geleden terugveroverd op IS. Maar wat nu te doen met de beschadigde resten? Bleda Düring sprak erover in Trouw.
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Engaging with climate diplomacy: Lessons from Dutch UNFCCC Negotiators
Discover the unique Vital Interests course in the BSc Security Studies programme, featuring an inspiring session on climate diplomacy with Dutch UNFCCC negotiators.
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Joost Kok in Leidsch Dagblad over Dutch Sport Data Centre
Wetenschappers van de Universiteit Leiden werken samen met de schaatsploeg van Jac Orie om te bepalen welke mix van verschillende trainingen voorafgaand aan een wedstrijd het beste is om optimaal te presteren. Joost Kok, hoogleraar informatica: 'We willen dé hoofdstad van de sport data valley van Nederland…
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Disentangling a complex genus: systematics, biogeography and bioactivity of the genus Phyllanthus L. and related genera of tribe Phyllantheae
The largest genus within the Phyllanthaceae family is a group called Phyllanthus L. Recent studies have shown, that Phyllanthus is paraphyletic with the genera Glochidion, Breynia and Synostemon nested within it.
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Towards a greater understanding of the presence, fate and ecological effects of microplastics in the freshwater environment
This thesis combines field and laboratory studies to address some of the most pressing questions in the field of microplastic research.