In this book liposomes are explored as delivery system for allergen-specific immunotherapy. Both cationic and anionic formulations are prepared with Bet v 1, one of the allergens in birch pollen.

We simuleren interstellaire wolken met speciale plasma-expansies en chemische reacties op ijzige stofdeeltjes in ultrahoogvacuümopstellingen. Dit levert gegevens die nodig zijn om astronomische waarnemingen te interpreteren en de reactienetwerken in de ruimte te modelleren.

Eduard Fosch-Villaronga en Hadassah Drukarch van eLaw - Centrum voor Recht en Digitale Technologie, publiceerden onlangs het boek 'AI for Healthcare Robotics', uitgegeven door CRC Press van Taylor en Francis Group in hun AI for Everything-serie.

Broedplaats voor innovatie en ondernemerschap.

Commerciële bedrijven die gebruik willen maken van de expertise en faciliteiten worden doorverwezen naar LAB , de commerciële eenheid die verantwoordelijk is voor gespecialiseerd laboratoriumwerk.

Studievoorlichting, Webinar

Het boek 'Fit for the future' bundelt de bijdragen van Leidse wetenschappers en behandelt de uitdagende onderwerpen op de agenda van het Nederlandse EU-voorzitterschap 2016.

Three major cosmology-focused missions are planned for the next decade: the Euclid space telescope, the Vera C. Rubin Observatory in Chile, and the Nancy Grace Roman Space Telescope.

The availability of indicators based on social media has opened the possibility to track the online interactions between social media users and scholarly entities.

Promotor: Prof.dr. J. Kuiper

Lipid formulations have demonstrated strong potential for nucleic acid delivery,particularly with the success of COVID-19 vaccines. Despite these advances, manyaspects of lipid formulations remain unclear.

Despite the fact that gold nanoparticles (GNPs) are one of the most studied nanoparticles, there is still a necessity for new approaches allowing for effective protective coating to enable wider use of GNPs in biomedical applications.

Visualizing the internal structure is a crucial step in acquiring knowledge about the origin, state, and composition of cultural heritage artifacts. Among the most powerful techniques for exposing the interior of cultural heritage objects is computed tomography (CT), a technique that computationally…

The next generation of high-contrast imaging instruments on space-based observatories requires sophisticated wavefront sensing and control in addition to a high-performance coronagraph.

In this dissertation, the synthesis and characterization of a series of iron complexes based on different ligand platforms are described.

The aim of the research presented in this thesis was to develop new methods forchallenging systems in liquid-state NMR using paramagnetic effects generated by thetwo-armed probe CLaNP-5.

Sepsis is a life-threatening condition caused by a dysregulated host response to infection, it is associated with significant morbidity, mortality, and with a high financial burden on global healthcare systems. Bacterial infections are the primary cause of sepsis, but the growing prevalence of antimicrobial…

Let A be a commutative algebraic group over a field K, and let G be a finitely generated subgroup of the K-rational points of A. The purpose of this thesis is to study the degrees of the Kummer extensions relative to A,K and G.

The research in this thesis is focused on tomographic reconstruction based on two imaging modalities in electron microscopy.

Sewer pipes are an essential infrastructure in modern society and their proper operation is important for public health. To keep sewer pipes operational as much as possible, periodical inspections for defects are performed.

Urbanisation is steadily increasing with estimates expecting that 68% of the global population will live in cities by 2050. To accommodate the rural to urban transition, large quantities of land are transformed from natural to urban lands.

Bij de militaire parade in Bejing werd een foto van Xi Jinping gemaakt met allerlei buitenlandse gasten. Sommigen met een hoge functie, anderen nagenoeg onbekend. In NRC vertelt emeritus hoogleraar Frank Pieke meer over de reden van zo’n foto.

The main objective of this thesis was to develop clinically relevant survival models for patients with high-grade soft tissue sarcoma of the extremities, in particular the development and validation of prediction models for use in clinical practice.

Explaining treatment response variability between and within patients can support treatment and dosing optimization, to improve treatment of individual patients.

In this thesis chemical and physical processes in the ice mantles on interstellar dust grains are studied.

In this work we describe three methods to improve the performance of Quantum Field Theory calculations.

In this thesis we study quantum transport phenomena on the nanometer scale, in two classes of materials: topological insulators with induced superconductivity and graphene superlattices.

In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.

This thesis explores squaramide-based supramolecular polymers and hydrogels, enhancing their mechanical strength for 3D cell culture.

Photocatalysis has emerged as a powerful tool for enabling challenging transformations in organic synthesis. This thesis explores the development of several photocatalytic reactions designed to form carbon-heteroatom bonds from less-functionalized precursors.

Decarbonizing the building stock is critical for realizing the climate-neutral target for the Netherlands.

China vormt geen directe militaire dreiging voor Europa bepleit Friso Stevens, buiten promovendus aan het Institute of Security and Global Affairs (ISGA), in Clingendael Spectator. Hij reageert hiermee op Henk Schulte Nordholt en Alex Krijger die in De Volkskrant volgens Stevens Nederland en Europa…

Universitair docent Oost-Azië Studies Casper Wits geeft in NRC zijn visie op Taiwans uitsluiting van internationale organisaties. China's groeiende invloed leidt tot Taiwans isolement, wat mogelijk een opmaat is naar conflict.

“Hoe meer het reguliere bankwezen wordt gereguleerd, des te groter zal het schaduwbankwezen worden.”

De universiteit zal de overeenkomst met het instituut niet verlengen na 31 augustus 2019, na afloop van de huidige termijn.

In this thesis, we describe the potential of cell mechanical phenotyping for immune cell characterization, diagnosis, drug testing, as well as treatment of disease.

Promotor: Prof.dr. P. Stevenhagen

Self-assembly is an abundant process in nature and is vital to many processes in living organisms.

Mining time series is a machine learning subfield that focuses on a particular data structure, where variables are measured over (short or long) periods of time.

Polymyxins are clinically used antibiotics, discovered in mid-20th century. Once abandoned due to excessive nephrotoxicity, they are now used increasingly to address infections caused by multi-drug resistant Gram-negative bacteria.In this thesis, we describe the development and synthesis of analogues…

Inspired by natural photosynthesis, perovskite-based photoelectrochemical (PEC) systems are being developed for artificial photosynthesis, aiming to enhance solar-to-hydrogen conversion for green energy.

Promotor: Prof.dr. J.N. Kok, Co-Promotor: W.A. Kosters

Organic amendments applied to agricultural fields can partially offset our carbon emissions to the atmosphere and improve the resilience of agriculture to the effects of climate change. Driving these benefits, however, are complex and poorly understood interactions between organic amendment properties,…

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

The field of exoplanet research is rapidly advancing through the development of new technology, observing techniques, and post-processing methods.

This thesis is concerned with the constitution of chiral responsive matrix assemblies that may undergo light-driven conformational changes and self-select vibrations to develop vibronic states for driving semi-classical coherent transfer with nearly 100% yield in a lossless NCAP process.

Complex Organic Molecules (COMs) have been detected in objects across different stages of stellar evolution.

This dissertation focuses on developing new mathematical and statistical methods to properly represent time-varying covariates and model them within the context of time-to-event analysis.

This dissertation consists of two parts, each of which considers a different research area related to random interval maps. In the first part we are interested in random interval maps that are critically intermittent.