1,854 zoekresultaten voor “war on drug” in de Publieke website
-
The Impact of Name Writing on Early Literacy
-
-
Erasmus+ Project on Fact-Checking and Media Literacy
Europees samenwerkings- en trainingsproject om fakenews te identificeren, voorkomen en te bestrijden.
-
On the Term “Environmental Refugee”: Normative Assumptions and Empirical Realities
De auteurs vergelijken aannames over het normatieve nut van de term 'milieuvluchteling' met empirische bewijs van die term anders dan 'milieumigrant'.
-
On some classes of modules and their endomorphism rings
Promotores: Prof.dr. H Lenstra, Prof.dr. A Facchini (Padova University)
-
On quantum transport in flat-band materials
The studies in this thesis are focused on the physical effects in the flat band materials. The results contain the discovery of strong enhancement of RKKY spin-spin interactions with specific geometric arrangement and dynamical generation of excitonic order parameter with high magnitude.
-
Methods to simulate fermions on quantum computers with hardware limitations
This thesis is a collection of theoretical works aiming at adjusting quantum algorithms to the hardware of quantum computers.
-
Temperature and pressure effects on the electrochemical CO2 reduction
In eight chapters, the thesis of Rafaël Vos covers the effect of temperature and pressure on the electrochemical CO2 reduction.
-
Studies on the Pathogenesis of Chronic Kidney Disease
In this thesis, two potential therapeutic targets for diabetic nephropathy were dentified and investigated. First, we show that glomerular clusterin is upregulated in diabetic nephropathy and demonstrated that recombinant clusterin protein can protect the podocytes against oxidative stress in vitro.…
-
Assessing the impact of federalism on constitutional compliance
Kantorowicz en Voigt onderzoeken of federale systemen, met hun meerdere bestuursniveaus, leiden tot hogere constitutionele naleving.
-
Researching Extremists and Terrorists: Reflections on Interviewing Hard-to-Reach Populations
In deze publicatie verkennen Sarah Louise Carthy en Bart Schuurman de realiteit van het benaderen en interviewen van moeilijk bereikbare bevolkingsgroepen.
-
Oxidation catalysis on Pt and Au: complexity of simple chemistry
Promotor: J.W.M. Frenken Co-Promotores: I.M.N. Groot; L.B.F. Juurlink
-
On the coexistence of Landau levels and superconductivity
In unconventional high temperature superconductors, supercurrent vortices are known to spoil the Landau levels. In this thesis the emergence of Landau levels is studied in different types of superconductors: Weyl superconductors, and the Fu-Kane heterostructure.
-
Research Handbook on Public Affairs Connecting Evidence and Strategy
Arco Timmermans' handboek brengt experts samen om het vakgebied public affairs, de uitdagingen ervan en de relatie met democratie te verkennen.
-
Hard power and the European Convention on Human Rights
Op 18 juni 2019 verdedigde Peter Kempees zijn proefschrift 'Hard power and the European Convention on Human Rights'. Het promotieonderzoek is begeleid door promotoren prof. dr. R.A. Lawson en prof. dr. H. Duffy.
-
About Time: Implications of Chronoactivity on Health and Disease
Promotie
-
Electroextraction approaches for preconcentration of metabolites
In this thesis, we developed new ways to use a technique called electroextraction (EE) to extract charged molecules from one liquid into another using an electric field.
-
Getting personal: Advancing personalized oncology through computational analysis of membrane proteins
Cancer is considered the silent pandemic of the 21st century and the second leading cause of death worldwide.
-
LED3 & LUCID Drug Discovery Meeting
Congres/symposium
-
Antibiotic Conjugates and Natural Products as Next-Generation Strategies Against Antimicrobial Resistance
This thesis tackles the urgent challenge of antimicrobial resistance (AMR) through the design of novel antibacterial agents.
-
Promoveren aan twee universiteiten op drugsmisbruik
Stimulerende drugs als khat en cocaïne hebben negatieve impact op dagelijkse handelingen als autorijden, werk of sociaal gedrag. Dat komt door beschadiging van controlefuncties in de hersenen. Psycholoog Manuel Ruiz draagt bij aan beter begrip en behandeling van drugsmisbruik. De Spanjaard Ruiz promoveert…
-
noise in the Anthropocene: an impact study of human-made impulsive sounds on free-ranging cod
Sound is everywhere in the marine environment and hearing is therefore a very important for stimuli for fish. They use sound for orientation and communication, during migration, aggregation and spawning, but also for detection of prey and predators.
-
Design and application of dextran based cross-linked networks
This thesis describes the design, characterization and application of dextran based crosslinked network.
-
The interplay between lipids and the immune system in atherosclerosis
Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.
-
Ruthenium-peptide conjugates for targeted phototherapy
As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.
-
It's about time
This thesis explored the molecular pharmacological mechanisms of targeting CB2R via investigation of novel drug discovery concepts such as target binding kinetics, allosteric modulation and biased signaling.
-
On a quest to discover where stellar-mass black holes merge: testing the AGN binary formation channel with spatial correlation analyses
The physical origin of the dozens of stellar-mass binaries, the mergers of which have been detected by the LIGO-Virgo-KAGRA collaboration via gravitational waves, is still unknown.
-
Biophysical characterization of membrane protein-small molecule interactions
Promotor: Prof.dr. M. Ubbink
-
The Interactions of Human Mobility and Farming Systems and Impacts on Biodiversity and Soil Quality in the Western Highlands of Cameroon
Promotors: Prof.dr. G.R. de Snoo, Prof.dr. G.A. Persoon, Prof.dr.ir. H.H. de Iongh
-
hiding and disclosing: assessing the spread and stagnation of information on two new EMTCT policies in a Malawian village
Announcement of a new publication by Janneke Verheijen, lecturer at the Institute of Cultural Anthropology and Development Sociology.
-
Thermostable Nanodiscs for the development of novel biopharmaceuticals
Nanodiscs are small, disc-shaped structures designed to mimic biological cell membranes, composed of a lipid bilayer stabilized by scaffold proteins. Membrane proteins play crucial roles in essential processes such as nutrient and waste transport, molecular recognition, and cell signalling, making them…
-
Microneedle-mediated vaccine delivery
Promotores: Prof.dr. J. A. Bouwstra, Prof.dr. W. Jiskoot
-
Encompass goes on!
The ministry of education (OC en W) has generously decided to subsidize the Encompass program with a grant of 1 million euro’s for the years 2012-2016.
-
Translational pharmacokinetics-pharmacodynamics in zebrafish: integration of experimental and computational methods
The zebrafish is a promising vertebrate model organism in early drug discovery and development.
-
Discovery of FLT3 inhibitors for the treatment of acute myeloid leukemia
The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.
-
Cancer chess: molecular insights into PARP inhibitor resistance
The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…
-
Upconverting nanovesicles for the activation of ruthenium anti-cancer prodrugs with red light
Promotor: E. Bouwman, Co-promotor: S. Bonnet
-
Affinity-based profiling of the adenosine receptors
The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.
-
Flow and Vasculature in Organ-on-a-Chip systems
Drug development critically depends on preclinical models that mimic human physiology, yet traditional two-dimensional cultures and animal models often lack predictive power.
-
Singing is silver, hearing is gold: impacts of local FoxP1 knockdowns on auditory perception and gene expression in female zebra finches
The experiments described in this thesis employ local lentiviral knockdowns in brain areas of female zebra finches followed by behavioural assays consisting of preference and Go/Nogo tasks.
-
The impact of climate variability on the ecology of a lion (Panthera leo Linnaeus 1758) population and lion livestock conflicts in the Amboseli
Promotor: Prof.dr. G.R. de Snoo, Prof.dr. G.A. Persoon, Co-promotor: H.H. de Iongh
-
Marina Gorostiola GonzálezFaculteit der Wiskunde en Natuurwetenschappen
m.gorostiola.gonzalez@lacdr.leidenuniv.nl | 071 5272727
-
Glucocorticoid modulation of the immune response
Glucocorticoids (GCs) are widely prescribed as anti-inflammatory drugs due to their well-established immunosuppressive effects.
-
Medical Delta café: translation models for drug discovery and development, 8 oktober 2013
Onze gemiddelde leeftijd gaat omhoog en de behoefte naar goede gezondheidszorg wordt steeds groter. Nieuwe medicijnen moeten op de markt komen maar kosten voor de ontwikkeling daarvan moeten omlaag. Tijdens het Medical Delta café op 8 oktober presenteren o.a. dr. Leo Price, dr. Jan de Sonneville en…
-
Quantitative systems pharmacology modeling of biotherapeutics in oncology
In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.
-
Legal Perspectives on the Cross Border Operations of Unmanned Aircraft Systems
Op 14 november 2019 verdedigde Luis Fiallos Pazmino zijn proefschrift 'Legal Perspectives on the Cross Border Operations of Unmanned Aircraft Systems'. Het promotieonderzoek is begeleid door promotoren prof.dr. P.M.J. Mendes de Leon en prof.dr. E.C.P.D.C. De Brabandere.
-
EU Bank Resolution Framework: A comparative study on the relation with national private law
Op 19 september 2019 verdedigde Lynette Janssen zijn proefschrift 'EU Bank Resolution Framework: A comparative study on the relation with national private law'. Het promotieonderzoek is begeleid door promotoren prof.mr. W.A.K. Rank en prof.mr. M. Haentjens.
-
Parallel Enforcement of International Cartels and Its Impact on the Proportionality of Overall Punishment
Op 10 maart 2021 verdedigde Pieter Huizing zijn proefschrift 'Parallel Enforcement of International Cartels and Its Impact on the Proportionality of Overall Punishment'. Het promotieonderzoek is begeleid door promotor prof.mr. T.R. Ottervanger.
-
On the margins. Crime, gender and migration in early modern Frankfurt am Main, 1600-1800
Het centrale doel is de systematische bestudering van verschillen in criminaliteitspatronen en sociale controle tussen migranten en niet-migranten in het vroegmoderne Frankfurt am Main.
-
Quantum machine learning: on the design, trainability and noise-robustness of near-term algorithms
This thesis addresses questions on effectively using variational quantum circuits for machine learning tasks.
-
Essays on trends in income distribution and redistribution in affluent countries and China
De wereldwijde ongelijkheid neemt steeds meer toe. Het is belangrijk om de oorzaken te weten zodat de toenemende ongelijkheid bestreden kan worden.