Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

De Universiteit Leiden heeft onderzoeksinstituten gevestigd in Leiden en Den Haag.

Het Leiden Leadership Centre is een internationale en interdisciplinaire netwerkorganisatie. In onze aanpak brengen we mensen met verschillende achtergronden en diverse perspectieven samen

Make use of this time to improve your language skills by signing up for custom-made online language classes.

Promotores: Prof.dr. G.F.A Kersten, Prof dr. J.A. Bouwstra

This collection of papers was compiled in celebration of the remarkable academic career of Professor Wil Roebroeks, who has established himself as one of Europe’s leading figures in Palaeolithic archaeology over the past three decades and founded the Human origins research group at Leiden University…

Studievoorlichting

Als alumnus van de Universiteit Leiden kunt u uw hele leven lang gebruik blijven maken van de Universitaire Bibliotheken Leiden (UBL).

Als gevolg van de grote technologische vooruitgang in de gezondheidszorg worden in toenemende mate gegevens verzameld tijdens de uitvoering van klinische onderzoeken.

Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

The coursework within the Science Communication and Society (SCS) specialisation prepares students for internships and a career in communication about science and health.

Persoonlijke briefjes uit middeleeuws Rusland? We kennen wel veel officiële en kerkelijke documenten, maar de vondsten van stukjes beschreven berkenbast uit Novgorod geven op een unieke wijze inzicht in hoe 'gewone' mensen dagelijks met elkaar communiceerden.

The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics. This promotion has been awarded the predicate cum laude.

Cardiovascular diseases are the primary cause of death in the world with atherosclerosis as primary underlying cause.

The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.

Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: L.H. Heitman

CONCLUSION: This study demonstrates that human macrophages can be induced to exert direct anti-tumor activity against osteosarcoma cells. Our observation that the induction of macrophage anti-tumor activity by L-MTP-PE required IFN-gamma may be of relevance for the optimization of L-MTP-PE therapy in…

Het Gorlaeus Gebouw wordt in drie fasen gerealiseerd. Het nieuwe gebouw is medio 2028 helemaal gereed.

In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang

Tuberculosis is a major global health problem caused by the Mycobacterium tuberculosis complex, claiming more than a million lives annually.

Promotor: A.P. IJzerman

Promotores: A.P. IJzerman, H.W.T. van Vlijmen

Promotores: Prof.dr. J. A. Bouwstra, Prof.dr. W. Jiskoot

The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.

Promotor: B. van de Water

In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).

Promotor: Prof.dr. M. Danhof, Co-promotor: O.E. Della Pasqua

Nanoparticles can be used as delivery systems for both small molecules and macromolecules such as proteins, peptides or oligonucleotides. This thesis focuses on the use of liposomes, nanometric vesicles formed by a lipid bilayer enclosing an aqueous core. Liposomes are highly versatile delivery syst…

Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.

To improve cancer treatments, personalized medicine approaches have aimed to identify exactly which mutations are driving tumor development in a given patient and specifically target these mutations using precision therapies.

Promotores: W. Jiskoot, F. Ossendorp

The intradermal administration route is attractive for vaccine delivery, because of the highly populated antigen-presenting cells in the skin. However, the skin’s main physical barrier, the stratum corneum, prevents vaccines from entering the skin.

Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen

The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…

Over several decades, a variety of computational methods for drug discovery have been proposed and applied in practice. With the accumulation of data and the development of machine learning methods, computational drug design methods have gradually shifted to a new paradigm, i.e. deep learning methods…

Promotor: F.J. van Lunteren, E. Jorin

Promotor: A.P. IJzerman

Promotor: A.P. IJzerman Co-promotor: L.H. Heitman

Promotie

Moritz Jesse has been awarded a Jean Monnet Chair by the European Commission. In his MIND-EU Project he will focus on a coherent way to teach Migration, Integration, and Non-Discrimination at Leiden Law School at bachelor and master level.

In 2024 hebben medewerkers en studenten van de Universiteit Leiden veel mooie prijzen gewonnen en belangrijke onderzoekssubsidies binnengehaald.

In januari van dit jaar deden dr. Min Jung Cho en dr. Annie Trevenen-Jones van het Leiden University College in Den Haag een aanvraag voor een subsidie van het LUF - SVM (Stichting Verpakking en Milieu). In juni 2020 werd dit verzoek gehonoreerd en ontvingen zij een subsidie van € 75.000,-.

LUC The Hague biedt een driejarige bacheloropleiding aan in Liberal Arts & Sciences. Deze brede en uitdagende bacheloropleiding wordt volledig in het Engels gegeven, en heeft als centraal thema ‘Global Challenges’: grote uitdagingen waar de wereld en mensheid voor staat.

Dit was het programma van De Kennisboomgaard 2025:

Op deze pagina vindt u het overzicht van zowel de aankomende als de afgeronde alumniwebinars/masterclasses van de Universiteit Leiden. Bij elk afgerond webinar/masterclass vindt u de link naar de opname.