In this thesis, we show how MRFM can usefully contribute to the field of condensed-matter.

Promotores: Prof.dr. H. van Veen & Prof.dr. W. de Boer (Wageningen University)

The effective treatment of tuberculosis (TB) remains a major challenge to global health.

Increasing the efficiency of gene targeting (GT) as a genome editing tool in plants has been an important goal in plant biotechnology.

Promotor: T. Schmidt, Co-promotor: S. J.T. van Noort

Prematurely born neonates require, amongst others, pharmaceutical therapy. Dosing guidelines for these therapies are often based on data from term born neonates or older infants, while these are not necessarily similar to prematurely born neonates.

Promotores: J. Jonkers, K.E. de Visser

During embryonic growth, cells proliferate, differentiate, and collectively migrate to form different tissues at the right position and time in the body.

Lysosomal acid glucosylceramidase (GBA1) is a lysosomal enzyme that degrades glucolipids with its main substrate being glucosylceramide (GlcCer). Defects in the GBA1 gene lead to glycosphingolipidosis Gaucher disease (GD), in which the hydrolysis of GlcCer is impaired and therefore, it accumulates in…

This thesis seeks to combine two different research topics; Multi-Objective Optimization and Complex Network Analysis.

During my PhD research, I studied the photon statistics of light emitted by a microcavity that contains a single quantum dot (QD) on resonance.

Promotores: J.A.van Veen, P.L.G.Klinkhamer. Co-promotor: E.E.Kuramae

Freshwater is an important resource, but at a great risk of species decline due to habitat loss, pollution and over-exploitation, and invasive alien species.

Promotor: Christoph U. Keller, Co-promotores: Matthew A. Kenworthy, Frans Snik

Promotor: Prof.dr. M. Danhof

Until the 1990s, the only known planets were those in our Solar System. Three decades later, several thousand exoplanets have been discovered orbiting stars other than the Sun, and substantial efforts have been made to explore these strange new worlds through spectroscopic analyses of their atmosphe…

Promotor: Prof.dr. J. Kuiper

Promotor: J.A. Bouwstra Co-promotor: A. El Ghalbzouri

The work described in this dissertation contributes to a better mechanistic understanding of nanoparticles in vivo. To achieve that goal, we used the zebrafish as a highly predictive pre-screening model of nanoparticles.

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman

As leading cause of death worldwide, cancer is responsible for nearly 10 million deaths in 2020 according to World Health Organization (WHO). Cisplatin and its derivatives are commonly used chemotherapy agents for current cancer treatment in the clinics.

The focus of the described research in this thesis is on the oxidative stress response (Nrf2 pathway). The aim of the research presented in this thesis is to obtain more information concerning microRNAs which are involved in the Nrf2 pathway, to determine and evaluate the application of microRNAs for…

Marine sponges are important members of reef ecosystems, as they play ecological roles that are essential for the health of the reef.

Although nanoparticles are extensively used in various applications like consumer products and have most probably entered the environment, little is known about the effects of these particles on living organisms.

Inflammatory skin diseases such as psoriasis and atopic dermatitis can severely impact both the physical and social aspect of a patient’s life. Aberrant inflammatory responses are thought to be a major causative factor in these disorders, but an abundance of different factors contribute to the development…

Assessing the risks of engineered nanomaterials (ENMs) solely on the basis of experimental assays is time-consuming, resource intensive, and constrained by ethical considerations (such as the principles of the 3Rs of animal testing). The adoption of computational toxicology in this field is a high p…

Electron microscopy has become an extremely important techniquein a wide variety of elds.

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

Science is typically a patchwork of research contributions without much coordination. Especially in clinical trials, the follow-up studies that we do fail to be the most promising.

This thesis focuses on the X-ray spectral analysis of merging galaxy clusters and the plasma code development for future high-resolution X-ray spectroscopy observations.

Het doel van het RAISE Onderzoek is om te onderzoeken hoe veerkrachtige mensen omgaan met stress. We kijken specifiek naar hoe belangrijke biologische systemen, zoals de HPA-as en het immuunsysteem, samenwerken met de hersenen en de sociale omgeving om veerkrachtig functioneren na moeilijkheden in de…

This thesis explores how electron paramagnetic resonance (EPR) spectroscopy can be used to investigate key biochemical processes.

The ultimate goal of cosmologists is to find a cosmological model able to explain the current observational data.

Hot astrophysical plasma is ubiquitous in the Universe, from comets in our Solar system to the largest scale structures -- the cosmic web filaments. These hot plasmas, with the temperature of a few millions of degrees, are often observed in the X-ray wavelength range.

The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.

This Thesis focuses on the design and synthesis of ADP-ribosylated compounds that can be applied in biological studies.

In today's volatile market environments, companies must be able to continuously innovate. In this context, innovation does not only refer to the development of new products or business models but often also affects the entire organization, which has to transform its structures, processes, and ways of…

Promotores: T.H. Oosterkamp, N. de Jonge

The way organisms develop from the initial single-cellular state to a complex final assembly like the human body, and how the final body is maintained throughout life, is one of the greatest mysteries and it’s understanding one of the biggest scientific challenges.

Promotores: H.A. Udo de Haes, H.H.T. Prins, Co-promotor: H.H. de Iongh

Biological cells, the basic building blocks of all life forms, are surrounded by a lipid membrane. More than half of the membrane is occupied by membrane proteins, which can regulate the cell functionality through specific arrangements.

Bevorderen van AutoML-systemen gericht op machine learning-taken op basis van aardobservatie datasets.

Promotie

Reinforcement learning, agents en classificatie: dit zijn slechts enkele van de onderwerpen die onderzoekers op de BNAIC/BeneLearn-conferentie 2020 hebben besproken. Het was de eerste keer dat de Universiteit Leiden als gastheer optrad voor de jaarlijkse Belgisch Nederlandse Kunstmatige Intelligentie…

De meeste Learning My Way-modules hebben een vergelijkbare structuur: voorbereiding, seminar, integratie.

Gamic Learning in East Asian Studies - Wat kunnen spellen ons vertellen over de manier waarop mensen leren?