De progressie van menselijke ziekten als kanker en TBC is goed te bestuderen in larven van zebravissen. Met robots en automatische herkenning van microscopische beelden gaan bioloog Herman Spaink en informaticus Fons Verbeek uitzonderlijk snel het effect van nieuwe medicijnen testen. De aanschaf van…

Hoe kunnen we onze maatschappij zo inrichten dat de wereld leefbaar blijft voor onszelf en al het andere leven om ons heen? Aan dat vraagstuk werken Leidse wetenschappers samen vanuit allerlei disciplines, van biologie tot datawetenschap en van milieueconomie tot archeologie.

De onderzoeksgroep Business, Technology & Public Policy van de afdeling Bedrijfswetenschappen van Universiteit leiden houdt zich bezig met het onderzoeken van de dynamische wisselwerking tussen ‘nieuwe’ technologieën en de verschillende belanghebbenden die hiermee interacteren, waaronder consumenten,…

Om goed onderbouwde besluiten over complexe onderwerpen zoals het klimaat, recht en gezondheid te kunnen nemen, zijn wetenschappelijke resultaten van groot belang. Maar wetenschappelijke resultaten bevatten altijd een mate van onzekerheid. Binnen het onderzoek Communicatie over onzekerheden wordt onderzocht…

Endothelial dysfunction and microvascular diseases are key drivers of cardiovascular disease, the world's leading cause of death.

Promotor: D. Bouwmeester, Co-promotor: D. Kraft

Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros

Thermodynamics is one of the founding scientific pillars that has helped us better understand heat engines, biology, ecosystems, and even black holes. While it fundamentally describes large systems by examining the bulk behavior of their constituents, it is anchored in the statistical equivalence of…

This Thesis focuses on the design and synthesis of ADP-ribosylated compounds that can be applied in biological studies.

Chemical-induced organ toxicity is a major concern in the development and use of chemicals, including drugs, pesticides, industrial chemicals and cosmetics. In the last decades, the onset and progression of chemical-induced organ toxicity has been linked amongst others to perturbation of mitochondri…

The specialisation Science Communication and Society (SCS) concerns science communication in a broad sense. The program focuses on the link between science and society and covers knowledge and skills in the field of science communication.

Electron microscopy has become an extremely important techniquein a wide variety of elds.

Single-molecule spectroscopy has become a powerful method for using organic fluorescent molecules in numerous applications.

Promotores: W. Th. F. den Hollander, M.O. Heydenreich

Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez

Na het afronden van de bacheloropleiding volgen verreweg de meeste studenten de masteropleiding. De Universiteit Leiden stimuleert studenten om na hun bacheloropleiding door te gaan met de masteropleiding.

PNEC-pro is a user-friendly screening tool for professionals dealing with the assessment of surface water quality. The tool calculates local, watertype specific no-effect concentrations (PNEC) of copper, lead, nickel and zinc based on biotic ligand models (BLMs).

Streptomyces bacteria are a valuable source of natural products, many of which are used in the clinic or in biotechnology.

The research of the Applied Mathematics cluster is concerned with such diverse topics as dynamical systems, representation theory, differential equations and pattern recognition.

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Lezing

This thesis addresses the challenge of sustainable urban development by analyzing the interplay between green and grey infrastructure to optimize resource use and ecosystem services.

Viral hemorrhagic fever (VHF) is a group of acute diseases caused by highly infectious viruses including Ebola, Lassa, Dengue viruses. Its high mortality rate poses high risk to public health, however, studies on VHF have been hampered due to the non-availability of proper models and incomplete knowledge…

The mycorrhizal symbiosis is among the most widespread species interactions on Earth⁠. This thesis focuses on orchid mycorrhiza, a unique mycorrhizal type that has caught scientists’ attention for centuries⁠.

Wij richten ons op natuurlijke producten van onderzoek, de traditionele geneeskunde, etnobotanie en fytochemie.

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. M. van der Zee

This thesis describes the use of bioorthogonal proteins in immunological settings. It provides an introduction towards the field of protein modification, which was used throughout the thesis for the expression of proteins containing unnatural amino acids.

This thesis describes the design and synthesis of fragments of various cell wall carbohydrates of the Streptococcus species, including the branched Group B-specific antigen (GBC) of Group B Streptococcus, glycerol phosphate (GroP) modified group A carbohydrate (GAC), and the O-acetylated type 1 capsular…

Cardiovascular diseases (CVDs) are the leading global cause of mortality. Endothelial dysfunction, an early reversible stage of CVD development, is marked by decreased nitric oxide production linked to Ca2+ influx in endothelial cells.

Plastics have become an integral part of modern society due to their versatility and durability.

This thesis explores how electron paramagnetic resonance (EPR) spectroscopy can be used to investigate key biochemical processes.

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Bij zebravinken kunnen alleen de mannetjes zingen. Toch zijn het de vrouwtjes die de geluiden het snelst leren onderscheiden. Dat schrijven Leidse onderzoekers in het wetenschappelijk tijdschrift Animal Behaviour.

Archeologie is ook graven met hulp van de computer. Dat digitaal speuren naar hoe wij als mensen in het verleden leefden is wat Karsten Lambers het liefst doet. Hij is de eerste hoogleraar Digital and Computational Archaeology van ons land. ‘Een droom die uitkomt.’

Hoe detecteren bacteriën signalen uit hun omgeving en hoe passen ze zich daaraan aan? Die vraag intrigeert Ariane Briegel, hoogleraar Ultrastructuurbiologie. Met behulp van nieuwe technieken produceert ze driedimensionale beelden, die nieuwe informatie geven over het zintuiglijke systeem van bacteri…

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The study of orchid flowers, fruits, and inflorescences is crucial due to the remarkable diversity of orchid species and their unique adaptations to pollinators and seed dispersers. However, our understanding of the evolution and development of these organs within the orchid family remains limited.

Streptomyces are bacteria abundant in soil that participate in diverse and complex interactions. These bacteria are the main producers of the antibiotics we currently use in the clinic.