1,270 zoekresultaten voor “drug” in de Publieke website
-
Genomic driven treatment and drug rediscovery in patients with advanced cancer
Promotie
-
Nanoparticle-based combination drug delivery systems for effective cancer treatment
Promotie
-
Preclinical validation and mechanistic understanding of drug repurposing candidates for polycystic kidney disease
Promotie
-
Advancing cardiac safety and drug discovery screening using human stem cell-derived cardiomyocytes
Promotie
-
Gel-based drug delivery for safe and effective cancer immunotherapy
Promotie
-
of cortical, nerve, and muscle excitability in early phase clinical drug development
Promotie
-
Remco van den BroekWiskunde en Natuurwetenschappen
r.l.van.den.broek@lacdr.leidenuniv.nl | +31 71 527 2727
-
Majlen DilwegWiskunde en Natuurwetenschappen
m.a.dilweg@lacdr.leidenuniv.nl | 071 5272727
-
Willem JespersWiskunde en Natuurwetenschappen
w.jespers@lacdr.leidenuniv.nl | 071 5272727
-
Nasi LiuWiskunde en Natuurwetenschappen
n.s.liu@lacdr.leidenuniv.nl | 071 5276225
-
Myrtille KoerselmanWiskunde en Natuurwetenschappen
m.e.koerselman@lacdr.leidenuniv.nl | +31 71 527 6270
-
Leo PriceWiskunde en Natuurwetenschappen
lsprice@lacdr.leidenuniv.nl | +31 71 527 2727
-
Jingming LiuWiskunde en Natuurwetenschappen
j.liu@lacdr.leidenuniv.nl | +31 71 527 2727
-
Zoran GavricWiskunde en Natuurwetenschappen
z.gavric@lacdr.leidenuniv.nl | 06 43828286
-
Giulia CallegaroWiskunde en Natuurwetenschappen
g.callegaro@lacdr.leidenuniv.nl | 071 5276105
-
Marjolijn LugthartWiskunde en Natuurwetenschappen
m.j.l.lugthart@lacdr.leidenuniv.nl | +31 71 527 6270
-
Bert Beerkensb.l.h.beerkens@lacdr.leidenuniv.nl | 000 0000000
-
Dario BijkerWiskunde en Natuurwetenschappen
d.i.bijker@lacdr.leidenuniv.nl | +31 71 527 2727
-
Hugo van KesselWiskunde en Natuurwetenschappen
h.w.van.kessel@lacdr.leidenuniv.nl | 071 5272727
-
Lucina-May NollenWiskunde en Natuurwetenschappen
l.nollen@lacdr.leidenuniv.nl | +31 71 527 2727
-
Marc Boef
Wiskunde en Natuurwetenschappen
m.a.boef@lacdr.leidenuniv.nl | +31 71 527 2727
-
Cristina Serra I Melendez
Wiskunde en Natuurwetenschappen
c.serra.i.melendez@lacdr.leidenuniv.nl | 071 5272727
-
Het ontstekingsremmende effect van het PRG4-eiwit: reumatoïde artritis verlichten en voorkomen
Kan het eiwit PRG4 helpen om de symptomen van reumatoïde artritis te voorkomen of te verlichten?
-
Medicijnen op maat
Er komen steeds meer medicijnen die op specifieke kenmerken van een tumor gericht zijn. De toepassing van chemotherapie wordt nog steeds verbeterd.
-
Dementie voorspellen
In de toekomst kan een arts dementie wellicht veel eerder herkennen dan nu het geval is. Een computeralgoritme kan dan op basis van hersenscans voorspellen hoe ons geheugen zich gaat ontwikkelen.
-
Olivier BéquignonWiskunde en Natuurwetenschappen
o.j.m.bequignon@lacdr.leidenuniv.nl | 071 5272727
-
Chemical tools to study lipid signaling
Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.
-
Stress-induced modulation of the innate immune system in cardiovascular disease
Promotor: Prof.dr. J. Kuiper
-
Systems diagnosis in chronic disease: prediction and evaluation
Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen
-
Towards automated identification of metabolites using mass spectral trees
Promotor: Prof.dr. T. Hankemeier, Co-promotor: Theo Reijmers
-
Mast cells in advanced atherosclerosis: from human plaque stability to new therapeutic targets
In this thesis, the role of mast cells in atherosclerosis and novel therapeutic strategies to inhibit atherosclerosis progression are discussed. The first part of the thesis specifically focuses on the relation between mast cells and advanced human atherosclerotic plaque characteristics.
-
Dyslipidemia at the crossroad of the skin barrier and the arterial wall
The research described in this thesis shows that hypercholesterolemia, a well-established risk factor for atherosclerosis, can impact skin lipid pool and barrier function already at young age. In the field of atherosclerosis, we showed that the small peptide Lyp-1 can be used as a targeting molecule…
-
Mass Spectrometry-Based Degradomics Analysis of Toxoid Vaccines
The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.
-
Development of a healthy and diseased artery-on-a-chip
Cardiovascular diseases are a leading cause of death worldwide, and better models are urgently needed for disease progression studies and drug development.
-
Supercritical carbon dioxide spray drying for the production of stable dried protein formulations
Promotor: W. Jiskoot, Co-promotor: H.A. Every
-
Human skin equivalents for atopic dermatitis: investigating the role of filaggrin in the skin barrier
Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: A. El Ghalbzouri
-
Characterization of age-associated immunity in atherosclerosis
Healthy aging is one of the prime goals in today's society and atherosclerosis is among the greatest causes of morbidity in elderly. Cardiovascular disease patients receiving treatment are often of advanced aged and have an aged immune system, which limits translating experimental findings to the pa…
-
Evolvability and epistasis studied through the lens of an antibiotic resistance enzyme
Enzymes are innately sensitive to changes in the amino acid sequence, which largely constrains their evolutionary potential, i.e., evolvability. This evolutionary burden can be alleviated in the presence of stabilizing mutations, which increase the buffering capacity of enzymes to tolerate mutations…
-
Mast cells as immune regulators in atherosclerosis
Cardiovascular syndromes are the major cause of death in Western societies.
-
Geneesmiddelenonderzoek
In de onderzoekslijn Geneesmiddelenonderzoek werken we voornamelijk met knaagdieren. Knaagdieren, zoals muizen, worden veel gebruikt als proefdier. Deze kleine zoogdieren zijn makkelijk te houden en planten zich snel voort.
-
Protein arginine methyltransferases as modulators of lipid metabolism and inflammation and the relevance for atherosclerosis
Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…
-
Omics data integration with genome-scale modelling of dopaminergic neuronal metabolism
Parkinson's disease is the second most common neurodegenerative disease in the world. One of its symptoms is the loss of dopaminergic neurons in the substantia nigra pars compacta.
-
The role of the interleukin 12 family in atherosclerosis
Promotor: Johan Kuiper, Co-promotor: Saskia C.A. de Jager
-
Systematic investigations into the role of ceramide subclass composition on lipid organization and skin barrier
The lipids in the uppermost layer of the skin, the stratum corneum (SC), play an important role in the skin barrier function. The three main SC lipid classes are ceramides (CER), cholesterol and free fatty acids.
-
Virus-host metabolic interactions: using metabolomics to probe oxidative stress, inflammation and systemic immunity
Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken
-
Developmental effects of polystyrene nanoparticles in the chicken embryo
There is concern about the threat that nanoplastics (NPs) may pose to both wildlife and humans. This thesis explores the mechanisms of toxicity of polystyrene nanoparticles (PS-NPs) in chicken embryo.
-
Single-electrolyte isotachophoresis: on-chip analyte focusing and separation
Promotor: Thomas Hankemeier, Co-promotores: Heiko van der Linden, Paul Vulto
-
Exploring the chemical space of natural products from Streptomyces using multi-omics approaches
The increasing resistance of pathogenic bacteria to antibiotics necessitates the discovery of new medicines.
-
High-throughput profiling of small molecules using mass spectrometry
Promotor: Prof.dr. T. Hankemeier
-
Selective autophagy in host defense against mycobacterial infection
The effective treatment of tuberculosis (TB) remains a major challenge to global health.