In this thesis, we focus on novel proteins/mechanisms that regulate integrin-adhesion mediated mechano-transduction.

Promotor: W. Jiskoot, Co-promotor: A. Kros

This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion.

Promotor: Prof.dr. G.P. van Wezel

Promotor: B. van de Water, Co-promotor: E.H.J. Danen

Patients share valuable advice and experiences with their peers in online patient discussion groups.

Het Platform for Arts Research in Collaboration (PARC) is een nieuw online en offline platform voor onderzoekers die werkzaam zijn op het gebied van compositie, muziek, kunst en design en daarbuiten, om kennis, ervaringen en openbare evenementen uit te wisselen, samenwerking te stimuleren en de zichtbaarheid…

Dit onderzoek vindt plaats binnen de context van een vernieuwing in het Nederlandse biologieonderwijs. De belangrijkste doelstellingen van het onderzoek zijn (1) verhelderen hoe de praktijkkennis van docenten gerelateerd is aan de beslissingen die zij nemen wanneer zij lessen ontwerpen en uitvoeren…

Per 1 november is Laura Heitman benoemd tot hoogleraar Moleculaire farmacologie bij het Leiden Academic Centre for Drug Research (LACDR). Heitman draagt bij aan de ontdekking van nieuwe geneesmiddelen door onderzoek naar de interactie tussen medicijnen en hun aangrijppunt in het lichaam. ’Mijn uiteindelijke…

Op 8 juli 2020 verdedigde Andres Sarmiento Lamus zijn proefschrift 'The Proliferation of Dissenting Opinions in International Law'. Het promotieonderzoek is begeleid door promotoren prof.dr. L.J. van den Herik en prof.dr. Y.A.A.S. Radi (UCLouvain).

This thesis aims to demonstrate how the achromatic nature and design flexibility of liquid-crystal optics can be used to improve high-contrast imaging instruments to facilitate detailed exoplanet characterization.

In the Schouwburgstraat, LUGO is currently redesigning the back-garden in order to increase biodiversity and make it a more beautiful space. Throughout October 2023 until March 2024, we will be making changes to the garden with our team of volunteers.

Glycoconjugate vaccines are composed of microbial poly- or oligosaccharides covalently linked to a carrier protein.

Synthetic hydrogels that mimic the natural extracellular matrix in the biophysical and biochemical cues it provides to cells are in high demand, however the cell phenotypes as they are observed in vivo in numerous cases have yet to be attained.

The development process of any software has become extremely important not just in the IT industry, but in almost every business or domain of research.

Bio-farmaceuten kunnen vanaf nu modelcodes en datasets uit een databank opvragen om de dosering en het effect van nieuwe medicijnen beter te kunnen voorspellen.

Laura Heitman van het Leiden Academic Centre for Drug Research (LACDR) is genomineerd voor de Prix Galien Research Award. Deze belangrijke farmaceutische prijs bekroont jonge, vooraanstaande onderzoekers wiens wetenschappelijk onderzoek van grote betekenis is voor fundamenteel of klinisch geneesmidd…

Internist- klinisch farmacoloog Teun van Gelder is per 1 december 2019 benoemd tot Leidse hoogleraar Drug Discovery & Development. Hij zal zich bezighouden met het ontwikkelen van geneesmiddelen binnen de academische wereld, ook wel Academic Pharma genoemd.

M.T.M. Koper, Co-promotor: D.G.H. Hetterscheid

Sphingolipids are important membrane compounds with a variety of functions. In mammalian cells, different enzymes are involved in the metabolism of sphingolipids, but interruption of this metabolism process leads to different diseases.

Het onderzoek binnen COI@Leiden is geclusterd rond twee thema's: duurzame rechtspraak en de rechtszaal als maatschappelijke arena. Lees meer over elk van deze projecten door op de onderstaande links te klikken.

This thesis deals with the use of sound in interactions in the context of participatory systems and data sonification. We investigate an interactive environment where participants perceive information of the data through sound elements.

Gamic Learning in East Asian Studies - Wat kunnen spellen ons vertellen over de manier waarop mensen leren?

Promotor: H.J.M. de Groot

Bekijk de toelatingseisen voor de MSc Nederlandse Politiek aan Universiteit Leiden: vereiste bacheloropleiding, academische credits en taalvaardigheidseisen.

Current therapies for patients with atherosclerosis are targeted primarily on reducing blood cholesterol, but this fails to prevent a large number of cardiovascular events.95 In order to identify new therapeutic strategies for treating atherosclerosis, it is important to study the interactions between…

In this thesis, we describe the potential of cell mechanical phenotyping for immune cell characterization, diagnosis, drug testing, as well as treatment of disease.

Het doel van het onderzoeksprogramma Systems Pharmacology ligt in de ontwikkeling van strategieën voor gepersonaliseerde geneesmiddelen en de ontwikkeling van nieuwe systeemgebaseerde benaderingen in de translationele en klinische farmacologie.

Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel

The stratum corneum is the outermost skin layer and consists of dead cells embedded in a lipid matrix.

Promotor: Prof.dr. M.K. Richardson

Promotor: T. Hankemeier, Co-Promotores: T. Reijmers, L. Coulier

The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.

New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.

Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik

The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.

Source: Structure , Volume 22, Issue 8, pp. 1120-1139 (2014)

Promotor: Prof.dr. B. van de Water

Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood.

Epithelial-mesenchymal plasticity (EMP) and tumor cell migration play an important role in cancer progression, and an improved understanding of the mechanisms underlying these concepts is essential for developing new targeted approaches.

Viral hemorrhagic fever (VHF) is a group of acute diseases caused by highly infectious viruses including Ebola, Lassa, Dengue viruses. Its high mortality rate poses high risk to public health, however, studies on VHF have been hampered due to the non-availability of proper models and incomplete knowledge…

There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.

Traditionally, vaccines are administered intramuscularly using conventional hypodermic needles, which cause pain and distress. Microneedles are very short needles (smaller than 1 mm) that are practically invisible to the naked eye.

Childhood obesity is an increasing health issue. In the first part of this thesis comorbidities in children with obesity were studied, concerning the diagnostic process and dosing regimens.

Promotores: B. van de Water; P. Hogendoorn; J. Bovée Co-Promotor: E.H.J. Danen

Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…

Promotor: Prof.dr. M. Danhof

In summary, the collective results described in this thesis show that nanoparticulate vaccines can be delivered intradermally by coated and hollow microneedles and evoke antigen-specific immune responses.