The goal of this thesis is to understand how interfacial parameters, such as the addition of organic additives, bulk pH or metal cations of the electrolyte, affect the relevant electrocatalytic reactions, i.e. electrochemical CO2 reduction reaction or hydrogen evolution reaction.

Light-Harvesting Complex II (LHCII) is responsible for light absorption and excitation energy transfer in plants and photosynthetic algae, while in high light it undergoes conformational changes by which it quenches excitations to prevent photodamage.

Promotor: G. A. van der Marel, Co-promotor: D. V. Filippov

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-Promotor: J.D.C. Codee

Carbohydrates are present on the surface of bacteria making them suitable antigen candidates for vaccine development. This thesis deals with the synthesis of two carbohydrate-based components; the capsular polisaccharide of S. aureus type 5 and teichoic acids from staphilococci and enterococci speci…

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

Promotor: Prof.dr. H.J.M. de Groot, Co-promotor: Francesco Buda

Voor de omzetting van zonlicht naar brandstof

Photocatalysis has emerged as a powerful tool for enabling challenging transformations in organic synthesis. This thesis explores the development of several photocatalytic reactions designed to form carbon-heteroatom bonds from less-functionalized precursors.

This thesis describes the design, synthesis, and immunological evaluation of varying (neo)antigenic peptide conjugates containing either a TLR2 or a TLR7 agonist.

Overkleeft

Promotor: Prof.dr. G.A. van der Marel, Co-Promotor: J.D.C. Codée

The inverse electron demand Diels-Alder (IEDDA) pyridazine elimination emerged in 2013 as a new bioorthogonal reaction and constitutes a prime example of what is now known as dissociative bioorthogonal chemistry. The research described in this Thesis aims to develop synthetic strategies which enable…

This thesis describes the use of an activity-based proteomics method to study the endocannabinoid system.

The primary goal of this research is to deepen our understanding of substrate-enzyme interactions in Glycoside hydrolases. For this purpose, Bacillus circulans xylanase (BcX) has been selected as a well-established model to examine the Michaelis complex and glycosyl-enzyme adduct.

De Universiteit Leiden heeft een nieuw interdisciplinair studieprogramma gelanceerd: Urban Studies. Studenten duiken in dit Engelstalige bachelorprogramma in hedendaagse en toekomstige stedenproblematiek. Het is de eerste studie waarvoor vijf faculteiten de handen ineenslaan.

De bachelor Security Studies heeft een bronzen medaille ontvangen in EW Beste studies 2023. Elk jaar selecteert EW Beste Studies topopleidingen.

Pharmaceutical companies, governments and the general public have become increasingly aware that animal models used in drug testing lack vital aspects to serve as an accurate representation of human biology. As models of the human body should become more physiologically relevant, animal models no longer…

To meet the rising demand for minerals driven by the global shift to clean energy technologies, ensuring responsible and resilient supply chains is critical. Minerals like cobalt, lithium, and nickel for batteries, neodymium and zinc for wind turbines, and indium for solar panels are essential.

The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.

Op woensdag 31 augustus 2022 vond de diploma-uitreiking plaats van de BSc Security Studies. De ceremonie werd geopend door programmadirecteur Daan Weggemans.

Promotor: Prof.dr. T. Schmidt, Co-Promotor: S.J.T. van Noort

Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).

Striga hermonthica, commonly known as witchweed, infests major cereal crops in Sub-Saharan Africa causing severe yield losses and threatening the livelihood of millions of resource poor farmers.

Waar komen International Studies alumni terecht na hun afstuderen? Maak kennis met Guido, Paulien en Lennart. Zij deden alle drie de bachelor International Studies aan de Universiteit Leiden in Den Haag en zijn na hun studie in heel verschillende sectoren terechtgekomen.

Beneficial plant-associated microbiota, particularly those inhabiting the rhizosphere, contribute substantially to plant health through pathogen suppression, stimulation of plant defence responses, and enhanced nutrient acquisition.

Programma directeur van het bachelorprogramma Security Studies Daan Weggemans trapte vanmiddag het eerste webinar voor studiekiezers af. In Kaltura Live had hij een internationaal publiek van zo’n 60 geïnteresseerden.

The adsorption of D2 and CO2 on catalyst surfaces is studied using a molecular beam in ultra-high vacuum.

Promotor: Prof.dr. M. Ubbink, Co-promotor: G. Siegal

In this thesis, two potential therapeutic targets for diabetic nephropathy were dentified and investigated. First, we show that glomerular clusterin is upregulated in diabetic nephropathy and demonstrated that recombinant clusterin protein can protect the podocytes against oxidative stress in vitro.…

Promotor: Promotor: W.Th.F. den Hollander, Co-promotor: V. Sidoravicius.

De Nederlandse krijgsmacht is de afgelopen jaren op vele fronten veranderd. Letterlijk en figuurlijk. Deze uitgave brengt de laatste kennis en inzichten over het functioneren van dit belangrijke instituut bijeen. Een handboek voor praktijk, wetenschap en onderwijs.

The electrochemical hydrogenation reaction is an alternative approach for the transformation of unsaturated bonds without the use of flammable dihydrogen gas.

Op vrijdag 29 augustus 2025 ontvingen 370 studenten hun bachelordiploma International Studies. De diploma's werden uitgereikt in de historische ambiance van de Pieterskerk in Leiden. Familieleden, vrienden en medewerkers waren toegestroomd om deze heuglijke gebeurtenis met de afgestudeerden te vieren…

Lezing

Op vrijdag 11 december 2020 vond het eindejaarsseminar van Empirical Legal Studies plaats, uiteraard geheel coronaproof online. Via dit seminar konden collega’s en andere geïnteresseerden op een laagdrempelige manier meer te weten komen over het toepassen van empirische onderzoeksmethoden in de rec…

Ana Oleart kwam van Barcelona naar Den Haag voor haar bachelor International Studies. Na maar liefst twee masters aan de Universiteit Leiden werkt ze nu op de HR-afdeling van een grote hotelketen.

Promotor: H.J.M. de Groot

On Monday 26 August, students were warmly welcomed at the Wijnhaven location with a blue carpet and live music. Accompanied by their friends and family, they gathered to receive their BSc Security Studies diploma.

‘Religie is overal’ – dat is de eerste zin uit de missie van het nieuwe Leiden University Centre for the Study of Religion (LUCSoR). Na intensieve voorbereiding en in nauwe samenwerking met het Leiden University Institute for Area Studies (LIAS), is LUCSoR vandaag van start gegaan. Dit nieuwe centrum…

Decentralized plug and play systems for energy production are the future picture of our society. Artificial photosynthetic systems are used for this purpose.

Promotor: G.A. van der Marel, Co-promotor: D.C. Codée

Carbonaceous asteroids preserve a record of early solar system processes, where minerals and organic molecules, like polycyclic aromatic hydrocarbons (PAHs), offer clues to planetary evolution and prebiotic chemistry.

Vinasse is a major by-product generated by the sugarcane biofuel industry. It is a source of microbes, nutrients and organic matter and often it is recycled as fertilizer.

Single-molecule spectroscopy has become a powerful method for using organic fluorescent molecules in numerous applications.

In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.

This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.

In the current global context, there is a pressing need to address sustainable energy supplies to safeguard our Planet and its ecosystems. The choices made by human society have a significant impact on genetic evolution and climate.