Onderzoeksgroepen in het Biological & Soft Matter onderzoeksprogramma ontrafelen de mechanismen in biologische processen en ontwikkelen nieuwe zachte materialen die geïnspireerd zijn door de natuur.

Leiden Institute of Advanced Computer Science (LIACS)

Tuberculosebacteriën en andere intracellulaire pathogenen gebruiken immuuncellen als paard van Troje om zich in hun gastheer te verspreiden. Annemarie Meijer, hoogleraar immunobiologie, vertelt hoe onderzoek naar mechanismen van aangeboren immuniteit in zebravissen helpt om nieuwe behandelingsmethoden…

Ook planten maken groeihormonen aan, en kennen een proces van veroudering. Het bestuderen van de genen en de mechanismen hierachter is nuttig voor gewasveredeling en landbouw, maar ook voor medisch onderzoek. Dat stelt Remko Offringa, hoogleraar Ontwikkelingsgenetica van Planten.

This thesis describes our search to identify and understand possible regulatory mechanisms of integrin α6β4 in cell-matrix adhesion and intracelular signaling.

This course explores international arbitration as one of the most common methods of international dispute settlement. You will gain an in-depth understanding of international arbitration through the analysis of its role as a mechanism of dispute settlement, its institutions, the fields of law it is…

Als eersten ter wereld hebben studenten van de Leidse master Computer Science les gehad in het programmeren van een quantumcomputer. ‘Hiermee zijn eindelijk de complexe levensechte problemen van de maatschappij op te lossen.’

Onderzoek naar quantumcomputers en islamitische goede doelen: twee Leidse wetenschappers krijgen een Consolidator Grant van de European Research Council.

The study of orchid flowers, fruits, and inflorescences is crucial due to the remarkable diversity of orchid species and their unique adaptations to pollinators and seed dispersers. However, our understanding of the evolution and development of these organs within the orchid family remains limited.

Nature, nurture and neural mechanisms of social emotion regulation in childhood

This dissertation is an experimental study of laser-generated, atmospheric pressure, transient toroidal helium plasmas.

As a contribution to the changing legislation and evolving societal attitudes concerning environmental issues, this project aims to enhance and manipulate the plants’ own natural defense mechanisms against western flower thrips (WFT).

The research presented in this thesis makes use of small molecules (as H2 , D2 and O2 ) on well-defined single crystal surfaces (flat Pt(111), flat Cu(211) and curved Pt(111)) to elucidate the role of surface structure and degrees of freedom in the reactant in specific surface reactions.

The electrochemical oxygen reduction reaction (ORR) is an essential half-reaction for the utilization of hydrogen as a sustainable fuel, via the conversion of hydrogen to electrons and protons facilitated by the ORR. In the most common fuel cells, the ORR is requires high loadings of non-abundant platinum…

Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.

Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater

In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar

To improve cancer treatments, personalized medicine approaches have aimed to identify exactly which mutations are driving tumor development in a given patient and specifically target these mutations using precision therapies.

In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.

Breeding for resistance becomes more and more important because we want to reduce the use of pesticides. A fast and cheap alternative can be to make use of morphological or chemical markers.

Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.

Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency

In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).

In analogy to mathematical proofs, the goal of a proof system is for a prover to convince a verifier of the correctness of a claim.

The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.

Promotor: Prof.dr. J.G.E.M. Fraaije, Co-promotor: A. Kros

Soil is a home for an unbelievable diversity and abundance of microbial life that is essential for supporting life on our planet.

Om de juiste klinische beslissingen te nemen of effectieve diagnostische testen en behandelingen te kunnen ontwikkelen, is het belangrijk om de onderliggende mechanismen van een aandoening of een bepaald gedrag te begrijpen.

As a virtually inexhaustible source, solar energy plays a major role in future global energy scenarios.

Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet

Op welke manieren hebben ontwikkeling van digitale technologieën invloed op de samenleving en de regulerings- en juridische kaders binnen de samenleving?

Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.

Breast cancer is the most common cancer in women worldwide. Metastasis, the process by which cancer cells spread to other parts of the body, makes treatments less effective. It is important to unravel the mechanism of metastasis.

Onderzoek aan het Leids Instituut voor Onderzoek in de Natuurkunde (LION) is fundamenteel en nieuwsgierigheids-gedreven. Al onze wetenschappers delen de wens om de kennis van de wereld om ons heen te vermeerderen, in een open, nieuwsgierige sfeer, waarin innovatieve ideeën ontstaan die toepassingen…

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M.T.M. Koper, Co-promotor: D.G.H. Hetterscheid

To design the ideal water oxidation catalyst, understanding of the catalytic mechanism and decomposition pathways is essential.

Promotor: H.S. Overkleeft, Co-Promotor: B.I. Florea

Promotor: J.W.M. Frenken Co-Promotor: R. Felici

Gamic Learning in East Asian Studies - Wat kunnen spellen ons vertellen over de manier waarop mensen leren?

In vitro disease models play a fundamental role in drug research. They enable the systemic identification and validation of disease mechanisms and the discovery of possible drug targets. However, more than often, drug candidates that are identified in vitro fail in the later clinical stages of drug…

Promotor: G.J.B. van Ommen

Multicellular giant algae Chara species have been widely used in physiological studies for decades.

Promotores: C.A.M.J.J. van den Hondel, V. Meyer, Co-promotor: A.F.J. Ram

With the rise of multi-drug resistant bacterial pathogens, the possibility of a post-antibiotic world is quickly becoming reality.

In dit artikel onderzoekt Valentina Carraro de relatie tussen overlappende VN-mensenrechteninstellingen, met name de verdragsorganen en de Universal Periodic Review (UPR).