De Universiteit Leiden heeft onderzoeksinstituten gevestigd in Leiden en Den Haag.

Zoeken naar best practices voor en nieuwe inzichten in professionele training en ontwikkeling van docenten.

Drug development critically depends on preclinical models that mimic human physiology, yet traditional two-dimensional cultures and animal models often lack predictive power.

Claire van den Helder en Orestes Kyrgiakis hebben de Pieter de la Court Penning 2021 gewonnen. De Pieter de la Court Penning is een initiatief van en voor studenten en wordt jaarlijks uitgereikt aan studenten die zich vrijwillig inzetten voor één van de Pieter de la Court onderwerpen. Claire van den…

Het Nederlandse ondernemingsrecht stond altijd bekend om zijn soepele karakter. Wil Nederland aantrekkelijk blijven als vestigingsland dan zal zij haar ondernemingsrecht op structurele wijze moeten innoveren en het ondernemerschap moeten faciliteren en bevorderen. Op 20 maart 2015 aanvaardt Niek Zaman…

Het Gorlaeus Gebouw wordt in drie fasen gerealiseerd. Het nieuwe gebouw is medio 2028 helemaal gereed.

Promotor: A.P. IJzerman Co-promotor: L.H. Heitman

Persoonlijke briefjes uit middeleeuws Rusland? We kennen wel veel officiële en kerkelijke documenten, maar de vondsten van stukjes beschreven berkenbast uit Novgorod geven op een unieke wijze inzicht in hoe 'gewone' mensen dagelijks met elkaar communiceerden.

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

The overarching clinical aim of this thesis was to improve pharmacological pain management by characterizing the pharmacodynamics of analgesics. This promotion has been awarded the predicate cum laude.

Cardiovascular diseases are the primary cause of death in the world with atherosclerosis as primary underlying cause.

Promotor: B. van de Water

Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.

Als gevolg van de grote technologische vooruitgang in de gezondheidszorg worden in toenemende mate gegevens verzameld tijdens de uitvoering van klinische onderzoeken.

Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: L.H. Heitman

CONCLUSION: This study demonstrates that human macrophages can be induced to exert direct anti-tumor activity against osteosarcoma cells. Our observation that the induction of macrophage anti-tumor activity by L-MTP-PE required IFN-gamma may be of relevance for the optimization of L-MTP-PE therapy in…

To improve cancer treatments, personalized medicine approaches have aimed to identify exactly which mutations are driving tumor development in a given patient and specifically target these mutations using precision therapies.

Als alumnus van de Universiteit Leiden kunt u uw hele leven lang gebruik blijven maken van de Universitaire Bibliotheken Leiden (UBL).

In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).

Promotor: Prof.dr. M. Danhof, Co-promotor: O.E. Della Pasqua

Nanoparticles can be used as delivery systems for both small molecules and macromolecules such as proteins, peptides or oligonucleotides. This thesis focuses on the use of liposomes, nanometric vesicles formed by a lipid bilayer enclosing an aqueous core. Liposomes are highly versatile delivery syst…

Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang

Tuberculosis is a major global health problem caused by the Mycobacterium tuberculosis complex, claiming more than a million lives annually.

The coursework within the Science Communication and Society (SCS) specialisation prepares students for internships and a career in communication about science and health.

Promotores: W. Jiskoot, F. Ossendorp

The intradermal administration route is attractive for vaccine delivery, because of the highly populated antigen-presenting cells in the skin. However, the skin’s main physical barrier, the stratum corneum, prevents vaccines from entering the skin.

The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.

Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.

In this thesis, mathematical modeling and simulation was applied as a tool to inform quantitative decision making in oncology drug discovery and development.

Over several decades, a variety of computational methods for drug discovery have been proposed and applied in practice. With the accumulation of data and the development of machine learning methods, computational drug design methods have gradually shifted to a new paradigm, i.e. deep learning methods…

Promotor: A.P. IJzerman

The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.

Promotor: A.P. IJzerman

Promotores: A.P. IJzerman, H.W.T. van Vlijmen

Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen

Promotores: Prof.dr. J. A. Bouwstra, Prof.dr. W. Jiskoot

The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…

Promotor: F.J. van Lunteren, E. Jorin

Moritz Jesse has been awarded a Jean Monnet Chair by the European Commission. In his MIND-EU Project he will focus on a coherent way to teach Migration, Integration, and Non-Discrimination at Leiden Law School at bachelor and master level.

In 2024 hebben medewerkers en studenten van de Universiteit Leiden veel mooie prijzen gewonnen en belangrijke onderzoekssubsidies binnengehaald.

We werken graag en veel samen met diverse partners: met andere kennisinstellingen, bedrijfsleven, overheid, maatschappelijke organisaties, ngo's, musea en goede doelen. Dichtbij, in onze steden Leiden en Den Haag, maar ook verder regionaal, landelijk en internationaal.

Via verschillende soorten sessies breng jij op vrijdag 28 november jouw inter- of transdisciplinaire werk een stap verder.

‘Wij gaan onderwijs opzetten rond de thema’s legal tech en juridisch ondernemerschap’, schetst de Leidse opleidingsdirecteur René Orij.