1,860 zoekresultaten voor “development disease” in de Publieke website
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Exploitation of host chemokine signalling by pathogenic mycobacteria
Promotores: A.H. Meijer, H.P. Spaink
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Learning from nature: using plant-soil feedback principles to improve growth and health of a horticultural crop
Plants and soils from natural ecosystems harbor great diversity of soil microorganisms, which could potentially contribute to the sustainability of horticulture. The knowledge about using wild plant species and soil from natural ecosystem to improve the crop health will advance the application of ecological…
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The endocannabinoid system in zebrafish larvae
In this thesis, we have studied the potential of the zebrafish larval model in studying the ECS, as a complementary model to the existing rodent models.
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Replacing the needle and syringe for vaccine administration
Promotores: Prof.dr. G.F.A Kersten, Prof dr. J.A. Bouwstra
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Vaccination and Targeted Therapy Using Liposomes; Opportunities for Treatment of Atherosclerosis and Cancer
This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.
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Parkinson’s protein α-synuclein: membrane interactions and fibril structure
The thesis describes the use of electron paramagnetic resonance (EPR) spectroscopy, in continuous wave and pulse modes, to address the interaction of α-Synuclein (αS) with membranes and the aggregation of αS.
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Functional analysis of agrobacterium tumefaciens virulence protein VirD5
Supervisor: P.J.J. Hooykaas
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Tools for real-time study of bioorthogonal conversions in the living system
Traditional biochemical methods for studying organelles require cell disruption, preventing the real-time observation of dynamic intracellular processes.
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Kernteam
Het kernteam van het PDC is verantwoordelijk voor onderzoek en ontwikkeling van de LMW-methode en voert het beheer van de LMW trajecten binnen de verschillende deelnemende instellingen.
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MicroSafari in Museum Boerhaave
Ga op MicroSafari in Museum Boerhaave en kom alles te weten over infectieziektes en over bacteriën waar antibiotica geen vat meer op hebben. Team Antibiotica Gezocht!, winnaar van de Academische Jaaprijs 2011, heeft een boeiende audiotour samengesteld.
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Iber Kasehatan in Sukamiskin: Utilisation of the Plural Health Information and Communication System in the Sunda Region of West Java, Indonesia
This study has been carried out in the community of Sukamiskin, a kelurahan (‘village’) in Bandung, the Capital of West Java Province, located in the Sunda Region of Indonesia.
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Onderzoekers
De wetenschappers van Babylab Leiden zorgen ervoor dat belangrijke kennis verzameld wordt over de wijze waarop baby's de wereld om hen heen leren begrijpen. Ontmoet ons Babylab Team en leer onze onderzoekers kennen!
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Photo-activation of ruthenium-decorated upconverting nanoparticles
Metal-based prodrugs based on ruthenium(II) polypyridyl complexes have proven to be very suitable for application in both photodynamic therapy (PDT) and photo-activated chemotherapy (PACT).
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SCS Courses
The coursework within the Science Communication and Society (SCS) specialisation prepares students for internships and a career in communication about science and health.
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Using insertional mutagenesis to identify breast cancer drivers and therapy resistance genes in mice
In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.
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Onderwijs
Culturele Antropologie en Ontwikkelingssociologie in Leiden staat bekend om haar internationaal georiënteerde expertise. Met een breed scala aan theoretische, methodologische en regionale onderwerpen, biedt de opleiding een sterk gefundeerd en verdiepend programma.
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Joost Visserj.m.w.visser@liacs.leidenuniv.nl | 071 5272727
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Vervolgopleidingen
Volg een Masteropleiding na het behalen van je Bachelor Pedagogische Wetenschappen.
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Macrophage cell models for the investigation of Gaucher disease
Promotie
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Clinical and patient reported outcomes in chronic kidney disease
Promotie
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Immunity against post-translationally modified proteins in autoimmune diseases
Promotie
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Refractory Celiac Disease: from basic insights to therapy
Promotie
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The endothelial compartment as a disease modifier in bleeding disorders
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Prevalence and burden of pain in Huntington's disease
Promotie
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Understanding Hypercoagulability: Determinants and Impact on Cardiometabolic Disease
Promotie
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Deep learning assisted image-based cardiovascular disease diagnosis
Promotie
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Circulating non-coding RNAs in kidney disease
Promotie
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Blueprints of Disease: Precision Platforms for Modelling Breast Cancer
Promotie
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Novel targets in the liver to treat cardiometabolic diseases
Promotie
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Hemolytic Disease of the Fetus and Newborn: Awareness Precedes Change
Promotie
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Preventive Cardiovascular Strategies For Patient With Advanced Kidney Disease
Promotie
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Advanced non-invasive diagnostics in congenital heart disease
Promotie
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About Time: Implications of Chronoactivity on Health and Disease
Promotie
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Generating epidemiological evidence for controlling emerging infectious disease outbreaks
Promotie
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From Dissonance to Symphony: Therapeutic Innovations in Parkinson’s Disease
Oratie
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Systems pharmacokinetic models to the prediction of local CNS drug concentrations in human
Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.
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First-pass and systemic metabolism of cytochrome P450 3A substrates in neonates, infants, and children
Growth and development affect the metabolism of drugs administered to neonates, infants, and children.
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High-throughput profiling of small molecules using mass spectrometry
Promotor: Prof.dr. T. Hankemeier
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Targeting Human Proteasomes: Substrates, Inhibitors and Prodrugs
Large parts of the research described in this Thesis aims at the development of oligopeptide-masked toxins and their in situ immunoproteasome-mediated activation.
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Sandra van Dijk helpt nierpatiënten gezonder te leven
Hoe kunnen nierpatiënten geholpen worden een gezonde leefstijl aan te nemen? Gezondheidspsycholoog Sandra van Dijk gaat dit onderzoeken met een persoonsgebonden subsidie van de Nierstichting.
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Aanpassen aan klimaatverandering: door mutatie kunnen meelkevers zich sneller ontwikkelen
Biologen vonden een mutatie in meelkevers die ervoor zorgt dat ze zich sneller ontwikkelen. Het onderzoek is gepubliceerd in Nature Ecology and Evolution.
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Lisa FennisBestuursbureau
l.v.fennis@bb.leidenuniv.nl | 06 28315095
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Naomi MeijnenBestuursbureau
n.meijnen@bb.leidenuniv.nl | 071 5272727
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Angelique RompelbergBestuursbureau
a.j.m.rompelberg@bb.leidenuniv.nl | 071 5273248
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Benoeming Judi Mesman: Hoogleraar Interdisciplinary study of societal challenges
Prof. dr. Judi Mesman is benoemd tot hoogleraar interdisciplinary study of societal challenges, een gedeelde leerstoel tussen de faculteiten Governance and Global Affairs (FGGA) en Sociale Wetenschappen (FSW) van de Universiteit Leiden.
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Synthesis of well-defined ADP-Ribosylated biomolecules
Promotor: G. A. van der Marel, Co-promotor: D. V. Filippov
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Crossing boundaries
Celebrating 20 years of environmental research in Cagayan Valley and Sierra Madre
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Evolutionary molecular dynamics
This thesis introduces the concept of
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Towards Photocatalytic Water Splitting in Homogeneous Solutions Using Molecular Metalloporphyrin Photosensitizers and Catalysts
Indonesia is experiencing various environmental challenges related to its fast economic growth. Therefore, it is necessary to have measurable and applicable indicators to obtain accurate data and information regarding the costs of adverse environmental impacts arising from economic activities to support…
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Prediction of spatial-temporal brain drug distribution with a novel mathematical model
A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.