Promotor: Johan Kuiper, Co-promotor: Saskia C.A. de Jager

Promotor: Thomas Hankemeier, Co-promotores: Heiko van der Linden, Paul Vulto

The increasing resistance of pathogenic bacteria to antibiotics necessitates the discovery of new medicines.

The effective treatment of tuberculosis (TB) remains a major challenge to global health.

Promotor: Prof.dr. T. Hankemeier

The spindle-assembly checkpoint (SAC) is a safety mechanism which secures accurate chromosome segregation during mitosis.

Promotor: J. Kuiper

Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.

We have studied the impact of particle shape anisotropy, multivalent interactions and flexibility on systems of micron-sized colloidal particles.

Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz

De Faculteit der Wiskunde en Natuurwetenschappen is gevestigd op verschillende locaties in het Bio Science Park Leiden.

The investigation into the bidirectional communication between the gut and its host is a rapidly growing area of research, attracting considerable attention for its potential to provide crucial insights into health and disease.

Promotors: C.A.J. Knibbe, Anthonius de Boer, Co-promotor: M.M.J. van der Vorst

Promotores: Wim Jiskoot; Ferry Ossendorp

The progressive loss and degeneration of dopaminergic neurons is a major pathological hallmark of Parkinson's disease (PD). The onset and progression of PD can be triggered by multiple risk factors, for instance, genetic mutation, environmental exposure, and aging.

The research described in this thesis shows that hypercholesterolemia, a well-established risk factor for atherosclerosis, can impact skin lipid pool and barrier function already at young age. In the field of atherosclerosis, we showed that the small peptide Lyp-1 can be used as a targeting molecule…

Uitgaansgeweld, seksueel geweld, huiselijk geweld…een samenleving zonder een vorm van gewelddadig gedrag is haast ondenkbaar. De wetenschap is dan ook al lange tijd bezig met geweld en geweldsbeheersing. Een belangrijk werkveld, maar het ontbrak aan een overzicht van wetenschappelijke en praktijkgerichte…

Promotor: T. Hankemeier, Co-promotor: T.H. Reijmers

Maakt microdoseren met LSD je echt creatiever? Is ayahuasca dé oplossing voor depressie en verslaving? Helpt MDMA om trauma's te verwerken? Kunnen psychedelica zelfs de wereld redden omdat we er spontaan klimaatbewuster van worden? Te midden van wat een psychedelische revival lijkt, doet neurowetenschapper…

Promotor: Prof.dr. T. Hankemeier, Prof.dr. J.C.T. Eijkel (Twente University)

Control of infectious diseases poses continuous challenges for human health.

Promotor: Prof.dr. B. van de Water

Promotor: Prof.dr. T. Hankemeier, Co-promotor: Theo Reijmers

Promotor: Prof.dr. J. Kuiper

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

Cell-based medicinal products (CBMPs), such as CAR T cells, are highly complex biopharmaceutical products offering various treatment options for serious illnesses such as cancer or autoimmune diseases.

Promotor: J.A. Bouwstra Co-promotor: A. El Ghalbzouri

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

In this thesis, the role of mast cells in atherosclerosis and novel therapeutic strategies to inhibit atherosclerosis progression are discussed. The first part of the thesis specifically focuses on the relation between mast cells and advanced human atherosclerotic plaque characteristics.

Promotores: Prof.dr. J. Kuiper, Prof.dr. P.H.A. Quax, Co-promotor: I. Bot

Filamentous Actinobacteria, such as Streptomyces, produce a plethora of chemically diverse bioactive metabolites that have found applications across medicine, agriculture and biotechnology.

Atherosclerosis is the main underlying pathology of cardiovascular disease. Atherosclerosis is caused by an immune response which is directed against (modified) lipoproteins which accumulate in the vessel wall.

Atherosclerosis is the most important underlying process that drives cardiovascular disease, and is characterized by an accumulation of cholesterol which triggers an inflammatory response in the vessel wall.

The last decades it is increasingly recognized that acute as well as chronic postoperative pain is an important problem. Treatment and prevention of postoperative pain is a challenge, especially in special patient populations where there is only limited guidance on how to optimally use opioids.

The goal of the research presented in this thesis was to explore the chemical space of ruthenium(II) photocages, investigate their ability to host potent chemotherapy drugs, and to red shift the activation wavelength of the most promising PACT candidates to conduct biological studies.

Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency

In dit project gebruiken we sociale netwerkanalyse om het gedrag van gebruikers op online fora en bijbehorende marktplaatsen in de tijd te analyseren.

This thesis describes the development of improved formulations and alternative delivery strategies for polio vaccination.

This thesis investigated miniaturized mass spectrometry (MS)-based analytical methods to address challenges in analyzing biomass-restricted biological samples.

Atherosclerosis is the most prominent underlying pathology of cardiovascular disease and an important cause of major adverse cardiovascular events.

The power of personalized nutrition lies in being able to conduct clinical research on healthy people while capturing metabolic markers sensitive to the impact of environmental and metabolic stressors (e.g. diet, changing sex hormones and the menstrual cycle).

De Universiteit Leiden heeft onderzoeksinstituten gevestigd in Leiden en Den Haag.