The main goal of the research described in this thesis was the development of new photoactivated chemotherapy (PACT) ruthenium(II) complexes bearing a non-toxic photolabile ligand.

Promotores: R. Cramer, A.K. Lenstra, Co-Promotor: B.M.M. de Weger

Catharanthus roseus (Madagascar periwinkle) produces valuable monoterpenoid indole alkaloids (MIAs) such as vincristine and vinblastine, crucial for cancer treatment.

Promotor: Ed F. Deprettere, Co-promotor: Todor P. Stefanov

Reducing greenhouse gas emissions is one of the most pressing challenges that humanity faces in the coming decades.

Promotor: Jelle S. Kaastra Co-promotor: Jelle de Plaa

Promotores: Prof.dr.G.R. de Snoo and Dr. R. Heijungs

Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik

Solute carrier (SLC) transporters are a large and diverse class of relatively understudied transmembrane proteins.

Promotores: Prof.dr. A.G.G.M. Tielens, Prof.dr. L. Kaper (UvA)

According to the amyloid cascade hypothesis, accumulation of beta-amyloid (Aβ) peptides initiates the pathological cascade in Alzheimer's disease (AD).

Ice, the solid state of water, plays an important role on our planet as well as the entire universe.Despite the fact that an individual water molecule has a very simple structure, its chemical bonding in the solid phase can be surprisingly complex.

The research described in this thesis focused on the use of bioorthogonal antigens to investigate immunological processes in antigen presenting cells. Bioorthogonal antigens are antigenic proteins produced through recombinant expression in a methionine auxotrophic E. coli strain.

Promotors: Prof.dr. G.R. de Snoo, Prof.dr. H. Leirs (Univ. Antwerpen)

Promotor: C.J. ten Cate

Catalysis is of extreme relevance in the production of everyday materials and plays a central role in many aspects of our life.

Promotores: Prof.dr. H. van Veen & Prof.dr. W. de Boer (Wageningen University)

Consequences for sediment stability and seston trapping

Large carnivores and humans, along with their livestock, have co-existed for thousands of years. However, human population growth and an increase in economic activities are modifying the landscape for large carnivores and their prey.

‘Wie meent rechts- en levensbeschouwing te kunnen scheiden, schaadt beide. Hij vervalst zijn rechtsovertuiging, omdat hij het teruggrijpen op de hoogste waarde stelselmatig vermijdt’, aldus Paul Scholten (1875-1946), één van de grootste, zo niet dé grootste rechtsfilosoof die de Lage Landen hebben v…

Promotores: Prof.dr. P.M. Brakefield, Prof.dr. B.J. Zwaan (Wageningen Universiteit)

Op 17 november 2021 verdedigde Cyril-Igor Grigorieff het proefschrift 'The Regime for International Air Carrier Liability'. Het promotieonderzoek is begeleid door prof.dr. P. Mendes de Leon en prof.dr. V. Correia (University Paris Saclay).

Op 8 november verdedigde Jordi Wiersma het proefschrift 'Democratie, deugden, docentschap: de docent als gids in de democratie'. Het promotieonderzoek is begeleid door Andreas Kinneging en Paul van Geest.

This dissertation studies the Asymptotics of Bayesian nonparametric inference for Gaussian linear models.

This thesis systematically analyzes the physical-chemistry of lipid-graphene interactions with the major objective of reconciliating the variety of results reported in the literature.

Large carnivore population is globally declining as a result of the fragmentation of habitat, large prey depletion and retaliatory killing by pastoralists.

Bicarbonate buffer is largely found in nature due to its ability to regulate pH variations around neutral values. As the pH changes, so does the speciation of the buffer.

Stochastic resetting is simple enough to be approached analytically, yet modifies stochastic processes in a non-trivial way.

Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez

Op een luchtige en frisse wijze worden serieuze onderwerpen besproken als: Wat is een experiment eigenlijk? En welke vragen kun je beter wel, of beter niet proberen te beantwoorden?

Acute cardiovascular clinical events such as myocardial infarction and cerebral stroke represent the major cause of death in Western societies. These pathologies are primarily resulting from atherosclerosis, a progressive condition characterized by the accumulation of lipids, immune cells, and fibrous…

Balsaminaceae is a diverse plant family characterized by a huge floral morphological diversity.

Promotores: B. van de Water; P. Hogendoorn; J. Bovée Co-Promotor: E.H.J. Danen

Op 17 december 2018 verdedigde Dejian Kong zijn proefschrift 'Civil Liability for Damage caused by Global Navigation Satellite System'. Het promotieonderzoek is begeleid door promotor prof. dr. P.M.J. Mendes de Leon.

Plants and their pollinators form complex interaction networks. Within these networks, species differ widely in the number of species they interact with.

Dit proefschrift onderzoekt de noodzaak van het creatief denken en experimenteren in het uitvoeren van complexe muziek in de late twintigste- en vroege eenentwintigste eeuw.

Every organisms in the tree of life faces the same challenge: the length of its DNA exceeds the volume of the cell it needs to fit in. Several strategies have evolved to solve this problem, one of them being the expression of proteins that bind and organize the DNA.

Promotor: W. Jiskoot, Co-promotor: H.A. Every

LCA has become an important method to study environmental impacts of human activities. Still, there are several methodological issues in LCA that can adversely affect the results reliability.

This dissertation consists of two parts, with the common theme

Promotor: F.H.J. Redig, Co-Promotor: W.T.F. den Hollander

This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.

Immunotherapies for cancer are an emerging class of therapeutic strategies which aim to treat cancer via augmentation of the immune system.

Promotores: J.N. Kok, H.J. Hoogeboom

Low-mass main-sequence stars like our Sun are continuous sources of outflowing hot magnetised plasma. In the case of the Sun, this is known as the solar wind, whereas for other stars they are called stellar winds.

Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken

To an algebraic curve C over the complex numbers one can associate a non-negative integer g, the genus, as a measure of its complexity.

My PhD thesis investigates the ecological significance of resistance against drought-induced air bubble formation inside the water conduits of plants (embolism), and the plasticity and functional aspects of stem anatomical traits in woody and herbaceous species.

Sound is everywhere in the marine environment and hearing is therefore a very important for stimuli for fish. They use sound for orientation and communication, during migration, aggregation and spawning, but also for detection of prey and predators.

Het Justice, Equity, Diversity and Inclusion (JEDI) Fund is een fonds dat financiële steun verschaft aan projecten en initiatieven die diversiteit en inclusie (D&I) promoten, waarbij een specifieke nadruk ligt op het creëren van een inclusieve leeromgeving.