Promotor: J. Kuiper

In this thesis, I targeted the orchid genus Lepanthes, one of the six genera of angiosperms that surpasses 1,000 species in the Neotropics, as a study model to investigate the evolutionary processes that promoted species diversifications.

Promotores: T.H. Oosterkamp, N. de Jonge

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

Promotor: E. Gittenberger, Co-promotores: L.P. van Ofwegen; B.W. Hoeksema

Streptomyces are prolific producers of enzymes and secondary metabolites, including more than 50% of all clinical antibiotics. This makes them highly attractive for medical, biotechnological, and industrial purposes.

This proposed research uses ego-documents from visual artists that were not intended for publication to reassess the scholarly debate on the demise of the Russian Avant-garde aesthetic in the twenties and early thirties of the 20th century.

Promotor: C.A.J. Knibbe, Co-promotores: H.P.A. van Dongen, B. van Ramshorst

In some condensed matter systems, such as the surface of a 3D topological insulator, the electrons are effectively massless and we must necessarily use the massless Dirac equation to describe them.

With the advent of multicore processors and data centers, computer hardware has become increasingly parallel, allowing one to run multiple pieces of software at the same time on different machines. Coordination of these pieces is best expressed in a coordination language as an explicit interaction protocol…

In this thesis we explore machine and deep learning approaches that address keychallenges in high dimensional problem areas and also in improving accuracy in wellknown problems. In high dimensional contexts, we have focused on computational fluid dynamics (CFD) simulations.

Marine sponges are important members of reef ecosystems, as they play ecological roles that are essential for the health of the reef.

Promotor: R. Tijdeman, Co-promotor: H.J.J. te Riele

In this thesis we study bistable reaction-diffusion equations on lattice domains.

My PhD project studies how the temporally sequential Hox gene expression is regulated during head-tail patterning of the frog embryo.

This thesis describes the genetic and prokaryotic diversity of giant barrel sponges.

Promotor: Prof.dr. M.L. van Heck, Co-Promotor: B.P. Tighe

Promotor: S.M. Verduyn Lunel, Co-promotores: M.F.E. de Jeu, B. de Pagter

To address the fundamental questions of how life on Earth emerged and how common life may be in the Universe, it is crucial to know the chemical composition of the planet-forming material.

The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.

Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.

Promotie

The thesis describes terrestrial field trials aimed to detect side-effects of pesticides within the framework of pesticide registration procedures. Field trials were developed using vascular plants Brassica napus and Poa annua, caterpillars Pieris brassicae and effects on decomposition were studied…

Promotor: S.J. Edixhoven Co-promotor: L. van Geemen, P. Parent

Promotor: Prof.dr. H.J.M. de Groot, Co-promotor: Francesco Buda

The main object of study in this thesis is an Arakelov inequalitywhich bounds the degree of an invertible subsheaf of the direct image ofthe pluricanonical relative sheaf of a semistable family of curves.

Given the accelerating appearance of antimicrobial resistance, there is an urgent need for more fundamental research into novel antibiotic strategies. The work in this thesis helps to address this global problem by developing new antibiotic compounds, inspired by the antibacterial mechanisms of the…

There is an increasing amount of attention on EU and its Member States contributions to implementation of two landmark agreements: the Paris Climate Agreement and the UN Agenda 2030 with Sustainable Development Goals (SDGs). Absent from the current literature is an analysis of the political effect of…

Almost all bacteria are enveloped by a cell wall that provides cellular protection.

Errors are everywhere, and mechanical failures are especially common: buckled grain silos and cracked support columns are, justly, seen as an issue to be avoided.

This thesis explored the molecular pharmacological mechanisms of targeting CB2R via investigation of novel drug discovery concepts such as target binding kinetics, allosteric modulation and biased signaling.

Promotores: P. Stevenhagen, L. van Geemen Co-promotor: R.M. van Luijk

The main focus of this thesis is the behaviour of two-dimensional materials, namely (anti)-ferromagnetic materials in the first two chapters, which show topological phases, and energetic square ice in the third and fourth chapter.

The application of nanomaterials in industrial processes and consumer products provides many societal benefits, but can also lead to the release of nanomaterials into the environment. The work in this dissertation aims to provide insights into the potential environmental impacts that may follow from…

This thesis focuses on data found in the field of computational drug discovery. New insight can be obtained by applying machine learning in various ways and in a variety of domains. Two studies delved into the application of proteochemometrics (PCM), a machine learning technique that can be used to…

Aan de opleidingen van het Centre for Professional Learning op het gebied van Terrorisme, Recht en Veiligheid zijn verschillende (research) fellows verbonden. De fellows geven advies over de inhoud van het curriculum en de verbinding tussen wetenschap en praktijk.

In dit artikel wordt onderzocht hoe educatieve risicocommunicatie de openbare veiligheid kan ondersteunen tijdens nucleaire noodsituaties.

De auteurs analyseren twee belangrijke factoren die informaliteit verdiepen, namelijk multipolaire geopolitiek en de opkomst van niet-statelijke actoren.

Constant Hijzen, universitair docent aan het Institute of Security and Global Affairs (ISGA), sprak in het NRC over de Wet op de inlichtingen- en veiligheidsdiensten. In de column ‘Twistgesprek’ van het NRC voert Hijzen een schriftelijk gesprek met de directeur van Bits for Freedom, Hans de Zwart, over…

Vind jouw thuis bij LUC! Wij zijn gevestigd in het hart van Den Haag. Met ons eigen gebouw en internationale profiel biedt LUC een omgeving voor iedereen die op zoek is naar een interculturele ervaring en die een verantwoordelijke wereldburger wil worden.

Public Administration is a major refereed journal publishing articles on public administration, public policy and public management.

Op 5 en 6 november 2019 wordt in Den Haag door het The Hague Program for Cyber Norms een conferentie georganiseerd met als thema: ‘Dealing with Uncertainty’

Bij sommige jongeren met suïcidale gedachten en gedragingen is er een subtiel maar significant verschil in de hersenstructuur, zo blijkt uit onderzoek. 'Het resultaat vertelt wellicht meer over de mechanismen bij suïcidaal gedrag in een specifieke subgroep', zeggen postdoctoraal onderzoeker Laura van…

In deep reinforcement learning, searching and learning techniques are two important components. They can be used independently and in combination to deal with different problems in AI, and have achieved impressive results in game playing and robotics. These results have inspired research into artificial…

How can we broaden youth participation in STEM Learning

Workshop

Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.

Promotor: Prof.dr. T. Schmidt, Co-Promotor: S.J.T. van Noort