Afstudeerceremonie

Welke hersencel doet wát als bijvoorbeeld de ziekte van Parkinson ontstaat? Het duurt niet lang meer voordat die puzzel stukje voor stukje gelegd kan worden. Computationeel bioloog Ahmed Mahfouz combineert Leidse bio-kennis met Delftse algoritmen en komt steeds dichterbij de sleutel.

In this thesis we construct an extension associated with the Furstenberg compactification of symmetric space of noncompact type. From this extension we get a cycle in equivariant KK-theory representing the extension. The construction of the extension and the corresponding cycle is a generalization of…

De faculteit vindt ‘P-in-1’ iets om trots op te zijn en staat daar graag bij stil. Op donderdag 16 oktober kregen 295 studenten hun Propedeusediploma’s uitgereikt, onder toeziend oog van familie en vrienden. De studenten hebben hun Propedeuse allemaal in één jaar gehaald. Een prachtige prestatie.

Technologische ontwikkelingen gaan snel. Het Leiden Legal Technologies Programme stond op de agenda van de Adviescommissie tijdens de tweede bijeenkomst op 15 oktober. Het besluit om het programma in januari 2021 te starten is unaniem genomen. Het was het officiële moment om de afronding van de voorbereidingen…

Het Leiden Centre of Data Science (LCDS) is in Den Haag druk bezig met het ontwikkelen van een multidisciplinaire opleiding Legal Technologies in nauwe samenwerking met het Centre for Professional Learning (CPL). Zij werken hierbij samen met drie faculteiten van de Universiteit Leiden, namelijk de Faculteit…

Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.

Lipid formulations have demonstrated strong potential for nucleic acid delivery,particularly with the success of COVID-19 vaccines. Despite these advances, manyaspects of lipid formulations remain unclear.

Promotores: H. Schiessel, G.T. Barkema

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

Promotor: A. Kros

In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.

This thesis describes the development and optimization of the first molecular tools to study the enzyme PLA2G4E.

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea

The main goal of the research described in this thesis was the development of new photoactivated chemotherapy (PACT) ruthenium(II) complexes bearing a non-toxic photolabile ligand.

Promotor: T. Schmidt

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

Promotor: P.G.L. Klinkhamer, Co-Promotores: K. Vrieling, P.P.J. Mulder

Source: Structure , Volume 22, Issue 8, pp. 1120-1139 (2014)

Promotor: G.P. van Wezel, Co-Promotor: E. Vijgenboom

In most applications, electrocatalysts exhibit a large surface area to volume ratio, for example using nanoparticles.

Promotor: Prof.dr. B. van de Water

Chemical-induced organ toxicity is a major concern in the development and use of chemicals, including drugs, pesticides, industrial chemicals and cosmetics. In the last decades, the onset and progression of chemical-induced organ toxicity has been linked amongst others to perturbation of mitochondri…

Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.

Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. M. van der Zee

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman

Promotores: J. Jonkers, K.E. de Visser

Promotor: Prof.dr. B. van de Water

Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez

Pectin is a plant cell wall polysaccharide made of mainly D-galacturonic acid (GA) subunits. The potency of the filamentous fungus Aspergillus niger to naturally secrete high amounts of pectinases to degrade pectin has been utilized for the industrial production of pectinases.

All life on earth contains DNA, which is used to store biological information. Organisms compact their DNA in order for it to fit inside their cell(s).

Cancer is considered the silent pandemic of the 21st century and the second leading cause of death worldwide.

G protein-coupled receptors (GPCRs), one of the largest families of membrane proteins, are responsive to a diverse set of physiological endogenous ligands including hormones and neurotransmitters.

This thesis describes the synthesis and biological evaluation of TLR2/6, TLR4, TLR7/8 and TLR9 ligands, of which the activity can be conditionally controlled.

Cardiovascular disease is the leading cause of death worldwide.

Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.

The work described in this dissertation contributes to a better mechanistic understanding of nanoparticles in vivo. To achieve that goal, we used the zebrafish as a highly predictive pre-screening model of nanoparticles.

Promotor: P. J. J. Hooykaas, Co-promotor: R. Offringa

Antibiotic resistance, caused by widespread use of antibiotics, leads to bacterial infections that are difficult, if not impossible, to treat and is a major worldwide health concern.

The focus of the described research in this thesis is on the oxidative stress response (Nrf2 pathway). The aim of the research presented in this thesis is to obtain more information concerning microRNAs which are involved in the Nrf2 pathway, to determine and evaluate the application of microRNAs for…

Promotor: Jaap Brouwer, Co-promotor: Remus Th. Dame

Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.

This thesis describes the use of bioorthogonal proteins in immunological settings. It provides an introduction towards the field of protein modification, which was used throughout the thesis for the expression of proteins containing unnatural amino acids.

This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.

The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.

Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz

Promotor: A. Kros, Co-promotor: R.R.C.L. Olsthoorn

Drug-induced liver injury (DILI) is one of the main reasons for drug attrition during pre-clinical and clinical phases of drug development as well as for drug withdrawal post-marketing.

Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis