1,682 zoekresultaten voor “war on drug” in de Publieke website
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Hybrid conference on animation in the Middle Ages
From 16 to 19 September 2021 a hybrid conference will take place on animation in the Middle Ages. This conference is a cooperation between the University of Bergen (Norway) and the A. Zelwerowicz National Academy of Dramatic Art in Warsaw, Branch Campus in Bialystok (Poland).
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Alexander KrosFaculteit der Wiskunde en Natuurwetenschappen
a.kros@chem.leidenuniv.nl | 071 5274234
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Shaping the pharmacokinetic landscape for renally cleared antibiotics in obesity
The prevalence of obesity (BMI >40 kg/m2) has increased rapidly over the recent years, not only in adults, but also in children and adolescents.
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Summer School on the History of the Book
Van 21 augustus tot en met 8 september zijn de workshops en cursus van de jaarlijkse Summer School on the History of the Book van het Allard Pierson en de vakgroep Boekwetenschap. Drie weken lang is er elke werkdag een cursus, workshop of lezing over thema’s die te maken hebben met de geschiedenis van…
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systems: A comparison of security by design and privacy by design based on a systematic literature review
De auteurs zoeken en beoordelen systematisch relevante definities van Security by Design (SbD) in vergelijking met Privacy by Design (PbD).
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win land conflicts for corporations: Legal Strategy and its influence on the Rule of Law in Indonesia
Op 23 juni 2020 verdedigde Santy Kouwagam haar proefschrift 'How lawyers win land conflicts for corporations: Legal Strategy and its influence on the Rule of Law in Indonesia'. Het promotieonderzoek is begeleid door promotoren prof.dr. A.W. Bedner en prof.dr. C.E. von Benda-Beckmann.
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Limited Impact of Introducing Proportional Representation on Women’s Representation: Insights from a Quasi-Experiment in Local Elections
Dit artikel onderzoekt de effecten van de invoering van proportionele vertegenwoordiging (PR) op de politieke vertegenwoordiging van vrouwen.
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This is life: some thoughts on self-organized structure formation in active liquids and biological systems
It has been a long-standing mystery how complex biological structures emerge from such seemingly uncoordinated building blocks as cells and tissues, in the presence of only minimal environmental guidance.
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On hard real-time scheduling of cyclo-static dataflow and its application in system-level design
Promoter: Ed F. Deprettere, Co-promoter: Todor P. Stefanov
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Designing 'context-specific' regional innovation policy: a study on the role of regional government in six European regions
Whilst government’s ability to design ‘context-specific’ regional innovation policy is generally assumed to depend on the region’s decision-making power, the aim of this study is to investigate how regional government matters. In order to open up the black box of policy design, the study develops a…
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intelligence with insights from complexity science and field research on NATO
Hoe kan complexiteitswetenschap de transformatie van inlichtingen bevorderen?
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Analyzing sequences of confrontational maneuvering in Dutch plenary debates on EU issues
Op 4 juni promoveert Isabella Steenbergen. Het Leiden University Centre for Linguistics feliciteert Isabella!
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microbes: disentangling the effect of soil biotic and abiotic characteristics on trees using soil inoculation
In this thesis I examine how soil biotic and abiotic characteristics change and interact throughout the course of afforestation and how they subsequently impact tree performance.
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Freezing conditions in warm disks: snowlines and their effect on the chemical structure of planet-forming disks
This thesis focusses on the temperature structure in protoplanetary disks. The relation between structures seen in the dust and gas-phase molecules is investigated.
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Enhancing tourists’ safety abroad. A literature review on best practices to support risk and crisis communication in tourism and hospitality
Wouter Jong en Hanne Goossen onderzoeken de werkwijzen op het gebied van risico- en crisiscommunicatie binnen de toeristische sector.
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To wind up changed: Assessing the value of social conflict on onshore wind energy in transforming institutions in the Netherlands
In dit artikel onderzochten Annemiek de Looze en Eefje Cuppen empirisch of en hoe sociaal conflict leidt tot institutionele verandering.
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The United Nations Convention on the Rights of the Child Taking Stock after 25 Years and Looking Ahead
Het boek 'The United Nations Convention on the Rights of the Child' is het resultaat van de conferentie – ’25 Years CRC’ – die in november 2014 in Leiden werd gehouden.
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Knowledge development of secondary school L1 teachers on concept-context rich education in an action-research setting
In deze studie wordt verslag gedaan van een onderzoek naar de ontwikkeling van de praktijkkennis bij elf docenten Nederlands. Zij ontwikkelden en implementeerden concept-contextrijk onderwijs met behulp van actieonderzoek.
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On the nature of the right to resist: a rights-based theory of the ius resistendi in liberal democracies
Op 7 september verdedigde Francesc Claret Traid het proefschrift 'On the nature of the right to resist: a rights-based theory of the ius resistendi in liberal democracies'. Het promotieonderzoek is begeleid door Afshin Ellian en Gelijn Molier.
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Conceptualisation of the Rule of Law in its External Relations: Case Studies on Development Cooperation and Enlargement
Op 26 juni 2019 verdedigde Lisa Louwerse haar proefschrift 'The EU’s Conceptualisation of the Rule of Law in its External Relations: Case Studies on Development Cooperation and Enlargement'. Het promotieonderzoek is begeleid door promotor prof. mr. C.A.P. Hillion.
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Transdisciplinary Perspectives on Validity: Bridging the Gap Between Design and Implementation for Technology-Enhanced Learning Systems
Technologies that help to enhance our educational environments can be found everywhere.
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Plastic, Not Always Fantastic: Nano- and microplastics and their impact on terrestrial plants and the food chain
Plastics have become an integral part of modern society due to their versatility and durability.
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An uncertain recovery: The physical toll of COVID-19 infection on liberal arts and sciences students in the Netherlands
Josien de Klerk en Tennessee Miller onderzochten de interactie tussen de ziekte- en herstelervaringen van studenten en de academische werkcultuur in deze context.
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Towards better L1-oral language education: perspectives on good quality oral language teaching and the role of feedback
Hoewel spreekvaardigheidonderwijs internationaal wordt beschouwd als essentieel voor het bevorderen van communicatieve vaardigheden en kritisch denken, is dit domein aanzienlijk minder onderzocht dan lees- en schrijfvaardigheid. Dit onderzoeksproject had als overkoepelend doel zicht te krijgen op werkende…
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Perspectives on the World 2015-2016 uitgebracht
De faculteit Geesteswetenschappen staat bekend om de diversiteit van verschillende onderzoeksvelden die allemaal bijzonder en spraakmakend onderzoek verrichten. In de nieuwe uitgave van Perspectives on the World: Education and research within the Faculty of Humanities lichten studenten en wetenschappers…
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Early Dutch Radio Astronomy (1940-1970)
Promotores: F.H. van Lunteren, F.P. Israel
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Corpora Non Agunt Nisi Fixata: Ligand Receptor Binding Kinetics in G Protein-Coupled Receptors
The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.
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Mesoporous silica nanoparticle-based protein delivery systems for biomedical applications
Promotor: A. Kros
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Visualization of Vitamin A Metabolism
Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.
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In vitro and in vivo delivery of functionalized nanoparticles via coiled-coil interactions
Promotor: A. Kros, Co-promotor: R.R.C.L. Olsthoorn
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Leiden Complex Networks Network day on 23 September
On Friday 23 September 2016 the Leiden Complex Networks Network day, the LCN2 day, will take place in Leiden.
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Efficiënte chemie voor nieuwe antibiotica tegen C. difficile
Hoe kunnen we efficiënte chemische synthese en klinische microbiologie combineren om nieuwe antibiotica tegen Clostridioides difficile-infecties te ontwikkelen?
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Small changes for long term impact: optimization of structure kinetic properties: a case of CCR2 antagonists
Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: L.H. Heitman
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Using insertional mutagenesis to identify breast cancer drivers and therapy resistance genes in mice
In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.
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Concepts and applications for evidence-based dosing in morbidly obese patients before and after weight loss surgery
Promotor: C.A.J. Knibbe, Co-promotores: H.P.A. van Dongen, B. van Ramshorst
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Targeting the adenosinergic system
Adenosine is an endogenous ligand which exerts its action by activating adenosine receptors (ARs), while its circulating levels are controlled via a variety of mechanism and proteins, amongst others the equilibrative nucleoside transporters (ENTs).
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De vrijheid van expressie on trial: Houllebecq
Nathalie Schnabl, masterstudent Encyclopedie en Filosofie van het Recht, blikt in dit verslag terug op de lezing 'De vrijheid van expressie on trial' die door Paul Cliteur werd verzorgd in de lezingenreeks Recht en Literatuur 2016/2017
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Leiden University & Elsevier Symposium on Digital Sovereignty
Onze steeds toenemende afhankelijkheid van software en technologie, uit gemak, noodzaak of anderszins, maakt ons afhankelijk van de supranationale en commerciële bedrijven die deze producten leveren. Hoe belangrijk is het dat overheden, universiteiten en onderzoekers ervoor zorgen dat zij de controle…
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In vivo modelling of Ewing sarcoma in zebrafish
Promotores: Prof.dr. P.C.W. Hogendoorn & Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar-Jagalska
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Illuminating N-acylethanolamine biosynthesis with new chemical tools
In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.
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De bom (najaar 2020)
75 jaar na Hiroshima en Nagasaki In samenwerking met Japanmuseum SieboldHuis, naar aanleiding van de tentoonstelling aldaar.
- Robotic Liquid Handler
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Patient-derived models of breast cancer: a breakthrough story of the duct
To improve treatment of breast cancer patients it is important to understand all stages of breast cancer from initiation to in situ disease and progression to invasive disease. In this thesis we use intraductal injections of patient derived tissue to model ductal carcinoma in situ and invasive breast…
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Software
Image-Pro Plus, ImageJ, Cell Profiler, R, Knime en NIS-elements
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To affinity and beyond: novel molecular tools to explore solute carrier transport proteins
Despite being the second largest transmembrane protein family after GPCRs, the SLC superfamily has only gained significant attention in early drug development over the past decade.
- Verslaving: waarom kan je niet stoppen met...?
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Inhibitor Selectivity: Profiling and Prediction
Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.
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Allosteric modulation and ligand binding kinetics at the Kv11.1 channel
Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: L.H. Heitman
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Phenotypic screening with 3D cell-based assays
Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.
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Dosing considerations for preterm neonates: from pharmacometrics to clinical practice
Prematurely born neonates require, amongst others, pharmaceutical therapy. Dosing guidelines for these therapies are often based on data from term born neonates or older infants, while these are not necessarily similar to prematurely born neonates.