1,064 zoekresultaten voor “drug” in de Publieke website
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Hugo Minneeh.minnee@lacdr.leidenuniv.nl | 071 5274324
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Marc Boefm.a.boef@lacdr.leidenuniv.nl | 071 5272727
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Cristina Cristina Serra Melendezc.serra.i.melendez@lacdr.leidenuniv.nl | 071 5272727
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Nasi Liun.s.liu@lacdr.leidenuniv.nl | 071 5276225
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Kostas Tassisk.tassis@lacdr.leidenuniv.nl | 071 5276302
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Myrtille Koerselmanm.e.koerselman@lacdr.leidenuniv.nl | 071 5276270
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Leo Pricelsprice@lacdr.leidenuniv.nl | 071 5272727
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Jingming Liuj.liu@lacdr.leidenuniv.nl | 071 5272727
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Hugo van Kesselh.w.van.kessel@lacdr.leidenuniv.nl | 071 5272727
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Nada Badrn.badr@lacdr.leidenuniv.nl | 071 5272727
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Remco van den Broekr.l.van.den.broek@lacdr.leidenuniv.nl | 071 5272727
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Peter Bouwmanr.j.p.bouwman@lacdr.leidenuniv.nl | 071 5277166
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Marjolijn Lugthartm.j.l.lugthart@lacdr.leidenuniv.nl | 071 5276270
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Martijn Moném.j.mone@lacdr.leidenuniv.nl | 071 5276105
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Giulia Callegarog.callegaro@lacdr.leidenuniv.nl | 071 5276105
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Dario Bijkerd.i.bijker@lacdr.leidenuniv.nl | 071 5272727
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Olivier Béquignono.j.m.bequignon@lacdr.leidenuniv.nl | 071 5272727
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Ruim 700.000 euro voor de strijd tegen agressieve borstkanker
Eiwitten remmen die een rol spelen bij de groei van agressieve kankercellen, dat is het plan van professor Bob van de Water en zijn team. Zij ontvangen hiervoor ruim 700.000 euro van KWF Kankerbestrijding. Onderzoeker Maaike Vreeswijk en patholoog Danielle Cohen zijn aangesloten vanuit het LUMC.
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Bob van de Waterwater_b@lacdr.leidenuniv.nl | 071 5276223
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Photo-activation of ruthenium-decorated upconverting nanoparticles
Metal-based prodrugs based on ruthenium(II) polypyridyl complexes have proven to be very suitable for application in both photodynamic therapy (PDT) and photo-activated chemotherapy (PACT).
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Inhibitor discovery of phospholipases and N-acyltransferases
In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.
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Modulation of the immune system for treatment of atherosclerosis
Cardiovascular diseases are the primary cause of death in the world with atherosclerosis as primary underlying cause.
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Archief
Op deze pagina vindt u de opnames van de online This Week's Discoveries vanaf 12 mei 2020 en een lijst sprekers vanaf oktober 2015.
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Allosteric modulation by sodium ions and amilorides of G protein- coupled receptors
Promotor: A.P. IJzerman
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CE-MS for metabolomics: advancing performance and detection sensitivity
The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.
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Regulation of actomyosin contraction as a driving force of invasive lobular breast cancer
In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).
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Liposome-based vaccines for immune modulation: from antigen selection to nanoparticle design
Nanoparticles can be used as delivery systems for both small molecules and macromolecules such as proteins, peptides or oligonucleotides. This thesis focuses on the use of liposomes, nanometric vesicles formed by a lipid bilayer enclosing an aqueous core. Liposomes are highly versatile delivery syst…
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Studies on molecular basics of metabolic syndrome in zebrafish
The research described in this thesis has, using the zebrafish as a model system, shed new light on the intricate relationship between TB and DM2, in particular on the role of leptin, SHP-1 and glucocorticoids.
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Bioorthogonal Antigens as Tool for Investigation of Antigen Processing and Presentation
In order to be able to develop effective medicine and treatments to prevent or cure autoimmune diseases or cancer we need to understand the mechanisms how they arise and what drives their course.Unravelling the fundamental molecular mechanisms influencing the onset and course of diseases such as allergies,…
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Macrophages inhibit human osteosarcoma cell growth after activation with the bacterial cell wall derivative liposomal muramyl tripeptide in combination
CONCLUSION: This study demonstrates that human macrophages can be induced to exert direct anti-tumor activity against osteosarcoma cells. Our observation that the induction of macrophage anti-tumor activity by L-MTP-PE required IFN-gamma may be of relevance for the optimization of L-MTP-PE therapy in…
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Planning
Het Gorlaeus Gebouw wordt in drie fasen gerealiseerd. Het nieuwe gebouw is medio 2028 helemaal gereed.
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Photothermal studies of single molecules and gold nanoparticles: vapor nanobubbles and conjugated polymers
Promotor: M.A.G.J. Orrit
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Cholesterol metabolism in mouse models of atherosclerosis and adrenal steroidogenesis
Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.
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Systems diagnosis of chronic diseases, explored by metabolomics and ultra-weak photon emission
Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang
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Using mouse models to uncover genes driving tumorigenesis and therapy resistance in human breast cancer
To improve cancer treatments, personalized medicine approaches have aimed to identify exactly which mutations are driving tumor development in a given patient and specifically target these mutations using precision therapies.
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Nanoparticles and Microfluidics for Future Tuberculosis Vaccines
Tuberculosis is a major global health problem caused by the Mycobacterium tuberculosis complex, claiming more than a million lives annually.
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Lipid bilayers decorated with photosensitive ruthenium complexes
Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet
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Metabolomics Insights into the Gut Microbiome and Infants with Cow’s Milk Allergy
The rapid expansion of research on human gut microbiome in recent decades has highlighted its role in human metabolism, immune regulation, and behavior.
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Eregalerij 2024
In 2024 hebben medewerkers en studenten van de Universiteit Leiden veel mooie prijzen gewonnen en belangrijke onderzoekssubsidies binnengehaald.
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Eregalerij 2020
Ook in 2020 hebben veel van onze medewerkers en studenten mooie prijzen gewonnen en belangrijke onderzoekssubsidies binnengehaald.
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Antistoffen tegen reumatische ziektes direct getest in patiënten
Hans Ulrich Scherer, Leidse hoogleraar translationele reumatologie, staat met zijn ene been in de kliniek, waar hij patiënten helpt. Daarnaast begeleidt hij onderzoekers in het laboratorium. In zijn zoektocht naar reumatische auto-immuunziektes slaat hij een brug tussen beide werelden.
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Helle van den Maagdenbergh.w.van.den.maagdenberg@lacdr.leidenuniv.nl | 071 5272727
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Chenlin Fengc.l.feng@lacdr.leidenuniv.nl | 071 5272727
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Sylvia Le Dévédecs.e.ledevedec@lacdr.leidenuniv.nl | 071 5274285
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Roelof van der Kleijr.g.van.der.kleij@lacdr.leidenuniv.nl | 071 5277075
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Gerard van Westengerard@lacdr.leidenuniv.nl | 071 5273511
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Cecilia Bergonzinic.bergonzini@lacdr.leidenuniv.nl | 071 5274496
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host-directed therapy for Mycobacterium avium infection: identification of drug candidates and potential host targets
Promotie
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RARE-NL gaat op zoek naar behandelingen voor zeldzame ziekten
RARE-NL, een nieuw samenwerkingsverband van diverse universitaire ziekenhuizen, gaat op zoek naar behandelingen voor zeldzame ziekten. Namens het LUMC neemt hoogleraar Teun van Gelder deel aan het initiatief.
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Max Fernkornm.fernkorn@lacdr.leidenuniv.nl | 071 5272727