Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.

Dit proefschrift beschrijft een collectie aan alternatieve strategieën voor het begrijpen, ontwerpen en toepassen van lipide nanosystemen, waarin de rol van de bio-nano interacties centraal staan. In het bijzonder wordt gekeken naar de interactie van RNA-lipide nanosystemen, bekend van de toepassing…

This Thesis describes the design, synthesis and evaluation as glycoprocessing enzyme inhibitors of focused libraries of iminosugars.

This thesis focused on the exploration of monolayer graphene as a membrane in direct methanol fuel cell (DMFC) applications, with improvements achieved through plasma exposure or damage- free chemical functionalization.

This dissertation was to develop effective graphene-based nanofluidic devices by developing scalable fabrication methods and elucidating proton transport mechanisms.

This thesis comprises the development of reproducible synthesis procedures for two-dimensional materials (composed of boron, nitrogen and carbon) on different metallic surfaces.

This thesis introduces the concept of

Indonesia is experiencing various environmental challenges related to its fast economic growth. Therefore, it is necessary to have measurable and applicable indicators to obtain accurate data and information regarding the costs of adverse environmental impacts arising from economic activities to support…

A new type of tripodal squaramide-based supramolecular hydrogels is developed and studied.

The thesis focuses on synthesis strategies in oligosaccharide campaigns, and the influence of protecting groups.

Molecular complexes can be used as electrocatalysts for oxygen reduction, water oxidation, and/or hydrogen peroxide production.

Promotor: Prof.dr. M.T.M. Koper, Co-Promotor: F. Calle-Vallejo

In this thesis we have discussed several parameters that affect the electrochemical conversion of enviromentaly harmful molecules such as nitrates and carbon dioxide to more valuable and less deleterious compounds, in order to cast light onto the mechanism of the reaction to achieve an efficient and…

This doctoral thesis is an effort to understand how lipid phase-separation induced by diacylglycerol analogues in lipid-based nanoparticles affects their in vivo behavior, leading to specific nanoparticle-protein communications and selective cell targeting.

In eight chapters, the thesis of Rafaël Vos covers the effect of temperature and pressure on the electrochemical CO2 reduction.

Promotor: M.T.M. Koper, Co-Promotor: L.B.F. Juurlink

Promotor: M. Ubbink, Co-Promotor: R. T. Dame

De olympiades zijn jaarlijkse wedstrijden in (exacte) vakken waar alle scholieren in de bovenbouw van havo en vwo aan mee kunnen doen. De Universiteit Leiden werkt mee aan de volgende Olympiades:

The aim of this thesis is to develop and study a robust and adaptable scaffold for supramolecular polymer self-assembly in water.

The aim of this thesis is to explore the use of Bioorthogonal Antigens to study the cross-presentation pathway.

In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.

This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion.

Nature uses a special class of histone proteins, histone variants, to modulate the properties of chromatin at defined genomic locations.

The research presented in this thesis explores the chemotherapeutic potential of metal-based compounds as chemotherapy agents, with an initial focus on the synthesis and DNA interaction studies of platinum and palladium compounds utilizing the [Pt(bapbpy)]2+ scaffold. The study identifies intercalation…

BlaC is the β-lactamase of Mycobacterium tuberculosis. We show that it can recover from inhibition by clavulanic acid and that phosphate helps it do so.

Endocannabinoids are lipid messengers that modulate various physiological functions by activating the cannabinoid CB1 and CB2 receptors. While the metabolism of endocannabinoids and their action at the CB receptors is fairly well studied, the molecular mechanisms governing their release and transport…

The main goal of this thesis is to achieve advanced control of binding properties in bis-pyrrolic and macrocyclic pyrrolic receptors by light.

In this thesis, we consider various (electro)chemical phenomena at surfaces and nanoparticles and their underlying atomistic processes, which we studied using first-principles methods such as density functional theory.

The work in this thesis demonstrates how to obtain an atomic-scale picture of a diverse set of complex surface structures observed using STM, under disparate conditions.

This thesis focuses on the synthesis, characterization and performance towards CO2 electroreduction of mono and bi-metallic particles based on p-block metals

A structural investigation of coiled coil peptides used as membrane fusogens, mimicing naturally occuring coiled-coil fusion proteins. Synthetic modifications have been made to alter lipid attachment, secondary structure and to insert photoactive azobenzene moieties for active control over coiled coil…

Promotor: Prof.dr. J.P. Abrahams

Fundamental understanding of molecular reactions on metal surfaces is important for improving heterogeneous catalysis.

The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.

Promotor: Prof.dr. M. Ubbink

The research described in this thesis combines the latest insights in lysosomal function with lysosome centred cell signalling.

Na het afronden van de bacheloropleiding volgen verreweg de meeste studenten de masteropleiding. De Universiteit Leiden stimuleert studenten om na hun bacheloropleiding door te gaan met de masteropleiding.

Promotor: G. J. Kroes

Promotor: Prof.dr. M. Ubbink

This thesis advance our understanding and the application of molecular catalysts relevant to the reduction of oxygen as well as reduction of nitrite.

This work has described synthetic strategies towards well-defined structures resembling capsular polysaccharide (CPS) fragments, CPS mimics, teichoic acid (TA) fragments as well as a third-generation ring-closing tandem metathesis (RCM) linker to better exploit the potential of automated synthesis.

N-acylethanolamines (NAEs), including N-arachidonoylethanolamine (anandamide, AEA), N-palmitoylethanolamine (PEA) and N-oleoylethanolamine (OEA), are signaling lipids that play an important role in different physiological process.

This thesis explores squaramide-based supramolecular polymers and hydrogels, enhancing their mechanical strength for 3D cell culture.

This thesis investigates the relations between metabolism and anatomy through the use of Magnetic Resonance Imaging (MRI).

Het onderzoeksprogramma ’Towards Biosolar Cells’ krijgt van het kabinet een budget van 25 miljoen euro. Het ministerie van Landbouw, Natuur en Voedselkwaliteit (LNV) heeft het programma voorgedragen omdat het onderzoek een bijdrage gaat leveren aan duurzame energie, verbetering van de voedselvoorziening…

Kunstmatige bladeren, goedkope fotobiologische cellen. Dat zijn producten waarop BioSolar Cells zich met € 42 miljoen subsidie vijf jaar gaat richten. In BioSolar Cells werken 34 partijen, waaronder de Universiteit Leiden, samen in een klopjacht op de duurzame productie van bio-energie en voedsel door…

Een internationaal team van onderzoekers onder leiding van Alice Booth (Universiteit Leiden) heeft methanol ontdekt in het warme gedeelte van een planeetvormende schijf. Het methanol kan daar niet ontstaan zijn en moet uit de koude gaswolken komen waaruit de ster en de schijf zijn gevormd. Het methanol…

Shell onderzoekt samen met theoretische natuurkundigen en chemici van de Universiteit Leiden hoe quantumcomputeralgoritmen complexe moleculen kunnen simuleren.

Jonge veelbelovende wetenschappers hebben via het World Economic Forum zelf een ‘code of ethics’ geschreven. Chemicus en medeauteur Sander van Kasteren vertelt over het belang hiervan: ‘We willen laten zien dat wetenschappers morele wezens zijn, die ook deel uitmaken van de maatschappij.’

De Leidse chemicus Mario van der Stelt ontwikkelde een sensor die kan zien hoe bepaalde eiwitten een rol spelen bij de ontwikkeling van obesitas. Ook vond zijn team een stof die deze eiwitten afremt. De ontdekking is gepubliceerd in ‘Angewandte Chemie’.