Promotie

The research described in this thesis has, using the zebrafish as a model system, shed new light on the intricate relationship between TB and DM2, in particular on the role of leptin, SHP-1 and glucocorticoids.

Artificial intelligence algorithms govern in subtle, yet fundamental ways, the way we live and are transforming our societies. The promise of efficient, low‐cost or ‘neutral’ solutions harnessing the potential of big data has led public bodies to adopt algorithmic systems in the provision of public…

NWO heeft elf Leidse wetenschappers een Vidi-beurs toegekend.

Als artsen beter kunnen inschatten wat de overlevingskansen van een patiënt zijn, helpt dat om te kiezen voor een bepaalde behandeling. Bij het zeldzame en kwaadaardige Ewing-sarcoom dat vooral kinderen en adolescenten treft, zou dat enorm helpen. Wiskundehoogleraar Marta Fiocco mag met een grote KWF-subsidie…

Intelligente apparaten zullen over 20 jaar een grote rol spelen in de maatschappij. ‘Zelfrijdende auto’s zullen 90% veiliger zijn dan auto’s met menselijke chauffeurs en de transportsector wereldwijd veranderen.’ Dat zei kunstmatige-intelligentie-onderzoeker Bart Selman van Cornell University in de…

Hoe kunnen praktijk en theorie elkaar versterken in de neurowetenschappen? Hoogleraar Birte Forstmann spreekt in haar oratie op 2 oktober over het bouwen van interdisciplinaire bruggen tussen cognitieve neurowetenschap en cognitieve modellen. Haar aanpak kan bijdragen aan hersenonderzoek met minder…

This thesis deals with the use of sound in interactions in the context of participatory systems and data sonification. We investigate an interactive environment where participants perceive information of the data through sound elements.

In this thesis, I study 1) metabolic alterations in tuberculosis related to wasting syndrome in human patients as well as in rodent and fish animal models. 2) effects of the mutation of the leptin gene on cachexia and diabetes in rodent and zebrafish animal models.

With the emergence of online social networks (OSNs), the way people create and share information has changed, which becomes faster and broader than traditional social media.

Promotor: Prof.dr. M. Danhof

Promotor: A.W. van der Vaart

This thesis explores Breaking of Ensemble Equivalence (BEE) in random graph models by examining the spectral properties of adjacency matrices. The goal is to identify spectral characteristics that differentiate random graph ensembles, enhancing the understanding of complex network structures and beh…

Promotor: J. Schaye

In this work, we attempt to answer the question:

Galaxies form and live inside dark matter haloes. As a consequence, they are exposed to the tidal fields generated by the surrounding matter distribution: this imprints a preferential direction to the galaxy shapes, which leads to a coherent alignment on physically close galaxies, called intrinsic a…

Image segmentation is a fundamental task in computer vision, with applications ranging from medical diagnostics to archaeological research.

Promotor: Prof.dr. K.J. Batenburg

This thesis explores the theoretical and observational properties of distant massive galaxies that harbour active black holes in their centres and shine brightly at radio wavelengths.

A dense region of a gaseous and dusty cloud collapses to form a protostar surrounded by a disk and an envelope. This thesis uses both observations and models to study physical and chemical conditions of these protostellar systems which are likely where planets start to form.

Over the last three decades, the discovery of exoplanets has revealed the boundless variety of worlds beyond our own Solar System⁠. Majority of planetary systems contain short-period planets that are larger than Earth but smaller than Neptune⁠.

The energy system is at the heart of two of the greatest challenges of the 21st century: decreasing CO2 emissions to meet the ambitions of the Paris agreement while fulfilling the growing energy demand associated with the economic aspirations of a growing world population.

The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.

Promotores: Prof.dr. H.P. Spaink & Prof.dr. P.C.W. Hogendoorn Co-promotor: Dr. M.J.M. Schaaf

Ice, the solid state of water, plays an important role on our planet as well as the entire universe.Despite the fact that an individual water molecule has a very simple structure, its chemical bonding in the solid phase can be surprisingly complex.

Nucleoid associated proteins maintain the architecture of the bacterial chromosome and regulate gene expression, hinting that their role as transcription factors may involve local three-dimensional chromosome re-modelling.

Growth and development affect the metabolism of drugs administered to neonates, infants, and children.

We consider the propagation of electrical signals through nerve fibres.

Naar motivatie wordt al 100 jaar onderzoek verricht. En dat is niet verwonderlijk, want motivatie ligt aan de basis van ons bestaan. Waarom doen we de dingen die we doen? Waarom willen we iets, of stellen we juist uit? Maar ook in grote dingen: waarom worden we verliefd, kopen we een huis, starten we…

Drug development critically depends on preclinical models that mimic human physiology, yet traditional two-dimensional cultures and animal models often lack predictive power.

This thesis explores Breaking of Ensemble Equivalence (BEE) in random graph models by examining the spectral properties of adjacency matrices. The goal is to identify spectral characteristics that differentiate random graph ensembles, enhancing the understanding of complex network structures and beh…

De jury van de J. Kok Juryprijs heeft het proefschrift van Stéphanie van der Pas geselecteerd als beste proefschrift van 2017 van de Faculteit der Wiskunde en Natuurwetenschappen. Rector magnificus Carel Stolker overhandigde haar de onderscheiding tijdens de facultaire nieuwjaarsreceptie op 9 januar…

Hoe bepaal je bij een kind de juiste dosering van een medicijn? Dat kan niet altijd op basis van lichaamsgewicht. Maar soms kan dat wèl, ontdekte farmacoloog Elke Krekels. Ze won hiermee de TOP-Publicatieprijs van de Nederlandse Vereniging voor Klinische Farmacologie en Biofarmacie. In de uitzending…

This study has been carried out in the community of Sukamiskin, a kelurahan (‘village’) in Bandung, the Capital of West Java Province, located in the Sunda Region of Indonesia.

Tijdens de nieuwjaarsreceptie van de Faculteit der Wiskunde en Natuurwetenschappen op 7 januari jongstleden is bekend gemaakt dat Wouter Duivesteijn het beste proefschrift van 2013 heeft geschreven.

How do opinions form and change in large groups of people? That's not just a sociological question, it's a mathematical one. PhD candidate Federico Capannoli studied opinion dynamics. He defended his thesis on November 19.

Promotor: Prof.dr. S.F. Portegies Zwart

Promotores: Prof.dr. C.U. Keller, Prof.dr. H.C. Gerritsen

Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver

This thesis investigates the relations between metabolism and anatomy through the use of Magnetic Resonance Imaging (MRI).

The main focus of this thesis is the behaviour of two-dimensional materials, namely (anti)-ferromagnetic materials in the first two chapters, which show topological phases, and energetic square ice in the third and fourth chapter.

In this thesis, I investigated the neurogenetic properties of Neotropical bat species. Bats represent the second largest mammalian order (Chiroptera) in the world, with Neotropical bats constituting about 13% of the total number of bat species.

The main theme of this thesis is the theoretical study of Gaussian processes as a tool in Bayesian nonparametric statistics.

Ze ontwikkelt algoritmes die toonaangevende optimalisatietechnieken overtreffen en breed toepasbaar zijn. Het team van Niki van Stein krijgt hiervoor de GECCO Humies Award. ‘Met onze methode kunnen we voor diverse apps algoritmes maken en doorontwikkelen die beter zijn dan de huidige.’

Om te worden toegelaten tot Forensische Criminologie aan de Universiteit Leiden, moet je aan de onderstaande toelatingseisen voldoen.

Het project programmanormen bevat richtlijnen voor de inrichting van het onderwijs van de Faculteit der Geesteswetenschappen