Als gevolg van de grote technologische vooruitgang in de gezondheidszorg worden in toenemende mate gegevens verzameld tijdens de uitvoering van klinische onderzoeken.

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof.dr. A.H. Meijer

Microglia support the central and peripheral nervous system by forming the first line of defense against hazardous events. Microglia are increasingly acknowledged as critical players in neurodegenerative diseases, highlighting them as potential therapeutic targets.

The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

Promotor: A.P. IJzerman

The research provides insight into disease behavior in both rural and semi-urban areas in Serengeti in Tanzania.

Over several decades, a variety of computational methods for drug discovery have been proposed and applied in practice. With the accumulation of data and the development of machine learning methods, computational drug design methods have gradually shifted to a new paradigm, i.e. deep learning methods…

Promotor: A.P. IJzerman Co-promotor: L.H. Heitman

Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: L.H. Heitman

This thesis describes the structural and biochemical characterization of the β-lactamase BlaC from Mycobacterium tuberculosis (Mtb), and the Alr and YlmE proteins from Streptomyces coelicolor A3(2).Mtb is the main cause of tuberculosis.

The present thesis focuses on the pharmacological concept of drug-target interaction, which dates back to the beginning of modern pharmacology.

Promotor: S.M. Verduyn Lunel, Co-Promotores: S.C.Hille, O.W. van Gaans

Promotor: Prof.dr. J.W.M. Frenken

Promotores: A.P. IJzerman, H.W.T. van Vlijmen

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

Promotor: Prof.dr. E. Bouwman, Co-promotor: S. Bonnet

The cellular metabolism of immune cells constitutes an important part of their proper function and activation. Using T cells as an example, this phenomenon is highlighted by the metabolic reprogramming that occurs in these cells upon activation.

Promotor: H.J.A. Röttgering, Co-promotor: G.K. Miley

Over the past years it has been discovered that the population of extra-solar planets is large and diverse.

The intracluster medium (ICM) is a hot, tenuous and X-ray emitting gas that pervades galaxy clusters.

The origin and evolution of galaxies are closely linked to many different physical phenomena.

In this thesis chemical and physical processes in the ice mantles on interstellar dust grains are studied.

Promotor: Prof.dr. H.V.J. Linnartz, Co-Promotores: S. Ioppolo, H.M. Cuppen

Protoplanetary disks are the gas and dust environments where planetary systems form around young stars. Using observations from the Atacama Large Millimeter/submillimeter Array (ALMA) this thesis analyses the gaseous molecular reservoir, using multiple tracers to resolve the 3D structure of protoplanetary…

The largest structures in the Universe are clusters of galaxies. Each can contain hundreds to thousands of galaxies.

In this thesis, I studied the origin and evolution of the non-thermal radiation in merging galaxy clusters.

Promotor: Prof. dr. A.G.G.M. Tielens

Promotor: Prof.dr. S.F. Portegies Zwart

This thesis is largely an experimental study on the formation of solid-state simple and complex organic molecules in the H2O-rich and CO-rich ice phases of dense interstellar clouds and dark cores.

Galaxies form and evolve through close interaction with their surroundings. As a result, the heavy elements ('metals') that are synthesized in stars, are found both inside and outside galaxies.

Promotor: Prof.dr. M. Franx, Co-Promotor: Rychard Bouwens

Promotor: Prof.dr. A.G.G.M. Tielens, Prof.dr. C. Dominik (UvA)

Promotor: Prof.dr. H.V.J. Linnartz

Promotores: Prof.dr. C.U. Keller, Prof.dr. H.C. Gerritsen

In this thesis new methodologies are developed for the detection and systematic study of radio sources in the early universe. This allows us to gain a deeper understanding of the formation and evolution of galaxies, the activity of supermassive black holes, and the final phase transition of our universe:…

Promotor: K.H. Kuijken

This thesis develops a method for direction dependent calibration of the ionosphere in radio interferometric data.

Over geschiedenis van de sterrenkunde van radioastronomie tot exoplaneten, de revolutionaire ontwikkeling van de naoorlogse sterrenkunde.

Radio jets are important to the evoultion of galaxies. However, it is still not fully understood how a radio jet can be triggered.

Wat is er nodig om een mens te maken? Een uitdijend heelal. Gebouwd uit deeltjes, ruimte en tijd, en hun subtiele mechanismen.

Forming at the nodes of the Cosmic Web and growing hierarchically via mass accretion, galaxy clusters are the largest virialized halos in our universe, composed of dark matter (DM; ≥85%), ionized hot plasma in the intracluster medium (ICM; ≥10-15%), and galaxies (≥1-5%).

The Sun and all the stars in the night sky reside in the Milky Way galaxy. In the at-rest reference frame of the Galaxy, typical stars travel with velocities of about 100-200 kilometres per second.

In the past decade many population studies have been performed with the Atacama Large Millimeter/submillimeter Array (ALMA) to understand the bulk properties of protoplanetary disks around young stars. These population studies mostly consisted of low mass stars, with relatively few of the disks around…

Promotores: Prof.dr. M. Franx, Prof.dr. M. Kriek (Univ. of California at Berkeley)

Promotores: Prof.dr. M. Franx, Prof.dr. P.G. van Dokkum (Yale University)

This thesis contributes to studying primordial cosmology theories and their detectability in future observations.

Promotor: Prof.dr. H.L.V. Linnartz