In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.

In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…

Breast cancer is the most common cancer in women worldwide. Metastasis, the process by which cancer cells spread to other parts of the body, makes treatments less effective. It is important to unravel the mechanism of metastasis.

The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.

To improve cancer treatments, personalized medicine approaches have aimed to identify exactly which mutations are driving tumor development in a given patient and specifically target these mutations using precision therapies.

The spindle-assembly checkpoint (SAC) is a safety mechanism which secures accurate chromosome segregation during mitosis.

Promotor: R.C.M. Pelger Co-Promotor: G. van der Pluijm

Promotor: B. van de Water, Co-promotor: E.H.J. Danen

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The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…

To improve treatment of breast cancer patients it is important to understand all stages of breast cancer from initiation to in situ disease and progression to invasive disease. In this thesis we use intraductal injections of patient derived tissue to model ductal carcinoma in situ and invasive breast…

In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).

Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.

Promotores: J. Jonkers, K.E. de Visser

Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.

The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

G protein-coupled receptors (GPCRs), one of the largest families of membrane proteins, are responsive to a diverse set of physiological endogenous ligands including hormones and neurotransmitters.

The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.

Promotores: Wim Jiskoot; Ferry Ossendorp

In this thesis, we aim to shed light on the diverse and often opposing roles of integrin α3β1 in cancer.

Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.

Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.

Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

Promotor: Prof.dr. H.P. Spaink, Co-promotor: Dr. B.E. Snaar

This interdisciplinary minor addresses sustainabilty challenges from a systems perspective, and investigates ways to sustain society within planetary boundaries.

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Promotor: E. Bouwman, Co-promotor: S. Bonnet

The human body consists of hundreds, perhaps thousands of different types of cells, each with different morphologies and functions, despite having the same genome.

Promotores: W. Jiskoot, F. Ossendorp

Promotor: H.S. Overkleeft, J. Neefjes, Co-promotor: M. van der Stelt

The goal of the research presented in this thesis was to explore the chemical space of ruthenium(II) photocages, investigate their ability to host potent chemotherapy drugs, and to red shift the activation wavelength of the most promising PACT candidates to conduct biological studies.

Prostate cancer (PCa) is one of the most prevalent cancer in males.

This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.

The development process of any software has become extremely important not just in the IT industry, but in almost every business or domain of research.

Let op: bachelorstudenten van de Faculteit der Rechtsgeleerdheid kunnen vakken uit het eigen curriculum niet opvoeren voor deze minor. Je kunt alleen de gebonden keuzevakken volgen en opvoeren die geen onderdeel uitmaken van je eigen bachelorprogramma.

Wil je weten welke invloed opvoeding binnen en buiten het gezin heeft op de ontwikkeling van het kind? Kies dan deze specialisatie!

In onze eenjarige masteropleiding leer je hoe je het dagelijks leven van kwetsbare groepen - zowel in Nederland als wereldwijd - kunt bestuderen, en hoe je ze binnen de complexe processen van sociale en globale ontwikkeling kunt plaatsen.

Voor wie geïnteresseerd is in de relatie tussen neuro-cognitieve en biologische factoren enerzijds en leren, gedrag en emoties anderzijds.

Promotie

Promotie

Het volgende rapport bespreekt onze enquête over de UN Sustainable Development Goals die werd verspreid onder onderzoekers aan de Universiteit Leiden in november 2021.

Kom naar onze online en oncampus events om ons beter te leren kennen!

The Advanced Master's specialization Peace, Justice and Development at Leiden University examines the legislation that governs international relations in an increasingly complex, interdependent global society. The study covers a wide range of legal disciplines like criminal law, human rights law, investment…

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Lees meer over de informatieve activiteiten voor de MSc Nationalism, Ethnic Conflict and Development aan Universiteit Leiden – zoals webinars, online open dagen, virtuele rondleidingen en Master Talks-video’s.

Ontwikkel je onderwijsvaardigheden samen met docenten van andere Nederlandse universiteiten.

Bekijk het studieprogramma van de MSc Nationalism, Ethnic Conflict and Development aan Universiteit Leiden: semesterindeling, studiepunten, kern- en keuzevakken.

Neem contact op voor vragen over de MSc Nationalism, Ethnic Conflict and Development aan Universiteit Leiden, zoals over de opleiding zelf of ondersteuning via het Admissions Office.