LUMC Technology Focus Area (TFA) Data Analytics is een samenwerkingsverband van verschillende onderzoeksgroepen in het LUMC die nieuwe kwantitatieve en computationele methodologie ontwikkelen voor biomedisch en klinisch onderzoek.

The deeper understanding of an organism's pathology is important for developing treatments. Over centuries of systematic research, clinical researchers have demonstrated that the more information they acquire about the cellular properties and their organisation in the tissue, the better they can understand…

Despite being the object of intense study, embryonic development has been difficult to model due to a number of reasons. First, complex tissues can be comprised of many cell types, of which we probably only know a subset.

This dissertation focused on computational methods based on first principles calculations using the Density Functional Theory (DFT) framework. Emphasis was laid on affordable methods that can provide a tradeoff between computational expense and accuracy.

Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)

Hoogleraar Fons Verbeek, verbonden aan de informatica- en biologie-instituten van de Universiteit Leiden, heeft de fascinatie om alles wat we niet direct kunnen zien, toch in beeld te brengen. Op SleutelstadFM vertelt hij dat door het omrekenen van 2 dimensionale (2D) beelden naar 3 dimensionale (3D)…

Promotor: Roeland M.H. Merks

Nature uses a special class of histone proteins, histone variants, to modulate the properties of chromatin at defined genomic locations.

Epithelial-mesenchymal plasticity (EMP) and tumor cell migration play an important role in cancer progression, and an improved understanding of the mechanisms underlying these concepts is essential for developing new targeted approaches.

Wiskunde en Natuurwetenschappen, Leiden Institute of Advanced Computer Science (LIACS)

This thesis introduces the concept of

Carbohydrates, or sugars, are the most diverse and most abundant biomolecules known. However, the isolation of carbohydrate samples in sufficient amounts and purity is often impractical or even impossible, so the chemical synthesis of glycosides becomes relevant. The glycosylation reaction, in which…

Archeologie

De master Biology is een samenwerking tussen het Instituut Biologie Leiden, Naturalis en het Centrum voor Milieuwetenschappen Leiden waardoor het programma een brede en diverse scope heeft. De opleiding biedt zeven specialisaties, waarvan vier researchspecialisaties die nauw verbonden zijn met het onderzoek…

There is a need for alternative methods to replace, reduce and refine (3R) animal experimentation. Combining experimental data from high-throughput in vitro studies with in silico modeling is a promising approach to unravel the effect of chemicals on living cells and to gain a better understanding of…

Quantitative biology means exploiting mathematical modelling and computer simulation as a tool to gain additional insights into the meaning of experimental data. Discover in this minor when and how to apply these tools, in a multidisciplinary setting.

In the current global context, there is a pressing need to address sustainable energy supplies to safeguard our Planet and its ecosystems. The choices made by human society have a significant impact on genetic evolution and climate.

The Minor Computational Approaches to Disease, Signaling and Drug Targets (CADSDT) is focused on fundamental scientific research required for discovery of new drug targets and development of new drugs.

Het chemische biologie-onderzoek bij het Leids Instituut voor Chemisch Onderzoek (LIC) is gericht op het begrijpen van biologische processen op moleculair niveau, om zo onze kennis te vergroten over gezondheid en ziekte van de mens.

De afdeling richt zich op het verbeteren van het wetenschappelijk begrip in de relatie tussen mens en natuur. Hoe beïnvloedt menselijk handelen (via bijvoorbeeld klimaatverandering, landgebruiksverandering en de emissie van mogelijk toxische verbindingen) de natuur in het algemeen en de biodiversiteit…

This thesis investigates the contribution of quantum computers to machine learning, a field called Quantum Machine Learning. Quantum Machine Learning promises innovative perspectives and methods for solving complex problems in machine learning, leveraging the unique capabilities of quantum computers…

Na afronding van deze opleiding beschik je over een eerstegraads onderwijsbevoegdheid en ben je goed voorbereid op een carrière als docent Biologie in het voortgezet onderwijs.

In deze opleiding identificeer je evolutionaire veranderingen over de tijd en bestudeer je de oorsprong en het behoud van biologische variatie in de Tree of Life.

Promotor: Prof.dr. J.N. Kok

Optical projection tomography (OPT) is a tomographic 3D imaging technique used for specimens in the millimetre scale.

Van systeembiologische modellering een centrale pijler van het onderzoek in de biologie maken.

Cancer is considered the silent pandemic of the 21st century and the second leading cause of death worldwide.

Deze opleiding biedt de mogelijkheid om biologie-onderzoek te combineren met kennis over ondernemerschap en ervaring in het bedrijfsleven.

In this work we describe three methods to improve the performance of Quantum Field Theory calculations.

The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…

In deze opleiding ligt de focus op het informeren van het algemene publiek over belangrijke wetenschappelijke onderwerpen en hoe je deze communicatie wetenschappelijk onderbouwt.

Assessing the risks of engineered nanomaterials (ENMs) solely on the basis of experimental assays is time-consuming, resource intensive, and constrained by ethical considerations (such as the principles of the 3Rs of animal testing). The adoption of computational toxicology in this field is a high p…

Most of current public-key cryptography is considered insecure against attacks from sufficiently powerful quantum computers. Post-quantum cryptography studies methods to secure information resistant against such attacks. One proposal is isogeny-based cryptography, which bases its security on computational…

Deze opleiding biedt de mogelijkheid om onderzoek op moleculair, cellulair en organismaal niveau te verenigen, maar biedt ook de mogelijkheid om je te specialiseren op één van deze niveaus.

Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…

The zebrafish is a promising vertebrate model organism in early drug discovery and development.

Balsaminaceae is a diverse plant family characterized by a huge floral morphological diversity.

Wiskunde en Natuurwetenschappen, Leiden Academic Centre for Drug Research (LACDR)

In this thesis, we consider various (electro)chemical phenomena at surfaces and nanoparticles and their underlying atomistic processes, which we studied using first-principles methods such as density functional theory.

De afdeling Environmental Biology (CML-EB) houdt zich bezig met vraagstukken rondom biodiversiteit en natuurlijke hulpbronnen op het platteland in westerse en niet-westerse gebieden.

The research described in this thesis centered on retaining exo-β-glucosidases implicated in health and disease, in particular the human inherited lysosomal storage disorder, Gaucher disease (GD).

We developed the bitterling as a unique, well-studied model organism in the area of the evolutionary ecology of brood parasitism. The bitterling-mussel relationship, interspecific mussel host preference, and mussel gill structure are studied in detail, to help understand the developmental adaptation…

In this thesis it is posed that the central object of preference discovery is a co-creative process in which the Other can be represented by a machine. It explores efficient methods to enhance introverted intuition using extraverted intuition's communication lines.

This thesis systematically studies the physicochemical properties of non-planar, propeller-shaped, polycyclic aromatic hydrocarbons. The synthesis of several so-called propellerenes is described on a gram scale, using optimized procedures aimed at using less hazardous reagents and reducing the amount…

Wiskunde en Natuurwetenschappen

During embryonic growth, cells proliferate, differentiate, and collectively migrate to form different tissues at the right position and time in the body.

In this thesis, we describe the potential of cell mechanical phenotyping for immune cell characterization, diagnosis, drug testing, as well as treatment of disease.

Het FAIRDOM-consortium is een open initiatief van verschillende partners, waaronder financieringsprogramma's, grote consortia, instituten, kleine groepen en individuen.