The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.

In this thesis, we aimed to better understand the underlying mechanisms involved in TNBC progression and metastasis formation and discover new targets to reduce breast cancer related deaths.

Promotor: R.C.M. Pelger Co-Promotor: G. van der Pluijm

Promotor: B. van de Water, Co-promotor: E.H.J. Danen

The spindle-assembly checkpoint (SAC) is a safety mechanism which secures accurate chromosome segregation during mitosis.

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Breast cancer is the most common cancer in women worldwide. Metastasis, the process by which cancer cells spread to other parts of the body, makes treatments less effective. It is important to unravel the mechanism of metastasis.

The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…

To improve treatment of breast cancer patients it is important to understand all stages of breast cancer from initiation to in situ disease and progression to invasive disease. In this thesis we use intraductal injections of patient derived tissue to model ductal carcinoma in situ and invasive breast…

Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.

Promotores: J. Jonkers, K.E. de Visser

The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

To improve cancer treatments, personalized medicine approaches have aimed to identify exactly which mutations are driving tumor development in a given patient and specifically target these mutations using precision therapies.

The main aim of this thesis was to unravel the signaling and regulatory networks that drive tumor cell migration during breast cancer metastasis.

Promotores: Wim Jiskoot; Ferry Ossendorp

Transnationale misdrijven zoals mensenhandel en terrorisme vereisen steeds meer gecoördineerde strafrechtelijke reacties op Europees of internationaal niveau.

In this thesis, we will utilize embryonic zebrafish tumour models to understand the interaction between engrafted human cancer cells and macrophages from the host, test drug administration modalities and anti-cancer efficacies of newly-developed PDT and PACT compounds, and test a light-triggered liposomal…

In this thesis, we aim to shed light on the diverse and often opposing roles of integrin α3β1 in cancer.

Triple-negative breast cancer (TNBC) is a subtype of breast cancer characterized by limited treatment options and unfavorable clinical outcomes. Therefore, the research described in this thesis focused on the exploration of novel targeted therapies for TNBC.

Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.

Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska

The research described in this thesis focused on identifying novel drug targets and synergistic combinations for triple-negative breast cancer (TNBC), a virulent subtype of breast cancer with a dismal prognosis and limited therapeutic options.

Op 23 februari 2022 verdedigde Cale Davis het proefschrift 'Prosecutorial Discretion in International Criminal Justice'. Het promotieonderzoek is begeleid door prof.dr. C. Stahn en dr. J.C. Powderly.

Op 12 mei 2020 verdedigde Darryl Robinson zijn proefschrift 'Exploring Justice in Extreme Cases: Criminal Law Theory and International Criminal Law'. Het promotieonderzoek is begeleid door promotor prof.dr. C. Stahn.

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

Promotor: E. Bouwman, Co-promotor: S. Bonnet

The Advanced Master's specialization International Criminal Law at Leiden University examines international criminal law and international criminal procedure. Students will study the systemic environment of international criminal law and its link to related fields, such as international human rights…

G protein-coupled receptors (GPCRs), one of the largest families of membrane proteins, are responsive to a diverse set of physiological endogenous ligands including hormones and neurotransmitters.

Promotores: W. Jiskoot, F. Ossendorp

Hoe moet de internationale gemeenschap reageren als er sprake is van genocide, oorlogsmisdrijven of misdrijven tegen de menselijkheid? Hoe kan zij de daders berechten, herhaling voorkomen en internationale eensgezindheid bevorderen en daarbij afstanden en cultuurverschillen overbruggen? De juristen…

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In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).

Traditional drug discovery approaches have been hampered by (in vitro) cell-culture models that poorly represent the situation in the human body.

Het Instituut voor Strafrecht & Criminologie is betrokken bij internationale samenwerking en uitwisseling.

Prostate cancer (PCa) is one of the most prevalent cancer in males.

This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.

Het strafrecht kent complexe morele vraagstukken over de rechtvaardiging van het strafsysteem, het type en mate van de toepassing van strafrechtelijke sancties, de inhoud van de strafmaatregelen (gevangenisstraf, boetes, alternatieve straffen), de aard van de persoon met strafrechtelijke autoriteit,…

What Determines Perceptions of Bias toward the International Criminal Court? Evidence from Kenya. In dit artikel, gepubliceerd in op de website SAGE Journals in het Journal of Conflict Resolution, onderzoeken de auteurs Geoff Dancy, Yvonne Marie Dutton, Tessa Alleblas, Eamon Aloyo de houding ten opzichte…

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In dit artikel onderzoeken de auteurs hoe het internationaal strafrecht overgaat naar een ‘post-kritische’ fase en bekijken ze het potentieel voor emancipatoire hervorming.

Op 18 september 2019 verdedigde Huw Llewellyn zijn proefschrift 'An Institutional Perspective on the United Nations Criminal Tribunals: Governance, Independence and Impartiality'. Het promotieonderzoek is begeleid door promotoren prof.dr. N.M. Blokker en prof.dr. L.J. van den Herik.

Het Antoni van Leeuwenhoek/Nederlands Kanker Instituut, het Leids Instituut voor de Chemie en het Pivot Park Screening Centre gaan kennis en infrastructuur delen in het Cancer Drug Discovery Initiative. Vrijdag 11 oktober tekenden ze een letter of intent.

Op 19 juni 2018 verdedigde Matthew Gillett zijn proefschrift ‘Prosecuting environmental harm before the international criminal court’. De promotoren is prof.dr. L.J. van den Herik.

Criminal Justice Onderzoeksprogramma van het Instituut voor Strafrecht en Criminologie

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Death in all types of melanomas is generally caused by metastasis. Uveal melanoma (UM) is the most common intraocular melanoma, there are currently no (patient-derived) animal models that faithfully recapitulate metastatic dissemination of UM.