De EEE-lezingen zijn een maandelijkse interdisciplinaire lezingenreeks waar wereldwijd gerenommeerde en inspirerende denkers en wetenschappers worden uitgenodigd.

De prof. A.E.J. Modderman Stichting is verbonden aan de Universiteit Leiden en beoogt bevordering van het onderzoek op het gebied van de strafrechtswetenschappen.

This book aims to be a point of reflection and debate for journalists, academics and students to recognize a fundamental task in the duty of the communications professional, which is to influence through their daily work and their routines in order to achieve a more inclusive and plural society, through…

Nederlandse politicologen laten hun licht schijnen over het veranderende electoraat.

Promotores: Prof.dr. J.N. Kok, Prof.dr. C.A. Mandemakers, Co-Promotor: G. Bloothooft

In this thesis an activity-based probe was discovered that could visualize the activity of PLAATs. With an optimized gel-based ABPP assay in hand, screening of a compound library led to the discovery of alpha-ketoamides as a hit for PLAAT3.

Op 25 september promoveert Alzenir Mendes Martins de Menezes. Het Leiden University Centre for Linguistics feliciteert Alzenir!

Pulsars were first discovered in 1967 and since then the population has grown and expanded over several wavelengths.

Promotor: Prof.dr.ir. J.G.E.M. Fraaije, Co-promotor: A. Kros

Patients share valuable advice and experiences with their peers in online patient discussion groups.

β-Lactamases are enzymes that can break down β-lactam substrates, such as antibiotics, preventing the use of these antibiotics for the treatment of various infectious diseases. However, some compounds, β-lactamase inhibitors, can block these enzymes allowing for possible treatments using a combination…

Deze zomer verruilen de jonge Leidse politicologen Feike Fliervoet en Gerrit Krol hun vertrouwde bestaan als werkgroepdocent voor een onderzoeksplek in Florence. Na vele jaren te hebben gewerkt als student en vervolgens docent bij Politieke Wetenschap, worden zij promovendus aan het gerenommeerde European…

Over de sporen die Darwin, hoewel nooit in Leiden geweest, er toch achterliet.

The main goal of the research described in this thesis was the development of new photoactivated chemotherapy (PACT) ruthenium(II) complexes bearing a non-toxic photolabile ligand.

Promotores: R. Cramer, A.K. Lenstra, Co-Promotor: B.M.M. de Weger

Promotores: Prof.dr. G.F.A. Kersten, W. Jiskoot, Co-promotor: J-P. Amorij

The external tissues of plants and animals are colonized by microbial communities termed microbiota. When organisms are exposed to environmental pollutants, these substances will therefore encounter microbiota at the exposure interface.

At the moment, over 350.000 chemicals are registered worldwide for production and use. Their application, however, may harm human health and the environment.

Promotor: J. van der Greef, T. Hankemeier; Co-promotor: H.A. van Wietmarschen

Tijdens de viering van de 54ste Dies Natalis van Universitas Padjadjaran in Bandung, Indonesië, zijn op 9 september 2011 onderscheidingen uitgereikt aan de Leidse prof.dr. L.J. Slikkerveer en drs. L.E.H. Vredevoogd. Zij kregen deze voor hun uitzonderlijke bijdrage aan de succesvolle wetenschappelijke…

This thesis aimed to investigate the impact of exposure dynamics, relative contributions of ENPs(particle) and ENPs(ion), and dosing regimens on the toxicity of ENPs varying in different physico-chemical properties, on the composition and functioning of soil microbial communities.

Nanodiscs are small, disc-shaped structures designed to mimic biological cell membranes, composed of a lipid bilayer stabilized by scaffold proteins. Membrane proteins play crucial roles in essential processes such as nutrient and waste transport, molecular recognition, and cell signalling, making them…

Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.

The research in this dissertation aims to optimise blood donation processes in the framework of the Dutch national blood bank Sanquin. The primary health risk for blood donors is iron deficiency, which is evaluated based on donors' hemoglobin and ferritin levels.

In summary, the collective results described in this thesis show that nanoparticulate vaccines can be delivered intradermally by coated and hollow microneedles and evoke antigen-specific immune responses.

Promotor: J. Kuiper

Dissolution processes – next to aggregation processes - play an important role for fate prediction and environmental risk assessment of metal-based nanoparticles (MNPs). It is challenging to predict the kinetics of the dissolution process of MNPs in complex systems such as we can find in in vivo and…

A sustainable resource management is an essential aspect to satisfy the current human needs without compromising the needs of future generations.

The following report discusses a survey on the topic of the Sustainable Development Goals that was distributed among researchers at Leiden University in the month of November 2021.

Microscopic insight on lipid-based nanomedicine in vivo remains limited to the perception of the knowledge that could be obtained: if we interpret only what we see, then we only believe to know. Although believing to know encapsulates an undefined amount of uncertainty in the exploration of lipid-based…

Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.

New drugs for use as tuberculosis (TB) treatment are needed due to the constrains of classical antibiotics against TB and the rise of antibiotic-resistant strains, making TB a harder and harder disease to treat.

Promotores: T.H. Oosterkamp, N. de Jonge

Wat is het persoonlijke verhaal van wetenschappers als Einstein, Kamerlingh Onnes en Swammerdam? Een aantal Leidse honoursstudenten heeft een virtuele tentoonstelling opgezet om de mensen achter de ontdekkingen weer te geven.

Fate and toxicity of copper nanoparticles was related to the water chemistry of the environment and pristine size.

This thesis is an experimental study of the UV irradiation of the interstellar ice analogues, relevant for the different stages of the star and planet formation sequence.

The thesis deals with the study of giant radio galaxies (GRGs), which are radio galaxies of megaparsec sizes.

Promotor: T. Hankemeier, Co-promotor: R.J. Vreeken

Neuraminidases are enzymes that cleave glycosidic linkages of sialic acid. These enzymes are involved in influenza infections as well as in many cellular processes in mammals and micro-organisms.

Studievoorlichting

Light-Harvesting Complex II (LHCII) is responsible for light absorption and excitation energy transfer in plants and photosynthetic algae, while in high light it undergoes conformational changes by which it quenches excitations to prevent photodamage.

Accurate prediction of the unbound drug concentration-time profile at the CNS target site is crucial for the assessment of the right drug concentration-effect relationship. PBPK models have supported the PK prediction of the CNS target sites and the translation of PK data between species and between…

Promotor: Prof.dr. H.J.M. de Groot, Co-promotor: Francesco Buda

Heterogeneous catalyzed processes are highly significant to the chemical industry. Dissociative chemisorption (DC) of molecules on surfaces is always considered as a step with a high degree of rate control for heterogeneous catalysis.

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

N-acylethanolamines (NAEs), including N-arachidonoylethanolamine (anandamide, AEA), N-palmitoylethanolamine (PEA) and N-oleoylethanolamine (OEA), are signaling lipids that play an important role in different physiological process.

The aim of this thesis was to study phage infection in Streptomyces, focused on cell wall-deficient cells. Bacteriophages (or phages in short) attach to the cell wall of bacteria after which they replicate and lyse the host cell.