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Afgelopen maandag was het Equal Pay Day: op deze dag staan we er bij stil dat vrouwen vaak minder verdienen voor hetzelfde werk. Maar hoe moet dit probleem worden aangepakt? Suze Zijlstra, universitair docent, publiceerde met Anna-Luna Post een artikel in Science Guide met de vraag waarom het altijd…

Promotores: B. van de Water; P. Hogendoorn; J. Bovée Co-Promotor: E.H.J. Danen

Childhood obesity is an increasing health issue. In the first part of this thesis comorbidities in children with obesity were studied, concerning the diagnostic process and dosing regimens.

Promotors: C.A.J. Knibbe, Anthonius de Boer, Co-promotor: M.M.J. van der Vorst

Sepsis is a life-threatening condition caused by a dysregulated host response to infection, it is associated with significant morbidity, mortality, and with a high financial burden on global healthcare systems. Bacterial infections are the primary cause of sepsis, but the growing prevalence of antimicrobial…

Fungal infections pose a significant threat to individuals with compromised immune systems and despite advancements in diagnosis and treatment, they continue to jeopardize patient’s health.

The aim of this thesis was to develop novel treatment strategies for different types of eye melanoma utilizing zebrafish models. We first establish orthotopic and ectopic xenograft models for uveal and conjunctival melanoma by engraftment of the immortalized cells derived from these tumors into zebrafish…

Cardiovascular diseases are the primary cause of death in the world with atherosclerosis as primary underlying cause.

The spindle-assembly checkpoint (SAC) is a safety mechanism which secures accurate chromosome segregation during mitosis.

This thesis represents a comprehensive investigation into the control of cancer stemness and metastatic initiation using a combination of advanced zebrafish xenograft models and in vitro assays.

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This thesis focuses on using liposomes in two different treatment strategies; vaccination (or immunotherapy) and delivery of a small molecule, and in two different disease models; cancer and atherosclerosis.

The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.

Lipid signaling is an essential biological event/process in a plethora of pathophysiological conditions. The underlying idea of this thesis is that many of the roles and the complex interplay of the individual signaling lipids in inflammatory processes and related conditions in health and disease is…

Description of Development of a low cost technology for in-situ treatment of groundwater for potable and irrigation purposes (TiPOT) (2004 - 2007)

The ultimate aim of this project is to improve cooperation between courts in different Member States.

Formele gelijkheid vormt sinds lange tijd het hart van EU en internationaal non-discriminatierecht. Daarnaast is materiële gelijkheid door de jaren heen een wettelijke norm geworden, onder meer door middel van de ontwikkeling van de concepten van indirecte discriminatie en doeltreffende aanpassingen…

Jasmina Mačkić, universitair docent bij het Europa Instituut, heeft een lezing verzorgd over onderwerpen gerelateerd aan discriminatie gedurende de ‘Equal Rights Conference “Show Your True Colours”’ in Leiden. De conferentie is georganiseerd door AEGEE-Leiden en duurde van 24 tot en met 27 mei 2018.

M. Danhof, Co-promotores: J. Freijer, A. Yassen

Dr. Moritz Jesse, universitair hoofddocent bij het Europa Instituut, presenteerde zijn paper Building Bridges or Erecting Walls? – The Application of Equal Treatment and Non-Discrimination in Europe ‘ tijdens de jaarlijkse bijeenkomst van de Vereniging voor Recht en Samenleving.

Triplet superconductivity refers to a condensate of equal-spin Cooper pairs (pairs of electrons with equal spin).

The bacterial cell wall is a nearly universal structure that offers protection and gives the cell its shape. However, environmental stressors, such as cell wall-targeting antibiotics and hyperosmotic conditions, can induce bacteria to shift to a wall-deficient state. It is unknown whether the lack of…

In this thesis, we aim to shed light on the diverse and often opposing roles of integrin α3β1 in cancer.

Explaining treatment response variability between and within patients can support treatment and dosing optimization, to improve treatment of individual patients.

Promotor: S.M. Verduyn Lunel, Co-promotores: M.F.E. de Jeu, B. de Pagter

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The effective treatment of tuberculosis (TB) remains a major challenge to global health.

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In this study the flows of PVC and its additives through the Swedish Society were followed from the cradle to the grave (from production to waste treatment).

Promotor: Prof.dr. J. Kuiper

Antimicrobial drugs constitute a fundamental part of modern medicine. The global rise in antimicrobial resistance poses a major threat to global health.

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Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…

Real-life processes are characterized by dynamics involving time. Examples are walking, sleeping, disease progress in medical treatment, and events in a workflow.

The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…

Sociale Wetenschappen, Psychologie

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Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Glucocorticoids are potent anti-inflammatory drugs widely used clinically to treat various inflammatory and immune conditions. However, two main clinical problems limit their use. GCs trigger severe side effects and they induce acquired glucocorticoid resistance, especially during chronic systemic treatment…

Statistical considerations guide the design and implementation of the experiments that scientists perform. For instance, in a clinical trial about a the efficacy of a treatment, its effect in a certain minimum amount of patients has to be observed in order to make confident assertions about the efficacy…

In this PhD-thesis several new and existing data science application are described that are particularly focused on applications for tax administrations.

Kidney transplantation is a major advance of modern medicine. This course will give you state of the art updates about what used to be an experimental, risky, and very limited treatment option more than 50 years ago and is now routinely performed in many countries worldwide.

In this thesis, we describe the potential of cell mechanical phenotyping for immune cell characterization, diagnosis, drug testing, as well as treatment of disease.

Majorana fermions in superconductors are the subgap quasiparticle excitations that are their own antiparticles.

Promotor: Prof.dr. C.W.J. Beenakker

Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz