Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.

Promotor: Prof.dr. H.S. Overkleeft

Less than 1 in 10 drug candidates that enter phase 1 clinical trials actually gets approved for human use.

In the last decades, activity-based protein profiling (ABPP) has emerged as a powerful chemical tool that may aid the ever-challenging drug discovery process.

To this day, all cyclophellitol-based inhibitors and ABPs have been close analogues of their natural substrate counterparts. As a result, these probes showed high selectivity towards their target glycosidases.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Debat, Open meeting

Promotor: Prof.dr. T. Hankemeier

Ieder onderzoek binnen de Leidse Faculteit der Sociale Wetenschappen wordt ethisch getoetst door een ethische commissie.

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea

Promotores: Prof.dr. H.S. Overkleeft, Prof.dr. G.A. van der Marel

This thesis aimed to investigate the impact of exposure dynamics, relative contributions of ENPs(particle) and ENPs(ion), and dosing regimens on the toxicity of ENPs varying in different physico-chemical properties, on the composition and functioning of soil microbial communities.

Wetenschappers hebben afgesproken om vanuit 5 principes te werken in hun onderzoek:

The adenosine receptors are proteins that reside in the extracellular membranes of cells. Activation of adenosine receptors plays a role in many physiological and pathological processes, such as immune responses and cancers.

In this thesis we study bistable reaction-diffusion equations on lattice domains.

Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.

Verken ons wonderbaarlijke universum vanuit de plaatselijke kroeg!

Laatste technologische ontwikkelingen op het gebied van datamining en profilering.

Promotor: H.S. Overkleeft, Co-Promotor: B.I. Florea

Has there been continuity or change in US counterterrorism policy since 9/11? What factors led to the continuity or change, and how do we classify any such continuity or change?

Acute cardiovascular syndromes, including myocardial infarction or stroke, are the principal cause of death in the Western society. The main underlying pathology of cardiovascular diseases is atherosclerosis, which is caused by the accumulation of lipids and inflammatory cells in the vessel wall, in…

Promotor: S.M. Verduyn Lunel, Co-promotor: S.C. Hille

This dissertation consists of two parts, with the common theme

The main research question of this thesis was: Can nitrogen cycling on dairy farms on peat soil in the Dutch Green Heart area be improved by adapting management to the nitrogen supply from soil and by using other grassland species and crops without affecting milk production?

Glycoside hydrolases (glycosidases/GHs) are widely abundant enzymes in all kingdoms of life and are important biocatalysts that catalyze the hydrolysis of glycosidic linkages in oligo/polysaccharides, glycoproteins and glycolipids with tremendous efficiency

Promotor: C. W. J. Beenakker, Co-promotor: J. K. Asboth

Het Leiden Advocacy Project on Plastic (LAPP) is een pro bono initiatief aangaande juridische vraagstukken omtrent plastic. LAPP is opgericht om het toenemende probleem van plasticvervuiling aan te pakken en onderzoek te doen naar juridische kwesties gerelateerd hieraan. Studenten werken hierbij als…

DNA carries various forms of information. Out of these forms of information the most well-known is classical genetic information.

Like a mixture of oil and water, lipid membranes separate into two liquid phases.

The research presented in this thesis makes use of small molecules (as H2 , D2 and O2 ) on well-defined single crystal surfaces (flat Pt(111), flat Cu(211) and curved Pt(111)) to elucidate the role of surface structure and degrees of freedom in the reactant in specific surface reactions.

This thesis describes how complex and real-world relevant analytical solutions can be found starting from a simple Nagumo problem posed on one or two-dimensional lattices.

Dissociative chemisorption is an important reaction step in many catalytic reactions.

Promotor: G. J. Kroes

Congres/symposium

This thesis investigates opinion dynamics on random graphs through the lens of the voter model, a classical interacting particle system used to describe how consensus emerges in networks.

Understanding interactions in quantum many-body systems remains one of the most profound and difficult challenges in condensed matter physics.

The dissertation describes TEM experiments on heterogeneous catalysts.

The main topic of this PhD thesis is the Arakelov ray class group of a number field, an algebraic object that contains both the ideal class group structure and the unit group structure.

Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros

Promotor: M.T.M. Koper, Co-Promotor: L.B.F. Juurlink

Promotores: R. Cramer, A.K. Lenstra, Co-Promotor: B.M.M. de Weger

In de afgelopen jaren is het verzamelen en verwerken van tal van gegevens aanzienlijk toegenomen. Met behulp van nieuwe technologieën zoals data mining wordt getracht kennis te halen uit verzamelde gegevens. Vaak wordt gezocht naar profielen die eigenschappen of risico's van bepaalde groepen beschrijven.…

Promotor: Prof.dr. P. Stevenhagen, Jan-Hendrik Evertse, Co-promotor: Pascal Autissier

The research described in this thesis centered on retaining exo-β-glucosidases implicated in health and disease, in particular the human inherited lysosomal storage disorder, Gaucher disease (GD).

Promotor: A. Achúcarro, Co-Promotor: J.W. van Holten

Waarom zijn niet alle kinderen even gevoelig voor variaties in hun sociale omgeving?

My PhD research is devoted to studies of the conjectural cluster-algebraic symmetry in the theory of topological string, which is the simplest, however already non-trivial sector in the theory of string.

Polycyclic aromatic hydrocarbons (PAHs) are the most abundant class of organic compounds in space. The PAH field evolves from the constant interaction between experimentalists, theorists, modellers and observers. While laboratory research and quantum chemical calculations together set up the molecular…

Promotor: Prof.dr. C.W.J. Beenakker

Promotor: Prof.dr. M.L. van Hecke, Co-Promotor: V. Vitelli