Safety First. How local processes of securitization have affected the position and role of Dutch mayors. Nederlandse burgemeesters super-netwerkers. Nederlandse burgemeesters zien zich anno 2014 geconfronteerd met een grote variëteit aan nieuwe veiligheidsvraagstukken, waaronder radicalisering, loverboys…

In Nederland en in België nam de maatschappelijke en politieke belangstelling voor de veiligheid bij grootschalige evenementen en noodsituaties sterk toe.

Growth and development affect the metabolism of drugs administered to neonates, infants, and children.

Sobral

M. Danhof, Co-promotores: J. Freijer, A. Yassen

The Medieval Institute at Western Michigan University is delighted to host the Wallace Johnson Program for First Book Authors, a program designed to provide support and mentorship to scholars working towards the publication of their first book on the law and legal culture of the early middle ages. In…

De 3D-spectrograaf Multi Unit Spectroscopic Explorer (MUSE) is met succes geïnstalleerd en in gebruik genomen op de Very Large Telescope op Cerro Paranal, Chili. MUSE heeft tijdens zijn eerste waarnemingsperiode gekeken naar verre sterrenstelsels, heldere sterren en andere testobjecten. De Sterrewacht…

LUC is the first to confer the diploma of the Faculty of Governance and Global Affairs, the new Faculty name since January 2016 making this graduation an extra special occasion.

In Nederland en in België nam de maatschappelijke en politieke belangstelling voor de veiligheid bij grootschalige evenementen en noodsituaties sterk toe.

De expositie First Americans in Museum Volkenkunde demonstreert de veerkracht en creativiteit van inheemse Amerikanen. Indringende kunst, mode en affiches laten zien dat het verleden nooit ver weg is. Kunstenaar Jacob Meders liet zich inspireren door 16-eeuwse prenten uit de Leidse Universiteitsbibliotheek.…

Lezing

This thesis investigates how galaxies form and what diversifies the evolutionary histories of galaxies.

Promotor: Prof.dr. M. Franx, Co-Promotor: Rychard Bouwens

This thesis consists of three chapters, the first two of which concern division points of elements of the multiplicative group of a number field.

This thesis presents the first synthetic peptides ADP-ribosylated on serine, threonine, tyrosine, arginine and cysteine.

The focus of this thesis is how stars like our Sun and planets like Jupiter, Saturn, and Earth are formed.

In this thesis, two potential therapeutic targets for diabetic nephropathy were dentified and investigated. First, we show that glomerular clusterin is upregulated in diabetic nephropathy and demonstrated that recombinant clusterin protein can protect the podocytes against oxidative stress in vitro.…

The work in this thesis has been focused on two subjects. The first is the assembly of alginate oligosaccharides and the generation of building blocks for the enzymatic synthesis of alginate, and the second is the total synthesis of large fragments of the zwitterionic SP1 polysaccharide.

This thesis describes the synthesis and biochemical evaluation of a variety of cyclophellitol based activity-based probes and inhibitors targeting various endo- and exo-acting retaining glycosidases. In the last two decades a variety of probes and inhibitors for (hemi)cellulose degrading enzymes have…

Pulsars were first discovered in 1967 and since then the population has grown and expanded over several wavelengths.

Het aprilnummer van Leidschrift van 2014, 'Identiteit door strijd. Migranten en minderheden ten tijde van de Eerste Wereldoorlog' bevat bijdragen van verschillende stafleden van het Instituut voor Geschiedenis.

How do you make a technology sustainable that does not even exist yet? Well, by bringing together an interdisciplinary team of pioneering European experts right at the start and paying attention to sustainability right from the development phase.

In the first part of this thesis we study the geometry of folding patterns.

Ferritin is a spherical metalloprotein, capable of storing and releasing iron in a controllable way. It is composed of a protein shell of about 12 nm and within its cavity, iron is stored in a mineral form.

Global healthcare is on the verge of an antibiotic availability crisis as bacteria have evolved resistance to nearly all known antibacterials. Identifying new antibiotics that operate via novel modes-of-action is therefore of high priority.

This thesis is is made of three parts. The first part describes a generalization of the Chabauty's method, that can be used to determine the rational points of a curve such that s+g>r+1, where g is the genusof the curve, r is the rank of the Mordell-Weil group of the jacobian of the curve and s is…

In the first part, we introduce a new condition, called toric-additivity, on a family of abelian varieties degenerating to a semi-abelian scheme over a normal crossing divisor.

Promotores: Prof.dr. J. Aarts, Prof.dr. J.M. van Ruitenbeek

This dissertation focused on computational methods based on first principles calculations using the Density Functional Theory (DFT) framework. Emphasis was laid on affordable methods that can provide a tradeoff between computational expense and accuracy.

Cathodic corrosion is a relatively unknown phenomenon that can severely etch metallic electrodes at cathodic (negative) potentials.

Promotor: Prof.dr. C.W.J. Beenakker

Promotor: Prof.dr. J.M. van Ruitenbeek, Prof.dr. R.M. Tromp

Childhood obesity is an increasing health issue. In the first part of this thesis comorbidities in children with obesity were studied, concerning the diagnostic process and dosing regimens.

Promotor: Prof.dr. F. den Hollander, G.Maillard

Promotores: Prof.dr. E.F. van Dishoeck, Prof.dr. C.P. Dullemond

Promotor: G.P. van Wezel, Co-Promotor: E. Vijgenboom

“Temminck’s Order” is the scientific biography of Coenraad Jacob Temminck (1778–1850), a Dutch naturalist and the first director of ’s Rijks Museum van Natuurlijke Historie in Leiden.

A dense region of a gaseous and dusty cloud collapses to form a protostar surrounded by a disk and an envelope. This thesis uses both observations and models to study physical and chemical conditions of these protostellar systems which are likely where planets start to form.

Promotor: Roeland M.H. Merks

Despite being the object of intense study, embryonic development has been difficult to model due to a number of reasons. First, complex tissues can be comprised of many cell types, of which we probably only know a subset.

Promotor: Prof.dr. J. den Hertog

Promotor: R. Tijdeman, Co-promotor: H.J.J. te Riele

Promotor: J.W. van Holten

Promotores: G.R. de Snoo, W.T. de Groot, Co-promotor: C.J.M. Musters

Promotor: Prof.dr. W.T.F. den Hollander

At the largest scales, two ingredients dictate the distribution of matter in the Universe. The first is dark matter, acting as an invisible scaffolding held together by gravitational forces.

Of all the mass in our Universe, 80% is thought to consist of a hypothetical and invisible substance called dark matter (DM).